Prognosis of Dialysed Patients after Kidney Transplant Failure

Szabó, Réka P.; Klenk, Nóra; Balla, József; Asztalos, László; Szabó, L.; Vokó, Zoltán

doi:10.1159/000350140

Cited by 8 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous reports show that the prognosis of patients with graft failure is controversial, with some reporting a poorer prognosis compared with transplant‐naïve patients, while others report a comparable prognosis [4–7]. Considering data from registered patients in Japan [21], the survival rate in this study does not appear to be inferior to that of transplant‐naïve dialysis patients (survival rates at 1, 3, and 5 years were 96.0% vs. 89.9%, 93.8% vs. 76.4%, and 82.4% vs. 60.8%, respectively) [21].…”

Section: Discussionmentioning

confidence: 54%

“…Some reports suggest that patients undergoing dialysis for graft failure have a poorer prognosis than transplant-naïve patients [4,5]. Conversely, some reports indicate no difference in mortality rates between post-graft failure dialysis patients and transplant-naïve patients [6,7]. Notably, patients undergoing dialysis for graft failure, unplanned initiation, and initiation using a central venous catheter (CVC) are associated with poor outcomes [8,9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Initiation of dialysis for kidney graft failure: A retrospective single‐center cohort study

et al. 2021

View full text Add to dashboard Cite

Few studies have focused on the outcome of dialysis for kidney graft failure.We investigated the outcomes of dialysis for graft failure. We retrospectively studied 52 patients undergoing dialysis for graft failure at our facility from January 2004 to December 2018. The mean age at initiation of dialysis was 51.8 ± 13.5 years. The patient survival rates after initiation of dialysis at 1, 3, and 5 years were 96.0%, 93.8%, and 82.4%, respectively. The rate of unplanned initiation was 44.2%. In multivariate logistic analysis, lack of follow-up by nephrologists and pre-emptive kidney transplantation (PEKT) tended to be risk factors for unplanned initiation (P = 0.065 and P = 0.014, respectively). Our study suggests that the prognosis of patients with dialysis for graft failure is acceptable. Dialysis for graft failure, especially in patients with PEKT, tends to be unplanned, and for safe initiation, early involvement of nephrologists may be necessary.

show abstract

Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Initiation of dialysis for kidney graft failure: A retrospective single‐center cohort study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…We believe that repeated kidney transplant recipients should be evaluated separated from the first kidney transplant patients. They are considered as higher risk patients with higher morbidity and mortality rates (17,9) and it is important to evaluate if KDPI can be used as a "risk marker" for graft loss also in the case of repeated transplantation. Our findings suggest that KDPI influences the outcomes of repeated kidney transplantation -higher KDPI is associated with worse graft function and lower graft survival rates.…”

Section: Discussionmentioning

confidence: 99%

Kidney Donor Profile Index in the Case of Repeated Transplantation

Gritane

Jushinskis

Maļcevs

et al. 2017

Acta Chirurgica Latviensis

View full text Add to dashboard Cite

Introduction. In 2014, new scoring system - Kidney Donor Profile Index (KDPI) was introduced. KDPI is a numerical measure that combines ten donor factors, including clinical parameters and demographics, to summarize into a single number the quality of deceased donor kidneys. There are some publications regarding usefulness of KDPI in the first kidney transplant recipients, however there are no data focusing on repeated transplantation patients. Aim of the Study. To determine the usefulness of kidney donor profile index as a risk marker of graft failure in repeated transplantation situations. Material and methods. A single-centre retrospective study was conducted. Patients who underwent a repeated transplantation from deceased donors between 2005. and 2013. were included in the study. Data about donor’s risk factors - age, height, weight, race, history of hypertension, history of diabetes, cause of death, serum creatinine, anti-HCV and if donor is after cardiac death - were collected and KDPI was calculated for all participants. Patients were divided into groups according to determined KDPI: Group 1 - KDPI <35%; Group 2 - KDPI 36 - 69%; Group 3 - KDPI >70%. For statistical analysis, IBM Statistical Package for the Social Sciences, version 21.0 was used. Results. A total of 72 patients were enrolled in the study. There were 17 patients (23.6%) in the 1. group, 38 patients (52.8%) in the 2. group and 17 patients (23.6%) in the 3. group. The most common cause of an end stage renal disease was chronic glomerulonephritis- 59.7% (n=43). Patients with higher KDPI developed acute rejection more often. In the group with KDPI <35% it was observed in 35.3%, while in the groups with KDPI 36 - 69% and KDPI >70% in 60.5% and 64.7% of patients, p = 0.02. Graft function differed significantly both, after one (p =0.01) and three years (p=0.04) with the highest eGFR results in the group with the lowest KDPI. The difference in graft survival rates was statistically significant, p = 0.027. After three- years it was 88.2% in the first group, 86.8% in the second group and 70.6% in the third group. Patient survival rates showed trend toward significance (p = 0.076) with only two patients lost during three- year follow up. Conclusions. KDPI presents relevance with repeated transplantation outcomes. Lower KDPI indicates better transplantation outcomes - superior graft function and better graft survival. However, there is only trend towards significance in patient survival rates.

