Prognosis for children with neuroblastoma presenting with paralysis

Traggis, Demetrius; Filler, Robert M.; Druckman, Hope; Jaffe, Norman; Cassady, J. Robert

doi:10.1016/0022-3468(77)90020-3

Cited by 57 publications

(45 citation statements)

References 4 publications

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“…The results of our study together with review of the literature suggest that the vast majority of patients with partial neurologic deficits will improve with either medical or surgical management [4,6,11,13,17]. For this subset of patients, it may be possible to achieve neurologic recovery, while avoiding the late orthopedic sequelae associated with laminectomy, by administering primary chemotherapy.…”

Section: Discussionmentioning

confidence: 89%

Long-term outcome of patients with intraspinal neuroblastoma

Hoover

Bowman

Crawford

et al. 1999

Med. Pediatr. Oncol.

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Section: Discussionmentioning

confidence: 89%

Long-term outcome of patients with intraspinal neuroblastoma

Hoover

Bowman

Crawford

et al. 1999

Med. Pediatr. Oncol.

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“…Further clinical as well as experimental data are available in support of chemotherapy as the primary modality for epidural decompression in highly chemosensitive tumors 37,38 ; h o w e v e r, the response of ES to initial chemotherapy is not universal (61 a 67%) 2 3 . The use of multiagent chemotherapy combined with surg e ryand/or radiotherapy for definitive local control increased diseasefree survival rates to 50 to 80% [39][40][41] .…”

Section: Fig 3 (A) Posterior Approach Intra-operative View Of Pedicmentioning

confidence: 99%

Primary Ewing’s sarcoma of the spine: case report

Dini

Mendonça

Gallo

2006

Arq. Neuro-Psiquiatr.

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-Primary malignant sarcomas of the spine are extremely rare. Because of biological heterog e n e i t y, these tumors have variable sensitivity to radiation and chemotherapy. Adequate local contro l t h rough complete tumor removal is an important therapeutic goal. However, aggressive resection of tumors in the spinal column must be coupled with restoration of spinal column stability and minimization of neural deficits. The balance of these factors makes treatment of primary sarcomas of the spine challenging, and dictates an individual approach to treatment. We report on a 18 years old man with primary Ewing´s s a rcoma of the nonsacral spine. The clinical picture and imaging characteristics were analyzed as well as the management modalities and outcome.KEY WORDS: Ewing´s sarcoma, primary spine tumor, spine stabilization. Sarcoma de Ewing primário da coluna vertebral: relato de casoRESUMO -Sarcomas malignos primários da coluna são extremamente raros. Devido sua heterogeneidade biológica, estes tumores apresentam sensibilidade variada à radioterapia e à quimioterapia.O contro l e local adequado através da ressecção tumoral completa é um objetivo terapêutico importante. Contudo, a ressecção completa dos tumores da coluna vertebral deve ser realizada com a restauração da estabilidade espinhal e minimização do déficit neurológico. O equilíbrio entre estes fatores torna o tratamento dos sarcomas da coluna desafiador, exigindo-se uma abordagem individualizada para o tratamento de cada paciente. Relatamos um caso de sarcoma de Ewing da coluna não-sacral em um homem de 18 anos. O q u a d ro clínico e características de imagem foram analisados, bem como a modalidades de manejo e o prognóstico.PALAVRAS-CHAVE: sarcoma de Ewing, tumor espinhal, estabilização espinhal. P r i m a ry malignant sarcomas of the spine are extremely rare. It has been estimated that they account for only 3.5% to 14.9% of all primary bone sarc om a s 1 -5 . In the study of primary vertebral Ewing's sarcoma (ES), the division of the spine into nonsacral a n d sacral is important and is dictated by the diff e re n t behavior of ES in these two regions in terms of re sponse therapy and survival rates 4 . Most studies on ES involving the mobile spine are limited to case re p o rt s . A few larger series evaluated patients with primary ES affecting the mobile and nonmobile spine 1 , 6 -9 . Mic roscopic examination demonstrates small, ro u n d blue cells with a uniform appearance. Electron micro sc o p y, immunohistochemistry, and cytogenetic studies help diff e rentiate ES from other small, round blue ceel tumors. The translocation t(11;22)(q24;q12) is identified in most cases of ES 1 0 . Adequate tre a t m e n t of primary malignant spine tumors is aimed at cure rather than palliation whenever possible. The definitive management of Ewing's sarcoma of the spine, as in other locations, could include three main modalities: surg e ry, radiotherapy, and combination chemotheraphy 1 . The purpose of the current study is to re p o rt the diagnosis an...

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“…Cortical blindness, retinopathy, and peripheral neuropathy reent for as little as 48 hours. 19,20 Traditionally, therapy for impending neurosulting in visual deficits have been reported as toxic complications of cisplatin therapy. [26][27][28][29][30][31] It is interesting blastoma-associated visual loss includes radiation and/or high dose steroids to decompress the optic to note that in these reports, patients who developed optic neuritis, rather than retinopathy, with subsenerve(s), thereby preventing any further damage.…”

Section: / 7b8a$$1408mentioning

confidence: 99%