Prognosis of synchronous and metachronous multiple primary lung cancers: Systematic review and meta-analysis

Jiang, Long; He, Jiaxi; Shi, Xiaoshun; Shen, Jianfei; Liang, Wenhua; Yang, Chenglin; He, Jianxing

doi:10.1016/j.lungcan.2014.12.013

Cited by 87 publications

(86 citation statements)

References 37 publications

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“…Bu veriler günümüz-de multipl primer akciğer tümörü saptanan olgularda öncelikle adeno kanser tanısının akla gelmesine neden olmaktadır. [62,63] Multipl akciğer kanserli olguların doğru tanımlan-ması, evrelenmesi ve tedavinin planlanması hastalığın prognozu açısından büyük önem taşımaktadır.…”

Section: Multipl Akciğer Tümörleriunclassified

“…[63] "Senkron" ya da "metakron kanser ayrımı yıllar-dır üzerinde tartışılan bir konudur. İlk kez Martini …”

Section: Multipl Akciğer Tümörleriunclassified

“…analizleri ile mutasyonal profil ile senkron/ metakron/metastatik kanser ayırımında yararlı olabilir ancak tek başına kullanılmaması diğer patolojik değerlen-dirmeler ile birlikte kullanılması önerilmektedir. [62,63] Bu olguların sistemik evrelemeleri ayrıntılı ve titizlikle yapılmalı, evrelemede beyin MRG ve PET-BT'nin özellikle cerrahi tedavi planlanan olgularda rutin kullanımı önerilmektedir. Mediastinal lenf nodu tutulumu (N 2 , N 3 ) ve uzak metastaz taraması açısından PET-BT'de önerilmektedir.…”

Section: Senkron Multipl Primer Akciğer Kanseri (Senkron Kanser)unclassified

“…[61] Aynı histolojiye sahip senkron tümörlerde tanı için patolojik örneklerde ileri moleküler incelemeler / genetik incelemeler kullanılabilir. [61][62][63] Evrelemede senkron tümörlerin her biri ayrı ayrı evrelenmeli ve en yüksek evreli tümöre göre tedavi stratejisi multidisipliner konseylerce belirlenmelidir. [60][61][62] …”

Section: Senkron Multipl Primer Akciğer Kanseri (Senkron Kanser)unclassified

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The eighth staging system of non-small cell lung cancer and its practical implications

Turna¹

2017

Turk Gogus Kalp Dama

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ÖZEvreleme akciğer kanserli hastalara yaklaşımın önemli bir kısmını oluşturmaktadır. Tümör sınıflandırmasının esas amacı hastalığın anatomik yaygınlığını doğru olarak ortaya koymaktır. Tümörün anatomik yaygınlığı tedavi seçimi ve prognoz üzerinde önemli bir etkiye sahiptir. Küçük hücreli dışı akciğer kanserinde hastalara genel yaklaşım; mediastenin evrelenmesi ve toraks dışı evreleme için evreleme yöntemlerini, öykü ve fizik muayene, görüntüleme, minimal invaziv teknikler ve invaziv cerrahi teknikleri içermektedir. Mevcut akciğer kanseri evreleme sistemi tümör, lenf nodu ve metastaz (TNM) sınıflamasının Ocak 2017'de kullanılmaya başlanan sekizinci baskısıdır. Bu makalede, küçük hücreli dışı akciğer kanserinde evreleme yöntemleri ile birlikte mevcut TNM tanımlayıcıları ve evre grupları için tanımlar gözden geçirildi. Değişen T, N ve M tanımlayıcılarının hastalarda tedavi seçeneklerini daha iyi işaret edebildiği ve sağkalımı daha doğru bir şekilde öngörebildiği görülmektedir.Anah tar söz cük ler: Sekizinci evreleme sistemi; akciğer kanseri; M faktörü; N faktörü; T faktörü. ABSTRACTStaging is an essential part of the approach to patients with lung cancer. The primary goal of the tumor classification is to correctly describe the anatomic extent of the disease. The anatomic extent of the tumor has a major impact on the treatment selection and prognosis. The general approach to patients with non-small cell lung cancer include mediastinal staging and non-thoracic staging methods, history and physical examination, imaging, minimally invasive techniques, and invasive surgical techniques. The current lung cancer staging system is the eighth edition of the tumor, node, and metastasis (TNM) classification, which was took effect in January 2017. In this article, staging methods and the definitions for current T, N, M descriptors and the stage groups in non-small cell lung cancer are reviewed. New definitions of T, N, and M factors seem to better indicate the most optimal treatment option for an individual patient and to better predict the survival in patients.

