Prognosis of patients with endometrial cancer or atypical endometrial hyperplasia after complete remission with fertility-sparing therapy

Ga, Hiromi; Taguchi, Ayumi; Honjoh, Harunori; Nishijima, Akira; Eguchi, Satoko; Miyamoto, Yuichiro; Sone, Kenbun; Mori, Mayuyo; Osuga, Yutaka

doi:10.1007/s00404-023-07077-7

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…In previous studies, after the initial fertility preservation operation, some patients still face a high risk of hysterectomy due to vaginal atresia or cervical stenosis atresia caused by repeated operations or infection ( 19 , 20 ). Additionally, the risk of reatresia exists when the wound is not covered with appropriate materials after cervicoplasty and vaginoplasty ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of laparoscopic vaginoplasty with peritoneal flaps and cervicoplasty in patients with congenital cervical and complete vaginal atresia: a pilot study

Liu,

Zhang,

Wang

et al. 2024

Quant Imaging Med Surg

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Background Hysterectomy places a considerable physical and mental burden on young female patients with congenital cervical and complete vaginal atresia. Thus, it is necessary to develop a method to detach the obstruction and simultaneously preserve the vagina and uterus in these patients. This study sought to evaluate the efficacy and safety of laparoscopic vaginoplasty using peritoneal flaps and cervicoplasty in patients with congenital cervical and complete vaginal atresia. Methods Between April 2013 and June 2022, nine patients with congenital cervical and complete vaginal atresia at Henan Provincial People’s Hospital were enrolled in this prospective study. All patients were treated with laparoscopic vaginoplasty using peritoneal flaps and cervicoplasty. Baseline clinical data (e.g., age and uterus size) were collected. The surgical success rate and adverse events were assessed. Results The nine enrolled patients had a median age of 15.0 [interquartile range (IQR), 14.0–18.0] years, and five of these patients had pelvic adhesions. The surgeries were successful in all (9/9) patients, with the vagina, uterus, and a normal menstrual cycle being preserved. After a median follow-up duration of 48 months, the neovaginas had a median length of 7.5 cm. Postoperative complications occurred in three of patients and were cured with the appropriate treatment. The five married patients reported being satisfied with their sex life. Conclusions The study preliminarily demonstrated the efficacy of laparoscopic vaginoplasty using peritoneal flaps and cervicoplasty in patients with congenital cervical and complete vaginal atresia. However, due to the small sample size, lack of a control group, and relatively high incidence of adverse events, further studies are still needed to verify these results. Regardless, our findings establish an approach for preserving both the vagina and uterus for patients with congenital cervical and complete vaginal atresia.

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Section: Discussionmentioning

confidence: 99%