Prognosis of ovarian clear cell carcinoma compared to other histological subtypes: A meta-analysis

Demographic Clinical and Prognostic Factors of Primary Ovarian Adenocarcinomas of Serous and Clear Cell Histology—A Comparative Study

“…Furthermore, type of adjuvant chemotherapy (in older studies) and whether patients received treatment or not were not accounted for in most studies. 23 Interestingly, the only randomized clinical trial 24 examining the prognosis of early stage oCCC versus oSAC according to postsurgery treatment (no treatment or platine-based adjuvant chemotherapy) found a worse prognosis among oCCC cases as compared with oSAC in the treatment arm, whereas no difference in overall survival or progression free survival was found in the observation arm (no adjuvant chemotherapy). Furthermore, this study found a significantly improved overall survival among oSAC in the treatment arm compared with oSAC in the observation arm, whereas no difference between the 2 arms was observed for oCCC.…”

Ovarian Cancer: A Heterogeneous Disease

“…CCC are rare, accounting for 3.7-12.1% of all EOC. Some studies showed that CCC have the worst prognosis of all EOC [41], even though Bamias et al [8] were unable to identify any prognostic difference to HGSC. CCC present at a younger age than SC, and have a clear association with endometriosis [42][43][44].…”

Vascular Endothelial Growth Factor (VEGF) Polymorphisms and Serum VEGF Levels in Women With Epithelial Ovarian Cancer, Benign Tumors, and Healthy Ovaries

“…It might be supporting data of the well-known poorer prognosis of OCCC. 29,30 Wong et al 31,32 observed differences in VEGF expression between several histological subtypes, and they showed higher levels in serous subtypes of benign and malignant tumors. Unlike our results, this could be explained because they only recruited 2 patients with OCCC.…”