Prognostic and Clinical Significance of Cyclooxygenase-2 Overexpression in Endometrial Cancer: A Meta-Analysis

Li, Mingli; Li, Mingxuan; Yan-gang, Wei; Xu, Hua

doi:10.3389/fonc.2020.01202

Cited by 10 publications

(9 citation statements)

References 46 publications

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“…Cyclooxygenase-2 (COX-2) regulates the synthesis of prostaglandins. In EC patients COX-2 overexpression was positively associated with EC stage [97]. There was an inverse relationship between COX-2 expression and the frequency of CD8+ T cells in tumors.…”

Section: Regulation Of Endometrial Cancer By Cell Surface Receptors and Soluble Moleculesmentioning

confidence: 87%

Tissue Infiltrating Immune Cells and Endometrial Cancer Prognosis

Drakes¹,

Mehrotra²,

Potkul³

et al. 2021

COR

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The number of patients diagnosed with endometrial cancer surpasses that of any other gynaecological cancer. This disease is usually detected early after disease onset and with current therapy 80 percent of patients with early-stage disease reach a five-year survival milestone. However, patients with advanced or recurrent disease have a grim outcome and the five-year survival rate for these patients is only about 16 percent. In several cancer types there is accumulating evidence that immune cells play a crucial role in the initiation, progression and outcome of disease. In order to provide novel and effective immunotherapeutic treatments for advanced disease endometrial cancer, an understanding of the relevance of immune cells needs to be addressed. This review briefly discusses current knowledge in the area of immune cells and how they may alter the course of endometrial cancer, as well as the implications of these cells for novel therapy and outcome.

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Section: Regulation Of Endometrial Cancer By Cell Surface Receptors and Soluble Moleculesmentioning

confidence: 87%

Tissue Infiltrating Immune Cells and Endometrial Cancer Prognosis

Drakes¹,

Mehrotra²,

Potkul³

et al. 2021

COR

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“…It is expressed in normal tissues and in many cancers and performs a pleiotropic and multifaceted function in carcinogenesis. [15][16][17] COX2 is involved in regulates resistance to apoptosis, cancer cell proliferation and invasion, angiogenesis, inflammation, and metastasis. Inhibition of the activity of these proteins may contribute to the regression of a malignant tumor, which is a promising therapeutic method in modern oncology.…”

Section: Introductionmentioning

confidence: 99%

ER and COX2 expression in endometrial hyperplasia processes

Tsyndrenko,

Lyndіn,

Sikora

et al. 2023

Medicine

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Endometrial hyperplastic processes (EHPs) encompass various morphological changes, characterized by an increased ratio of endometrial glands to stroma. These changes manifest as endometrial hyperplasia (EH) and endometrial polyps. The objective of this study was to investigate the expressions of ER and Cyclooxygenase-2 (COX2) in EH and endometrial polyps, and determine their correlation with histological and anthropometric parameters. Tissue samples were obtained during hysteroresectoscopy and divided into 3 groups: non-atypical EH, glandular EP, and glandular-fibrous EP. We examined the immunoprofile of epithelial and stromal cells using rabbit polyclonal anti-COX2 antibodies and rabbit monoclonal anti-ER antibodies (clone SP1). Our results indicate that there is no association between the expressions of ER and COX2 and the type of EHP. Furthermore, the expression levels of ER and COX2 are not influenced by the patients anthropometric parameters. However, tissues with EHPs exhibited significantly higher COX2 expression compared to intact tissues. We also observed a direct correlation between ER and COX2 expression in the endometrial epithelium. The variability in ER and COX2 expressions observed in hyperplastic processes of the endometrium potentially suggests their synergistic involvement in the initiation and progression of EHPs, as well as their potential role in subsequent tumor transformation.

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“…The effects of prostanoids are physiologically mediated by GPCR receptors responsible for cancer progression. COX‐2 overexpression is upregulated in several human cancers suggesting that it plays an important role in pathophysiology of various cancers such as lung, [17] breast, [18] colorectal, [19] genitourinary, prostate, stomach, [20] ovarian [21] endometrial [22] and cervical cancers [23] . The angiogenic effect of COX‐2 can be blocked by selective COX‐2 inhibitors, and this may contribute to a decrease in tumor formation.…”

Section: Introductionmentioning

confidence: 99%

Structural Insights into Pyrazoles as Agents against Anti‐inflammatory and Related Disorders

et al. 2022

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Pyrazole moiety is considered as the most important therapeutic agent for the treatment of inflammation and inflammation associated cancers. Celecoxib, Ramifenazone, Rimonabant and Lonazolac are some of the commercially available pyrazole moieties which are potent COX‐2 inhibitors and also acts in inhibiting various cancers. Recently there are numerous reviews on the biological significance of pyrazole derivatives. However, this review discusses pyrazole derivatives possessing anti‐inflammatory and anticancer activity (COX inhibition) and also illustrates the recent updates on pyrazole research emphasizing on the medicinal chemistry aspects such as the key structural fragments required for the biological activity. There are series of pyrazoles like di‐substituted, tri‐substituted, tetra‐substituted pyrazoles, pyrazole hydrazones, pyrazoles bearing various other heterocycles, bicyclic fused pyrazoles, tricyclic fused pyrazoles, and miscellaneous class of pyrazoles. All these pyrazoles are being researched as COX inhibitors, anti‐inflammatory and against related disorders like cancer.

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Prognostic and Clinical Significance of Cyclooxygenase-2 Overexpression in Endometrial Cancer: A Meta-Analysis

Cited by 10 publications

References 46 publications

Tissue Infiltrating Immune Cells and Endometrial Cancer Prognosis

Tissue Infiltrating Immune Cells and Endometrial Cancer Prognosis

ER and COX2 expression in endometrial hyperplasia processes

Structural Insights into Pyrazoles as Agents against Anti‐inflammatory and Related Disorders

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