Prognostic and therapeutic implications of dipyridamole stress cardiovascular magnetic resonance on the basis of the ischaemic cascade

Bodı́, Vicente; Sanchís, Juan; López‐Lereu, María P.; Núñez, Julio; Mainar, Luis; Monmeneu, José V.; Ruíz, Vicente; Rúmiz, Eva; Hüsser, Oliver; Moratal, David; Millet, José; Chorro, Francisco J.; Llàcer, Àngel

doi:10.1136/hrt.2007.139683

Cited by 57 publications

(33 citation statements)

References 25 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2. Eventually, 11 studies [5,6,8,[18][19][20][21][22][23][24][25] fulfilled all inclusion criteria and were eligible for meta-analysis. All eligible studies had been published in peer-reviewed journals between 2004 and 2011.…”

Section: Search Resultsmentioning

confidence: 99%

“…For prognostic utility, six studies evaluated stress cine MRI [5,6,8,19,[21][22] and seven studies evaluated stress p-MRI [6,18,20,[22][23][24][25]. Three studies evaluated both stress cine MRI and stress p-MRI in the same patient groups [6,21,22]. Five studies reported data on both hard cardiac events and MACE [5,6,8,18,23], three studies hard cardiac events only [19,22,24], and three studies MACE only [20,21,25].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Three studies evaluated both stress cine MRI and stress p-MRI in the same patient groups [6,21,22]. Five studies reported data on both hard cardiac events and MACE [5,6,8,18,23], three studies hard cardiac events only [19,22,24], and three studies MACE only [20,21,25]. Methodological quality assessment by NOS was 5-6 stars (Table 1).…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…These patients were followed for 0.8 to 6.2 years (Table 1). For prognostic utility, six studies evaluated stress cine MRI [5,6,8,19,[21][22] and seven studies evaluated stress p-MRI [6,18,20,[22][23][24][25]. Three studies evaluated both stress cine MRI and stress p-MRI in the same patient groups [6,21,22].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Methodological quality assessment by NOS was 5-6 stars (Table 1). Several articles described that the patients received intervention, such as pharmacological treatment for hypertension or hyperlipidaemia, in the follow-up period of stress CMR [6,8,21,22,24,25].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

See 4 more Smart Citations

The Prognostic Value of Normal Stress Cardiovascular Magnetic Resonance Imaging

Iwata

Nakagawa

Ogasawara

2014

Journal of Computer Assisted Tomography

View full text Add to dashboard Cite

None of the authors have any conflicts of interest associated with this study. Abstract ObjectivesThe purpose of our study was to determine the prognostic value of normal stress cardiovascular MRI (CMR) by a systematic literature review and meta-analysis. MethodsA comprehensive literature search of published studies through November 2011 in MEDLINE database and Cochrane Library, regarding prognostic value of stress CMR in patients with known or suspected coronary artery disease (CAD), was performed. ResultsUltimately, we identified 11 studies. The summary relative risk ratio for major adverse cardiac events (MACE) was 0.50 (95% confidence interval (CI): 0.44 to 0.58) for normal cine CMR and 0.09 (95% CI: 0.02 to 0.35) for normal perfusion CMR. The summary relative risk ratio for hard cardiac events was 0.36 (95% CI: 0.16 to 0.8) for normal cine CMR and 0.22 (95% CI: 0.07 to 0.66) for normal perfusion CMR. ConclusionNormal stress CMR for patients known or suspected of having CAD has good prognostic value in predicting cardiac events.

show abstract

Section: Search Resultsmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

See 3 more Smart Citations

The Prognostic Value of Normal Stress Cardiovascular Magnetic Resonance Imaging

Iwata

Nakagawa

Ogasawara

2014

Journal of Computer Assisted Tomography

View full text Add to dashboard Cite

show abstract

Risk of death associated with incident heart failure in patients with known or suspected chronic coronary syndrome