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Section: Multipl Akciğer Tümörleriunclassified

“…[63] "Senkron" ya da "metakron kanser ayrımı yıllar-dır üzerinde tartışılan bir konudur. İlk kez Martini …”

Section: Multipl Akciğer Tümörleriunclassified

Section: Senkron Multipl Primer Akciğer Kanseri (Senkron Kanser)unclassified

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The eighth staging system of non-small cell lung cancer and its practical implications

Turna¹

2017

Turk Gogus Kalp Dama

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“…An increasing number of studies has shown benefits from surgical intervention with regard to an early accurate diagnosis and timely treatment with curative intent in patients with synchronous multiple primary lung cancers (SMPLCs) (1,2).…”

Section: Introductionmentioning

confidence: 99%

Single-stage bilateral pulmonary resections by video-assisted thoracic surgery for multiple small nodules

Yao¹,

Yang²,

Zhao³

2016

J. Thorac. Dis.

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Background: Surgical treatment is thought to be the most effective strategy for multiple small nodules.However, in general, one-stage bilateral resection is not recommended due to its highly invasive nature.Methods: Clinical records of patients undergoing one-stage bilateral resections of multiple pulmonary nodules between January 2009 and September 2014 in a single institution were retrospectively reviewed.Results: Simultaneous bilateral pulmonary resection by conventional video-assisted thoracic surgery (VATS) was undertaken in 29 patients. Ground glass opacity (GGO) accounted for 71.9% (46/64) of total lesions, including 26 pure GGO and 20 mixed GGO lesions. One case underwent bilateral lobectomy that was complicated by postoperative dyspnea. Lobar-sublobar (L/SL) resection and bilateral sublobar resection (SL-SL) were conducted in 16 and 12 cases, respectively, and most of these cases had uneventful postoperative courses.There was no significant difference with regard to postoperative complications (P=0.703), duration of use of chest drains (P=0.485), between one-and two-stage groups. Mean postoperative follow-up in cases of primary lung cancer was 31.4 (range, 10-51) months. There was neither recurrence nor deaths at final follow-up. Conclusions Materials and methods PatientsThe study was approved by the ethics committee of Shanghai Chest Hospital. During the period of Jan 1 2009 to Sep 30 2014, cases performed with various pulmonary resections at our department were retrospectively reviewed. Twenty nine cases underwent single-stage bilateral operations of multiple pulmonary nodules were identified. For comparison, 89 patients with bilateral multiple nodules who underwent two-stage operations at the same period were also reviewed. Clinical and histologic features and surgical outcomes were studied. Surgical procedureGeneral anesthesia with double-lumen endotracheal intubation was administered.Single-stage bilateral surgical treatment by video-assisted thoracic surgery (VATS) was applied based on the following rules: patients with good performance status, patient's informed consent, characteristics of multiple pulmonary foci and individual surgeon's experience. The choice of surgical types comprehensively depends on the site of tumors, the evaluation of cardiopulmonary function reserve and outcomes of intraoperative frozen sections. Single-stage resection was performed with starting on the side of the less invasive resection, such as segmentectomy and wedge resection, generally depending on the size and morphology on preoperative chest computed tomography (CT). For planed bilateral sublobar resections, the priority was given to the right side.The patient was placed in the lateral decubitus position. After a one-sided procedure, the patient was rotated to the opposite side for a second resection. Cushions were used to lift the patient to avoid kicking or compression to the contralateral chest tube during positioning. Multiple primary lung cancer was diagnosed based on Martini-Melamed criteria (3).The comp...

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Clinicopathological features, prognostic factor analysis, and survival nomogram of patients with double primary cancers involving lung cancer

Hao,

Zhang,

Cui

et al. 2024

Cancer Medicine

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BackgroundAlthough the incidence of double primary cancers (DPCs) involving lung cancer is rising, they have not been studied sufficiently. This study retrospectively analyzed the clinicopathological and prognostic characteristics of DPC patients with lung cancer and developed a survival nomogram to predict the individual OS rates.MethodsWe included 103 DPC patients with lung cancer from Shengjing Hospital between 2016 and 2021. Based on the 6‐month cancer occurrence interval, the cases were categorized as synchronous DPCs (sDPCs) or metachronous DPCs (mDPCs). Furthermore, the mDPCs were subdivided based on whether the lung cancer occurred first (LCF cohort) or the other cancer occurred first (OCF cohort).ResultsAmong the patients, 35 (33.98%) and 68 (66.02%) had sDPCs and mDPCs, respectively. In the mDPCs cohort, 18 (26.47%) belonged to the LCF cohort and 50 (73.53%) to the OCF cohort. The most frequent primary cancer sites were the breast (27.18%), colorectum (22.33%), and urinary system (18.45%). Independent risk factors for progression‐free survival were Stage IV lung cancer (p = 0.008) and failure to undergo radical lung cancer surgery (p = 0.028). The risk factors for OS included squamous carcinoma (p = 0.048), Stage IV lung cancer (p = 0.001), single cancer resection plus drug therapy (p < 0.001), drug therapy alone (p = 0.002), failure to undergo radical lung cancer surgery (p = 0.014), and chemotherapy (p = 0.042). The median OS was 37 months, with 3‐ and 5‐year rates of 50.9% and 35.9%, respectively.ConclusionDPCs involving lung cancer account for 1.11% of cases. The breast, colorectum, and urinary system were the most common extra‐pulmonary sites, and mDPCs were more frequent than sDPCs. Radical lung cancer surgery significantly affects prognosis, and drug therapy alone may be preferable when only one tumor is operable. The developed nomogram can accurately predict individual 3‐year and 5‐year OS rates.

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Prognosis of synchronous and metachronous multiple primary lung cancers: Systematic review and meta-analysis

Cited by 87 publications

References 37 publications

The eighth staging system of non-small cell lung cancer and its practical implications

The eighth staging system of non-small cell lung cancer and its practical implications

Single-stage bilateral pulmonary resections by video-assisted thoracic surgery for multiple small nodules

Clinicopathological features, prognostic factor analysis, and survival nomogram of patients with double primary cancers involving lung cancer

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