Prognosis of Chronic Lymphocytic Leukemia: Analysis of One Hundred Cases

Molica, Stefano; Puzzonia, Pasquale; Iannaccaro, Piergiorgio; Pane, Carmela; Alberti, Antonio

doi:10.1177/030089168407000502

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…7 of them survived less than 5 yr (mean 39.5 months, range -19-58). Although these figures are related to a small proportion of patients (n = 16), the foregoing discrepancy has recently been emphasized by other authors too (2,(11)(12)(13)(14)(15)(16)(17)(18). The small number of deaths due to progression of stage A CLL, is, of course, not suitable for reliable analysis; but it does not exclude the criteria for stage A early progression, gained on a larger number of patients by other authors (16)(17)(18).…”

Section: Resultsmentioning

confidence: 92%

B‐chronic lymphocytic leukaemia in Latvia: Epidemiological aspects

Yavorkovsky

Terebkova

Nikulshin

et al. 1993

European J of Haematology

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As in western Europe and the USA, chronic lymphocytic leukaemia (CLL) in Latvia is the most prevalent type of leukaemia. A total of 1509 newly diagnosed cases of B‐cell chronic lymphocytic leukaemia entered the study, 440 of whom were followed up at the Latvian Haematology Centre. The main peculiarities of the study were: 1) the higher incidence of the disease in Latvia as compared with other regions of the former USSR and with western countries, 2) a lower male‐to‐female ratio than in most other countries and 3) a higher morbidity among the Latvian population in comparison with the Russian. A positive correlation between the disease stage and survival was confirmed, but no precise individual prognosis in an early stage of the disease was possible.

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Section: Resultsmentioning

confidence: 92%

B‐chronic lymphocytic leukaemia in Latvia: Epidemiological aspects

Yavorkovsky

Terebkova

Nikulshin

et al. 1993

European J of Haematology

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“…A question may be raised whether the prognostic differences reported in clinical stagings for CLL (1)(2)(3)(4)(5) are due to intrinsic variabilities in the biology of the disease or merely reflect the timing of diagnosis (earlier or later). We have attempted to answer this question by studying the diagnostic latency (DL) in 221 CLL patients.…”

Section: Introductionmentioning

confidence: 99%

Timing of diagnosis and lymphocyte accumulation patterns in chronic lymphocytic leukemia: Analysis of their clinical significance

Molica

Reverter

Alberti

et al. 1990

European J of Haematology

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Molica S, Reverter JC, Alberti A, Montserrat E. Timing of diagnosis and lymphocyte accumulation patterns in chronic lymphocytic leukemia: Analysis of their clinical significance. Eur J Haematol 1990: 44: 277-281.Abstract: In order to evaluate the clinical significance of the timing of diagnosis in chronic lymphocytic leukemia (CLL), we studied the diagnostic latency (DL), a variable related both to lymphocyte count and to lymphocyte doubling time (LDT), which points out the interval between the date of CLL diagnosis and the time at which it could have been made (lymphocyte count in peripheral blood of at least 5.0 x 109/l). In two different series accounting for 221 previously untreated CLL patients the trends of the DL tended to decrease as the risk increased. In other words, the more advanced the clinical stage the shorter the DL. On the other hand, the values of lymphocyte accumulation rate (LAR), which defines the speed at which the number of lymphocytes increases over the time, were significantly lower in earlier stages of disease. Both DL and LAR had a significant impact on survival when investigated by means of univariate analysis. In a Cox's regression analysis applied to a training set of 122 patients, the combination of international clinical stages, LAR and age had the strongest value in predicting survival. The resulting model was validated in an independent subset of 99 patients (test-set cases) leading to a classification of patients into low-, intermediate-, and high-risk groups with 5-year survival rates of 89 % , 3 1 % and 8 % , respectively, and with distinctively different annual mortality rates (p < 0.001). Finally, when multivariate analysis was applied to study disease progression, LAR was the first variable to enter the regression model (p = 0.0001).

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Prognostic value of the lymphocyte doubling time in chronic lymphocytic leukemia

Molica¹,

Alberti²

1987

Cancer

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110

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The prognostic value of lymphocyte doubling time (LDT), expressed in months and obtained by means of a linear regression, has been studied in 99 previously untreated chronic lymphocytic leukemia (CLL) patients. LDT is defined as the period of time needed for lymphocytes to double in number the amount found at diagnosis. When the analysis was extended to the whole population, it showed clear differences in the life expectancy of patients with LDT of less than or equal to 12 months (median survival, 36 months; relative death rate [O/E]1.57) compared with those with LDT of more than 12 months (median survival not yet reached; O/E, 0.37) (P less than 0.001). The significance of LDT remained even after adjustments were made for age, sex, lymphocyte count, anemia, and thrombocytopenia. The lack of statistical significance after adjustment for Binet's clinical stage corresponds to the fact that clinical stages are not distributed homogeneously, high LDT being more frequently associated with earlier stages and low LDT with more advanced forms of the disease (P less than 0.001). In this study LDT was a useful parameter in predicting disease progression. Patients in Stages A and B and with rapidly increasing lymphocytes counts became worse more frequently (33.3% and 29.1%, respectively, at 12 months after diagnosis) than those with a slow increase (no change in clinical stage at 12 months). It is concluded that since LDT appears to predict the progression of the disease, it is useful in the clinical management of CLL.

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Prognosis of Chronic Lymphocytic Leukemia: Analysis of One Hundred Cases

Cited by 6 publications

References 13 publications

B‐chronic lymphocytic leukaemia in Latvia: Epidemiological aspects

B‐chronic lymphocytic leukaemia in Latvia: Epidemiological aspects

Timing of diagnosis and lymphocyte accumulation patterns in chronic lymphocytic leukemia: Analysis of their clinical significance

Prognostic value of the lymphocyte doubling time in chronic lymphocytic leukemia

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