Prognostic and Clinicopathological Significance of Telomerase Reverse Transcriptase Upregulation in Oral Cancer: A Systematic Review and Meta-Analysis

González‐Moles, Miguel Ángel; Moya-González, Eloísa; García-Ferrera, Alberto; Nieto-Casado, Paola; Ramos‐García, Pablo

doi:10.3390/cancers14153673

Cited by 7 publications

(4 citation statements)

References 71 publications

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“…It is interesting to note that pTERT mutation cancers do not often occur on the floor of the month in in‐house cohort, which may provide insight into OCSCC carcinogenesis. pTERT mutations are known to amplify the expression of TERT protein in tissues, 21 and a review by González‐Moles et al 22 stated that TERT protein expression may be a better factor than gene mutation, but TERT mutation is present in the promoter, a finding that is missed by conventional coding region sequencing. We have not found a report that comprehensively describes the relationship between pTERT mutations, their mRNA expression, and TERT protein immunostaining in oral cancer.…”

Section: Discussionmentioning

confidence: 99%

TERT promoter mutation positive oral cavity carcinomas, a clinically and genetically distinct subgroup of head and neck squamous cell carcinomas

Saito,

Kage,

Kobayashi

et al. 2023

Head & Neck

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BackgroundsThe importance of TERT promoter (pTERT) mutation of oral cavity squamous cell carcinoma (OCSCC) with clinical features and genetic alterations are not well recognized.MethodsWe retrospectively analyzed genetic data from multiple databases, including 260 cases from the C‐CAT database, 407 cases from the MSK‐MetTropism database, and 40 OCSCC datasets from in‐house clinical samples.ResultsFrom C‐CAT database, TP53 (66%), CDKN2A (51%), and pTERT (29%) were the most frequent mutations observed. pTERT mutations were more prevalent in OCSCC (63%), younger individuals, and women (46%), with lower rates of alcohol abuse and smoking and co‐mutated with TP53, HRAS, and CASP8. MSK‐MetTroposim data validated with the enrichment of pTERT mutations in OCSCC, among women and Asian individuals. In‐house datasets OCSCC with pTERT mutation (50%) characterized by fewer recurrent neck metastases.ConclusionThe study suggests that OCSCC with pTERT mutation represents a distinct subgroup with unique clinical and genetic characteristics.

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Section: Discussionmentioning

confidence: 99%

TERT promoter mutation positive oral cavity carcinomas, a clinically and genetically distinct subgroup of head and neck squamous cell carcinomas

Saito,

Kage,

Kobayashi

et al. 2023

Head & Neck

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“…By this mechanism, reduced telomerase activity in the early stages of malignant transformation, in which only the functions of tumor-suppressor genes would fail, would facilitate by telomere shortening the acquisition of cancer-linked nonclonal chromosomal aberrations; later, telomerase activation would promote the survival and expansion of fully established malignant clones [ 166 , 167 ]. It should be pointed out that this important mechanism linked to malignant transformation and progression has been very little studied based on the evidence in oral cancer [ 168 ], there being no information (systematic reviews, meta-analyses or primary-level studies) regarding OLP malignization.…”

Section: Discussionmentioning

confidence: 99%

Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses

González‐Moles

Pino

Ramos‐García

2022

IJMS

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Oral lichen planus (OLP) is a common chronic inflammatory disease of unknown etiology and likely autoimmune nature that is currently considered an oral potentially malignant disorder, implying that patients suffering from this process are at risk of developing oral cancer in their lifetime. The molecular alterations that develop in OLP and that make the affected oral epithelium predisposed to malignancy are unknown, although, as in other autoimmune diseases (ulcerative colitis, primary biliary cirrhosis, etc.), they may be linked to oncogenesis-promoting effects mediated by the inflammatory infiltrate. So far there is no in-depth knowledge on how these hallmarks of cancer are established in the cells of the oral epithelium affected by OLP. In this scoping review of systematic reviews and meta-analyses the state of evidence based knowledge in this field is presented, to point out gaps of evidence and to indicate future lines of research. MEDLINE, Embase, Cochrane Library and Dare were searched for secondary-level studies published before October 2022. The results identified 20 systematic reviews and meta-analyses critically appraising the hallmarks tumor-promoting inflammation (n = 17, 85%), sustaining proliferative signaling (n = 2, 10%), and evading growth suppressors (n = 1, 5%). No evidence was found for the other hallmarks of cancer in OLP. In conclusion, OLP malignization hypothetically derives from the aggressions of the inflammatory infiltrate and a particular type of epithelial response based on increased epithelial proliferation, evasion of growth-suppressive signals and lack of apoptosis. Future evidence-based research is required to support this hypothesis.

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“…The RoB was considered low, moderate, or high for each domain. Finally, an overall score was also estimated based on a method previously described by our research group [ 26 , 27 , 28 , 29 ], in order to statistically analyze the influence of the methodological quality of primary-level studies on our meta-analytical results, thus estimating pooled effect sizes adjusted for risk of bias.…”

Section: Methodsmentioning

confidence: 99%

Prognostic and Clinicopathological Significance of the Loss of Expression of Retinoblastoma Protein (pRb) in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

López-Ansio

Ramos‐García

González‐Moles

2023

Cancers

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This systematic review and meta-analysis aims to evaluate the scientific evidence on the implications of retinoblastoma protein (pRb) alterations in oral cancer, in order to determine its prognostic and clinicopathological significance. PubMed, Embase, Web of Science, and Scopus were searched for studies published before February 2022, with no restrictions by publication date or language. The quality of the studies using the Quality in Prognosis Studies tool (QUIPS tool). Meta-analysis was conducted to achieve the proposed objectives, as well as heterogeneity, subgroup, meta-regression, and small study-effects analyses. Twenty studies that met the inclusion criteria (2451 patients) were systematically reviewed and meta-analyzed. Our results were significant for the association between the loss of pRb expression and a better overall survival (HR = 0.79, 95%CI = 0.64–0.98, p = 0.03), whereas no significant results were found for disease-free survival or clinico-pathological parameters (T/N status, clinical stage, histological grade). In conclusion, our evidence-based results demonstrate that loss of pRb function is a factor associated with improved survival in patients with OSCC. Research lines that should be developed in the future are highlighted.

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Prognostic and Clinicopathological Significance of Telomerase Reverse Transcriptase Upregulation in Oral Cancer: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 71 publications

TERT promoter mutation positive oral cavity carcinomas, a clinically and genetically distinct subgroup of head and neck squamous cell carcinomas

TERT promoter mutation positive oral cavity carcinomas, a clinically and genetically distinct subgroup of head and neck squamous cell carcinomas

Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses

Prognostic and Clinicopathological Significance of the Loss of Expression of Retinoblastoma Protein (pRb) in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

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