Prognosis of medication-related osteonecrosis of the jaws in cancer patients using antiresorptive agent zoledronic acid

Wei, Ling-Ying; Kok, Sang‐Heng; Lee, Yen-Ching; Chiu, Wei‐Yih; Wang, Jai-Jen; Cheng, Shih‐Jung; Chang, Hao-Hueng; Lee, Jang‐Jaer

doi:10.1016/j.jfma.2020.11.017

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…Watters et al found a ratio between smoking (p = 0.03) and BAONJ progression by x(2) test 9 .Others report that concomitant use of BP and smoking may prolong the duration of complete remission of the BAONJ lesion 10 . Smoking can still be a confusing factor, given that smokers tend to have poorer oral hygiene than non-smokers.In a recent study, only 2 of the 146 patients diagnosed with medication-related osteonecrosis of the jaws (MRONJ) were smokers, maybe due to the fact that during the treatment period with Zoledronic acid patients were advised to quit smoking and alcohol drinking 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Međutim, smernice za prevenciju OVUB-a/OVUL-a i dalje uključuju kontrolu faktora rizika, kao što su pušenje i alkohol 17 i ograničavanje ili prestanak rizičnog ponašanja za oralno zdravlje, poput pušenja i upotrebe droga i alkohola. Kada postoji rizik, ove smernice odmah se preporučuju, zbog rizika od razvoja OVUB-a [18][19][20] , čak iako za neka istraživanja nisu klinički potkrepljena 21 .…”

Section: Discussionunclassified

“…Pušenje i dalje može biti zbunjujući faktor, s obzirom na to da pušači imaju goru oralnu higijenu od nepušača. U nedavnoj studiji, samo 2 pacijenta od 146 pacijenata, kod kojih je dijagnostifikovana osteonekroza vilice udružena sa lekovima (OVUL), bili su pušači, možda zbog činjenice da je tokom perioda lečenja zoledronskom kiselinom pacijentima savetovano da prestanu sa pušenjem i konzumacijom alkohola 11 .…”

Section: Diskusijaunclassified

“…However, the guidelinesfor prevention of BAONJ/MRONJ continue to involve controlling the risk factors such as smoking and alcohol 17 and limiting or ceasing oral health risk behaviors such as smoking and drug and alcohol use are promptly recommended when at risk for development of BAONJ [18][19][20] even if for some researchers it is not evidence-based 21 .…”

Section: Zahvalnicementioning

confidence: 99%

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Smoking and alcohol consumption as risk factors in 112 oncology patients diagnosed with bisphosphonate-associated osteonecrosis of the jaw

Hristamyan¹,

Raycheva²,

Hristamyan³

2021

Acta stomatologica Naissi

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Background: Bisphosphonate-associated osteonecrosis of the jaws (BAONJ) is a complication of great medical importance. Some of the most discussed and controversial aspects are the risk factors, some of which are related to patients' smoking and alcohol consumption. The Aim: To study cancer patients with BAONJ and determine their participation in the mentioned above risky health-related habits. Material and methods: A prospective epidemiological study of 112 patients diagnosed with bisphosphonate-associated osteonecrosis of the jaw in 2016 and 2017 was conducted at the Clinic of Maxillofacial surgery of University hospital "St. George", Plovdiv, Bulgaria, based on anamnesis, clinical examination, and hospital documentation. SPSS Statistics v.24 was used for statistical analysis, at a significance level p<0.05. Results: Over 2/3 of the patients were smokers (40.18%) or ex-smokers (25.00%), which linked them with the risk factor of smoking. At the time of the study, patients smoking between 1 and 9 and between 10 and 19 cigarettes a day had equal relative shares of 44.22%. More than half of the patients smoked from the age of 20-39, which we explain by the high average age. The majority of patients studied consumed alcohol, most often once a week or on weekends (28.57%) or only on occasions (26.79%), followed by 24.11% who used alcohol several times per week. Nearly 2/3 drink drinks with both low and high alcohol content. Conclusion: The highest proportion of patients are smokers / ex-smokers and consume alcoholic beverages occasionally, which links them to these risk potential factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionunclassified

Section: Diskusijaunclassified

Section: Zahvalnicementioning

confidence: 99%

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Smoking and alcohol consumption as risk factors in 112 oncology patients diagnosed with bisphosphonate-associated osteonecrosis of the jaw

Hristamyan¹,

Raycheva²,

Hristamyan³

2021

Acta stomatologica Naissi

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“…Conservative management concentrates on patient education and motivation, reassurance, control of pain and infection ( Ruggiero et al, 2022 ) while surgical intervention involves removing the infected areas and this require margins beyond the borders of the necrotic bone to an area of vital, bleeding bone ( Ruggiero et al, 2022 ). The prognosis of the disease depends on the cancer type and MRONJ among multiple myeloma patients showed poorer healing compared to breast and prostate cancers ( Wei et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA in medication related osteonecrosis of the jaw: a review

et al. 2023

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Medication related osteonecrosis of the jaw (MRONJ) is a condition caused by inhibition of the osteoclast activity by the anti-resorptive and anti-angiogenic drugs. Clinically, there is an exposure of the necrotic bone or a fistula which fails to heal for more than 8 weeks. The adjacent soft tissue is inflamed and pus may be present as a result of the secondary infection. To date, there is no consistent biomarker that could aid in the diagnosis of the disease. The aim of this review was to explore the literature on the microRNAs (miRNAs) related to medication related osteonecrosis of the jaw, and to describe the role of each miRNA as a biomarker for diagnostic purpose and others. Its role in therapeutics was also searched. It was shown that miR-21, miR-23a, and miR-145 were significantly different in a study involving multiple myeloma patients as well as in a human-animal study while miR-23a-3p and miR-23b-3p were 12- to 14-fold upregulated compared to the control group in an animal study. The role of the microRNAs in these studies were for diagnostics, predictor of progress of MRONJ and pathogenesis. Apart from its potential diagnostics role, microRNAs have been shown to be bone resorption regulator through miR-21, miR-23a and miR-145 and this could be utilized therapeutically.

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The adjunctive use of Leukocyte-Platelet Rich Fibrin (L-PRF) in the management of Medication Related Osteonecrosis of the Jaw (MRONJ): a retrospective observational study

Aslam,

Pitros,

Liew

et al. 2024

Oral Maxillofac Surg

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Prognosis of medication-related osteonecrosis of the jaws in cancer patients using antiresorptive agent zoledronic acid

Cited by 7 publications

References 34 publications

Smoking and alcohol consumption as risk factors in 112 oncology patients diagnosed with bisphosphonate-associated osteonecrosis of the jaw

Smoking and alcohol consumption as risk factors in 112 oncology patients diagnosed with bisphosphonate-associated osteonecrosis of the jaw

MicroRNA in medication related osteonecrosis of the jaw: a review

The adjunctive use of Leukocyte-Platelet Rich Fibrin (L-PRF) in the management of Medication Related Osteonecrosis of the Jaw (MRONJ): a retrospective observational study

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