Prognostic and diagnostic value of elevated serum concentration of procalcitonin in patients with suspected heart failure. A review and meta-analysis

Aïssou, Linda; Sorbets, Emmanuel; Lallmahomed, Elisa; Goudot, François‐Xavier; Pop, Natalia; Es-sebbani, Sanae; Benouda, Leila; Meune, Christophe

doi:10.1080/1354750x.2018.1443511

Cited by 8 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…26 Elevated serum PCT levels predict the risk of short-term mortality in patients with heart failure. 27 In addition, PCT levels are superior to CRP levels and pro-adrenomedullin (MR-proADM) levels for predicting adverse cardiovascular events and all-cause mortality in patients with type 2 diabetes. 28 Recent studies have suggested that PCT is an independent marker of fat accumulation and metabolic parameters associated with obesity status.…”

Section: Discussionmentioning

confidence: 99%

Elevated PCT at ICU discharge predicts poor prognosis in patients with severe traumatic brain injury: a retrospective cohort study

et al. 2020

View full text Add to dashboard Cite

Purpose Disease severity and inflammatory response status are closely related to a poor prognosis and must be assessed in patients with severe traumatic brain injury (STBI) before intensive care unit (ICU) discharge. Whether elevated serum procalcitonin (PCT) levels can predict a poor prognosis in STBI patients before ICU discharge is unclear. Methods This retrospective observational cohort study enrolled 199 STBI patients who were in the ICU for at least 48 hours and survived after discharge. Based on serum PCT levels at discharge, patients were divided into the high-PCT group (PCT ≥ 0.25 ng/mL) and the low-PCT group (PCT < 0.25 ng/mL). We assessed the relationship between serum PCT levels and a poor prognosis. Results The high-PCT group had a higher rate of adverse outcomes compared with the low-PCT group. Multivariate logistic regression analysis showed that the Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, white blood cell (WBC) count, C-reactive protein (CRP) level, and PCT level at discharge were significantly associated with adverse outcomes. Conclusions Elevated PCT levels at ICU discharge were associated with a poor prognosis in STBI patients. The serum PCT level as a single indicator has limited value for clinical decision-making.

show abstract

Section: Discussionmentioning

confidence: 99%

Elevated PCT at ICU discharge predicts poor prognosis in patients with severe traumatic brain injury: a retrospective cohort study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A recent longitudinal analysis of 86,000 individuals with incident HF also specifically identified infections as an important opportunity to positively impact HF prognosis [9]. The prevention of hospital-acquired infections, early detection of infection using procalcitonin, early initiation of optimal antibiotics, and adequate duration of therapy may prevent and reduce risk of hospital readmissions in patients with HF [14,16,24,25]. The data for procalcitonin for guiding antibiotic decision making remains mixed, but has been more consistently shown to aid in antibiotic de-escalation or discontinuation [26,27].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the characterization of the type of infections that affect patients hospitalized for HF is limited. Describing the epidemiology of infectious complications, especially bacterial infections, and their impact on outcomes is important to understanding how this comorbidity could be targeted to further improve HF outcomes [14]. This study aims to describe the epidemiology of acute infections, specifically bacterial pathogens, as these represent the most common etiology for infected patients hospitalized for HF [15,16], and to evaluate their associations to longitudinal HF outcomes.…”

Section: Introductionmentioning

confidence: 99%

Acute Bacterial Infections and Longitudinal Risk of Readmissions and Mortality in Patients Hospitalized with Heart Failure

