Prognosis in chronic lymphocytic leukemia: a retrospective multicentric study from the GIMEMA group.

Abstract

Clinical and biological data were evaluated using Desu univariate analyses or Cox multivariate analyses in a series of 1,777 chronic lymphocytic leukemia (CLL) patients from an Italian Cooperative Group. In univariate analyses, age and sex of patients, presence of bone marrow (BM; greater than or equal to 50%), and peripheral blood (PB; greater than or equal to 60,000/microL) lymphocytosis, anemia (hemoglobin [Hb] less than 11 g/dL), thrombocytopenia (less than 100,000/microL), direct Coombs' test positivity, hepatomegaly, splenomegaly, and extent of lymph node involvement were shown to be of significant prognostic value. Multivariate analyses, through a stepwise procedure, showed that the most important prognostic variables are Hb, hepatomegaly, lymph node involvement, PB lymphocytosis, and age and sex of patients. Further covariates would produce an improvement having a nonsignificant P value. Based on the results of multivariate analyses, a four-step staging using the significant variables of the Cox model is proposed.

Autoimmune cytopenia does not predict poor prognosis in chronic lymphocytic leukemia/small lymphocytic lymphoma†

“…This result is similar to that of Mauro et al, who found that AIHA presented prior to CLL in 36.5% of patients and that DAT-positive AIHA had no independent prognostic significance in CLL [5]. However in that study, 63% of patients with AIHA had hgb > 10, suggesting that the better prognosis may be due to the lesser degree of anemia rather than the autoimmune etiology as concluded in an earlier report by an Italian cooperative group [28]. In our study of moderate to severe AIHA (hgb < 10) and ITP (platelet count < 100 × 10 3 / l), the better prognosis of the patients with autoimmune cytopenia compared to bone marrow failure, was not due to a lesser severity of cytopenia.…”

Ethnicity variables in the incidence rates of leukemias in New Zealand populations: Implications for stem‐cell transplantation

“…Similarly, a comparison of the ratio of males to females demonstrates that there is a predominance of males, 57% versus. 43%, which is also consistent with other published analyses of CLL incidence [8][9][10]. The NZCR data were also compared to Australian data, and the two countries showed similar age demographics and no significant difference for the incidence of leukemia overall, ALL, AML, CML, or CLL [11].…”

Proliferação monoclonal B CD5+ subclínica

“…O número médio de linfócitos ao diagnóstico era 20 x 10 9 /L, com variação entre 10 e 43,7 x 10 9 /L, enquanto no final do seguimento o número médio era 20.6 x 10 9 /L com variação entre 1 e 47 x 10 9 /L. Mandelli et al 15 descreveram o mesmo tipo de evolução em 327 pacientes com estágio Rai 0 em um total de 1.777 casos de LLC.…”