show abstract

“…Egyes kutatások, köztük egy, a Debreceni Egyetem Klinikai Központjában végzett vizsgálat is, arra az eredményre jutottak, hogy a graftectomizált betegek jobb túléléssel bírnak [8,9].…”

Section: Eredeti Közleményunclassified

“…Más szerzők statisztikailag jobb vesetúlélést közöl-tek a második transzplantáció előtt nem graftectomizált betegek esetében, de ez a vizsgálat a miénkhez képest jelentősen nagyobb esetszámon alapult [25]. A betegtúl-élést vizsgálva sem kaptunk szignifikáns különbséget a két csoport között, szemben más forrásokkal, ahol azt találták, hogy a graftectomia javítja a retranszplantáció utáni túlélést [8,9]. Saját vizsgálatainknál a trendek egyeztek.…”

Section: áBra Graftectomizált éS Nem Graftectomizált Betegek Túléléséunclassified

Graftectomiák a debreceni vesetranszplantációs programban

et al. 2016

Self Cite

View full text Add to dashboard Cite

Bevezetés: A graftectomia indikációja és pontos időzítése bizonyos esetekben vita tárgya, elsősorban a tüneteket nem okozó, már nem működő graftok esetén. Célkitűzés: A szerzők átfogó képet kívántak adni a debreceni veseátültetési programban elvégzett graftectomiákról. Módszer: Retrospektív vizsgálattal elemezték a 2004. január 1. és 2015. december 31. között veseátültetett betegek adatait. Áttekintették a graftectomiák indikációit, időzítését, szövődménye-it, továbbá összehasonlították a korai és késői graftectomiákat. Eredmények: A vizsgált időszakban 480 veseátültetés történt. Közülük 55 betegnél (11%) történt graftectomia. A gyakoribb indikációk a következők voltak: krónikus allograft-nephropathia (47%), artériás keringési zavar (13%), ureterszövődmények (9%). A grafteltávolítás 22 betegnél (40%) akut, 33-nál (60%) tervezett volt. A graftectomiák 24%-a a transzplantáció után 30 napon belüli, 76%-a késői volt. Korai graftectomiát túlnyomórészt artériás keringészavar (31%), a későiek többségét (62%) krónikus allograftnephropathia miatt végezték. Következtetések: A vizsgált időszakban a graftectomiák leggyakoribb oka krónikus allograft-nephropathia volt. Az esetek döntő többségében elektív műtét történt. A szakirodalomban közöltekhez hasonlóan a szerzők a korai és késői graftectomiák jellemzőit eltérőnek találták. Orv. Hetil., 2016, 157(24), 964-970. Kulcsszavak: vesetranszplantáció, graftelégtelenség, veseallograft-túlélés, graftectomia Allograft nephrectomy -a single-center experienceIntroduction: Indication and timing of allograft nephrectomy is still uncertain in some cases. Aim: The aim of the authors was to summarize their experience with graftectomies. Method: Data from patients who underwent kidney transplantation between January 1, 2004 and December 31, 2015 were retrospectively analyzed. Frequency, indications, timing, complications as well as early and late allograft nephrectomies were reviewed. Results: From 480 renal transplants, 55 graftectomies were performed (11%). Frequent indications included chronic allograft nephropathy (47%), arterial blood supply complications (13%), ureter complications (9%). 22 cases (40%) of allograft nephrectomies were urgent while 33 cases (60%) were elective. 24% of graftectomies were performed within 30 days after transplantation and 76% thereafter. Conclusions: The main indications for early graftectomies were arterial complications (31%) and chronic allograft nephropathy (62%) in cases of late graftectomies. The majority of the graftectomies were elective. Leading indication was chronic allograft nephropathy. Early and late graftectomies have different characteristics.

show abstract

Prognosis of Dialysed Patients after Kidney Transplant Failure

Cited by 8 publications

References 23 publications

Initiation of dialysis for kidney graft failure: A retrospective single‐center cohort study

Initiation of dialysis for kidney graft failure: A retrospective single‐center cohort study

Kidney Donor Profile Index in the Case of Repeated Transplantation

Graftectomiák a debreceni vesetranszplantációs programban

Contact Info

Product

Resources

About