Bae-Shaaw

et al. 2022

JCM

View full text Add to dashboard Cite

Aims: Infections are associated with worse short-term outcomes in patients with heart failure (HF). However, acute infections may have lasting pathophysiologic effects that adversely influence HF outcomes after discharge. Our objective was to describe the impact of acute bacterial infections on longitudinal outcomes of patients hospitalized with a primary diagnosis of HF. Methods and Results: This paper is based on a retrospective cohort study of patients hospitalized with a primary diagnosis of HF with or without a secondary diagnosis of acute bacterial infection in Optum Clinformatics DataMart from 2010–2015. Primary outcomes were 30 and 180-day hospital readmissions and mortality, intensive care unit admission, length of hospital stay, and total hospital charge, compared between those with or without an acute infection. Cohorts were compared after inverse probability of treatment weighting. Multivariable logistic regression was used to examine relationship to outcomes. Of 121,783 patients hospitalized with a primary diagnosis of HF, 27,947 (23%) had a diagnosis of acute infection. After weighting, 30-day hospital readmissions [17.1% vs. 15.7%, OR 1.11 (1.07–1.15), p < 0.001] and 180-day hospital readmissions [39.6% vs. 38.7%, OR 1.04 (1.01–1.07), p = 0.006] were modestly greater in those with an acute infection versus those without. Thirty-day [5.5% vs. 4.3%, OR 1.29 (1.21–1.38), p < 0.001] and 180-day mortality [10.7% vs. 9.4%, OR 1.16 (1.11–1.22), p < 0.001], length of stay (7.1 ± 7.0 days vs. 5.7 ± 5.8 days, p < 0.001), and total hospital charges (USD 62,200 ± 770 vs. USD 51,100 ± 436, p < 0.001) were higher in patients with an infection. Conclusions: The development of an acute bacterial infection in patients hospitalized for HF was associated with an increase in morbidity and mortality after discharge.

show abstract

“…The rationale to choose NLR and PLR was based on the promising results in other settings 11 , 12 . PCT was chosen to include one established marker of systemic inflammation as comparison that may also be useful in patients with cardiac disease 15 . All markers were measured within 24 h after VA-ECMO initiation.…”

Section: Methodsmentioning

confidence: 99%

Neutrophil-lymphoycyte-ratio, platelet-lymphocyte-ratio and procalcitonin for early assessment of prognosis in patients undergoing VA-ECMO

Roth

M‘Pembele

Stroda

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasing, but mortality remains high. Early assessment of prognosis is challenging and valid markers are lacking. This study aimed to investigate Neutrophil–Lymphocyte Ratio (NLR), Platelet-Lymphocyte-Ratio (PLR) and Procalcitonin (PCT) for early assessment of prognosis in patients undergoing VA-ECMO. This retrospective single-center cohort study included 344 consecutive patients ≥ 18 years who underwent VA-ECMO due to cardiogenic shock. Main exposures were NLR, PLR and PCT measured within 24 h after VA-ECMO initiation. The primary endpoint was all-cause in-hospital mortality. In total, 92 patients were included into final analysis (71.7% male, age 57 ± 14 years). In-hospital mortality rate was 48.9%. Receiver operating characteristics (ROC) curve revealed an area under the curve (AUC) of 0.65 [95% confidence interval (CI) 0.53–0.76] for NLR. The AUCs of PLR and PCT were 0.47 [95%CI 0.35–0.59] and 0.54 [95%CI 0.42–0.66], respectively. Binary logistic regression showed an adjusted odds ratio of 3.32 [95%CI 1.13–9.76] for NLR, 1.0 [95%CI 0.998–1.002] for PLR and 1.02 [95%CI 0.99–1.05] for PCT. NLR is independently associated with in-hospital mortality in patients undergoing VA-ECMO. However, discriminative ability is weak. PLR and PCT seem not to be suitable for this purpose.

show abstract

Prognostic and diagnostic value of elevated serum concentration of procalcitonin in patients with suspected heart failure. A review and meta-analysis

Abstract: In patients with HF, an elevated serum PCT concentration predicted the short-term risk of death.

Cited by 8 publications

References 31 publications

Elevated PCT at ICU discharge predicts poor prognosis in patients with severe traumatic brain injury: a retrospective cohort study

Elevated PCT at ICU discharge predicts poor prognosis in patients with severe traumatic brain injury: a retrospective cohort study

Acute Bacterial Infections and Longitudinal Risk of Readmissions and Mortality in Patients Hospitalized with Heart Failure

Neutrophil-lymphoycyte-ratio, platelet-lymphocyte-ratio and procalcitonin for early assessment of prognosis in patients undergoing VA-ECMO

Contact Info

Product

Resources

About