Prognostic and diagnostic value of circRNA expression in prostate cancer: A systematic review and meta-analysis

Abstract

BackgroundCircular RNAs (circRNAs) are receiving increasing attention as novel biomarkers. Our goal was to investigate the diagnostic, clinicopathological, and prognostic utility of circRNAs in prostate cancer (PCa).MethodsRelevant literature was searched in PubMed, Web of Science, and EMBASE. Sensitivity, specificity, diagnostic odds ratio (DOR), negative likelihood ratio (NLR), positive likelihood ratio (PLR), and the area under the curve (AUC) were calculated to evaluate the diagnostic accuracy of circRNA expression. circRNAs’ clinical, pathological, and prognostic value was examined using pooled odds ratios (ORs) and hazard ratios (HRs).ResultsThis meta-analysis included 23 studies, with 5 for diagnosis, 16 for clinicopathological parameters, and 10 for prognosis. For diagnostic value, the pooled sensitivity, pooled specificity, PLR, NLR, DOR, and AUC were 0.82, 0.62, 2.17, 0.29, 7.37, and 0.81, respectively. Upregulation of carcinogenic circRNAs was associated with poor clinical parameters (Gleason score: OR = 0.222, 95% CI: 0.145–0.340; T classification: OR = 0.274, 95% CI: 0.175–0.430; lymph node metastasis: OR = 0.353, 95% CI: 0.175–0.716; tumor size: OR = 0.226, 95% CI: 0.099–0.518) and could predict poor survival outcomes (HR = 2.408, 95% CI: 1.559–3.720, p < 0.001). Conversely, downregulation of tumor-suppressor circRNAs was also associated with poor clinical parameters (Gleason score: OR = 1.689, 95% CI: 1.144–2.493; T classification: OR = 2.586, 95% CI: 1.779–3.762) and worse prognosis (HR = 1.739, 95% CI: 1.147–2.576, p = 0.006).ConclusionOur results showed that circRNAs might be useful biomarkers for the diagnosis and prognosis of PCa.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021284785.

circPVT1 Inhibits the Proliferation and Aids in Prediction of the Prognosis of Bladder Cancer

“…Recent studies have shown that circRNAs play an important role in their occurrence and have become a research hotspot. [3][4][5] circRNA plasmacytoma variant translocation 1 (circPVT1), transcribed from the long noncoding RNA region with PVT1 locus on chromosome 8q24, is upregulated to drive the development of various cancers. 6,7 PVT1 from online data analysis was abnormally expressed in BLCA.…”

Transmission and Infection of Arboviruses

“…Since its first isolation from mosquitoes in Hainan Province, China in 1964, it has broken out and become prevalent in 17 provinces and cities (Zhai et al, 2008). So far, the virus RNA or antibodies have been detected in horses, pigs, cattle, sheep, blue foxes, kangaroos, monkeys, red pandas, and some poultry (Nemoto et al, 2015;Li et al, , 2019Yang et al, 2018;Ren et al, 2020;Xing et al, 2020;Rattanatumhi et al, 2022;Shi et al, 2022a;Zhao et al, 2022). Of particular note is that neutralizing antibodies against GETV have been found in human serum in Malaysia, Australia, and China (Zhai et al, 2008;Shi et al, 2022b), and the specific antibody titers in febrile populations are significantly higher than in healthy populations, indicating that GETV infection is related to human diseases.…”

Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain

“…circRNAs, which act as miRNA sponges, adsorb miRNAs and further regulate the expression of mRNAs, which is the most studied function of circRNAs (Hansen et al, 2013). circRNA-miRNA-mRNA has been proven to play an important role in chronic diseases such as cancer, brain tissue disease, and vascular disease (Wang et al, 2021;Zhu et al, 2021;Xie et al, 2022). The abnormal expression of circRNA slowly promotes changes in miRNA-mRNA expression and gradually leads to the occurrence of chronic diseases.…”