et al. 2022

View full text Add to dashboard Cite

Aims Traditional adverse events in chronic coronary syndrome (CCS) include atherothrombotic events but usually exclude heart failure (HF). Data are scarce about how new‐onset HF modifies mortality risk. We aimed to determine the incidence of HF and compare its long‐term mortality risk with myocardial infarction (MI) and stroke in patients with known or suspected CCS. Methods We prospectively evaluated 5811 consecutive HF‐free patients submitted to vasodilator stress cardiac magnetic resonance (CMR) for known or suspected CCS. Ischaemic burden and left ventricular ejection fraction were assessed by CMR. HF included outpatient diagnosis or acute HF hospitalization. The mortality risk for the incident events and their cross‐comparisons were evaluated using a Markov illness–death model with transition‐specific survival models. Results The mean age was 55 ± 11 years, and 38.9% were female. At a median follow‐up of 5.44 (IQR = 2.53–8.55) years, 591 deaths were registered (1.79 per 100 P‐Y). The rates of new‐onset HF were higher compared with MI and stroke [1.02, 0.62, and 0.51, respectively ( P < 0.05)]. The adjusted association between new‐onset HF, MI, and stroke, and subsequent mortality was time dependent. The risk increased almost linearly for HF and became significant by the third year. By Year 10, the mortality risk attributable to new‐onset HF was more than 2.5‐fold (HR: 2.68, 95% CI = 1.74–4.12). For MI, there was a significant increase in mortality risk up to the second year, followed by a monotonic decrease. For stroke, the mortality risk increased for the entire follow‐up but became significant by the third year. A cross‐comparison among incident endpoints HF outnumbers risk for those with MI by the sixth year (HR year6.3 : 1.88, 95% CI = 1.03–3.43). There was no difference in mortality risk between incident HF and stroke. Conclusions In patients with CCS, long‐term rates of incident HF were higher than MI and stroke. Patients with new‐onset HF showed a higher risk of long‐term mortality.

show abstract

Sex Effect in the Decision to Perform Invasive Coronary Angiography in Patients With Chronic Coronary Syndrome After Undergoing Vasodilator Stress MRI

Palau

Núñez

Monmeneu³

et al. 2022

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background: Stress cardiac MRI permits comprehensive evaluation of patients with known or suspected chronic coronary syndromes (CCS). The impact of sex on the use of invasive cardiac angiography (ICA) after vasodilator stress cardiac MRI is unclear. Purpose: To evaluate the impact of sex on ICA use after vasodilator stress cardiac MRI. Study type: Retrospective. Population: A total of 6229 consecutive patients (age [mean AE standard deviation] 65.2 AE 11.5 years, 38.1% women). Field Strength/Sequence: A 5-T; a steady-state free-precession cine sequence; stress first-pass perfusion imaging; late enhancement imaging. Assessment: Patients underwent vasodilator stress cardiac MRI for known or suspected CCS. The ischemic burden (at stress first-pass perfusion imaging) was computed (17-segment model). Statistical Tests: Multivariate logistic regression was used to evaluate the potential differential association between ischemic burden and use of cardiac MRI-related ICA across sex. Results: A total of 1109 (17.8%) patients were referred to ICA, among which there were significantly more men (762, 19.7%) than women (347, 14.6%). Overall, after multivariate adjustment, female sex was not associated with lower use of ICA (odds ratio [OR] = 0.99; confidence interval [CI] 95%: 0.84-1.18, P = 0.934). However, significant sex differences were detected across ischemic burden. Whereas women with nonischemic vasodilator stress cardiac MRI (0 ischemic segments) were less commonly submitted to ICA (OR = 0.49; CI 95%: 0.35-0.69) in patients with ischemia (>1 ischemic segment), adjusted use of ICA was more frequent in women than men (OR = 1.27; CI 95%: 1.1-1.5). Data Conclusions: In patients with known or suspected CCS submitted to undergo vasodilator stress cardiac MRI, cardiac MRI-related ICA may be overused in men without ischemia. Furthermore, ICA referral in patients with negative ischemia resulted in greater odds of revascularization in men.

show abstract

Prognostic and therapeutic implications of dipyridamole stress cardiovascular magnetic resonance on the basis of the ischaemic cascade

Cited by 57 publications

References 25 publications

The Prognostic Value of Normal Stress Cardiovascular Magnetic Resonance Imaging

The Prognostic Value of Normal Stress Cardiovascular Magnetic Resonance Imaging

Risk of death associated with incident heart failure in patients with known or suspected chronic coronary syndrome

Sex Effect in the Decision to Perform Invasive Coronary Angiography in Patients With Chronic Coronary Syndrome After Undergoing Vasodilator Stress MRI

Contact Info

Product

Resources

About