2024
DOI: 10.1159/000540790
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Prognostic and Clinical Significance of the Proliferation Marker MCM7 in Breast Cancer

Ayat G. Lashen,
Michael S. Toss,
Catrin S. Rutland
et al.

Abstract: Introduction: Minichromosome maintenance complex component 7 (MCM7) plays an essential role in proliferation and DNA replication of cancer cells. However, the expression and prognostic significance of MCM7 in breast cancer (BC) remain to be defined. In this study, we aimed to evaluate the role of MCM7 in BC. Methods: We conducted immunohistochemistry staining of MCM7 in 1,156 operable early-stage BC samples and assessed MCM7 at the transcriptomic levels using publicly available cohorts (n = 13,430). MCM7 expre… Show more

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