Prognostic association of frailty with post-arrest outcomes following cardiac arrest: A systematic review and meta-analysis

Mowbray, Fabrice; Manlongat, Donna; Correia, Rebecca H.; Strum, Ryan P.; Fernando, Shannon M.; McIsaac, Daniel I.; Wit, Kerstin de; Worster, Andrew; Costa, Andrew P.; Griffith, Lauren; Douma, Matthew J.; Nolan, Jerry P.; Muscedere, John; Couban, Rachel; Foroutan, Farid

doi:10.1016/j.resuscitation.2021.06.009

Cited by 35 publications

(26 citation statements)

References 57 publications

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“…A systematic review and meta-analysis similar to ours has been recently published. 39 This is a rapidly developing field of research, and one clinicians are more acutely aware of since the COVID-19 pandemic. Our review adds two studies newly published in the past year to a comprehensive meta-analysis, and considers the prognostic influence of increasing CFS score where possible.…”

Section: Discussionmentioning

confidence: 99%

Outcomes in adults living with frailty receiving cardiopulmonary resuscitation: A systematic review and meta-analysis

Hamlyn

Lowry²,

Jackson³

et al. 2022

Resuscitation Plus

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Section: Discussionmentioning

confidence: 99%

Outcomes in adults living with frailty receiving cardiopulmonary resuscitation: A systematic review and meta-analysis

Hamlyn

Lowry²,

Jackson³

et al. 2022

Resuscitation Plus

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“…The CFS has been reported to be predictive in a variety of clinical scenarios, such as cardiopulmonary resuscitation and trauma 43,44 . In some scenarios, however, the CFS may be of limited use compared to estimates of illness acuity, but this is controversial 45 .…”

Section: Discussionmentioning

confidence: 99%

“…The CFS has been reported to be predictive in a variety of clinical scenarios, such as cardiopulmonary resuscitation and trauma. 43,44 In some scenarios, however, the CFS may be of limited use compared to estimates of illness acuity, but this is controversial. 45 For example, CFS did not predict mortality well in patients admitted with COVID-19 in one study, and illness acuity as measured using Early Warning Score outperformed CFS in a similar study.…”

Section: Measures Of Illness Acuity Should Guide Immediate Actions Bymentioning

confidence: 99%

The clinical frailty scale predicts 1‐year mortality in emergency department patients aged 65 years and older

Rueegg

Nissen

Brabrand

et al. 2022

Academic Emergency Medicine

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Frailty is a state of increased vulnerability for poor resolution of homeostasis after a stressor event, so that frail individuals are at risk for adverse health outcomes and prolonged convalescence. 1 In the emergency department (ED), triage acuity predicts the outcomes of ED length of stay, hospitalization, intensive care unit (ICU) admission, and mortality within 30 days, 2 but may be ill-suited for prediction of adverse outcomes beyond this time frame. In a large Danish study, for example, abnormal vital signs were strong risk factors for mortality within the first 2 days, but hereafter, the association declined with time from arrival most rapidly until day 7. 3 Longer term prognostication is likely more dependent on physiological reserve such as the degree of frailty rather than how ill or

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“…Not only were absolute outcomes worse for frail patients but they were more likely to be discharged to a long-term care facility (adjusted OR 1.93 [95% CI 1.57–2.32]) [ 45 ]. Pooled results from meta-analysis found the presence of frailty was associated with an approximate three-fold increase in the odds of dying in-hospital after IHCA (adjusted OR = 2.93; 95% CI = 2.43–3.53)[ 46 ]. Understanding the impact of frailty on outcome is another part of the puzzle informing outcomes and prognosis after IHCA.…”

Section: Prognostic Factors Associated With Survival After Ihca and E...mentioning

confidence: 99%

In-hospital cardiac arrest: the state of the art

Penketh

Nolan

2022

Crit Care

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In-hospital cardiac arrest (IHCA) is associated with a high risk of death, but mortality rates are decreasing. The latest epidemiological and outcome data from several cardiac arrest registries are helping to shape our understanding of IHCA. The introduction of rapid response teams has been associated with a downward trend in hospital mortality. Technology and access to defibrillators continues to progress. The optimal method of airway management during IHCA remains uncertain, but there is a trend for decreasing use of tracheal intubation and increased use of supraglottic airway devices. The first randomised clinical trial of airway management during IHCA is ongoing in the UK. Retrospective and observational studies have shown that several pre-arrest factors are strongly associated with outcome after IHCA, but the risk of bias in such studies makes prognostication of individual cases potentially unreliable. Shared decision making and advanced care planning will increase application of appropriate DNACPR decisions and decrease rates of resuscitation attempts following IHCA.

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Prognostic association of frailty with post-arrest outcomes following cardiac arrest: A systematic review and meta-analysis

Cited by 35 publications

References 57 publications

Outcomes in adults living with frailty receiving cardiopulmonary resuscitation: A systematic review and meta-analysis

Outcomes in adults living with frailty receiving cardiopulmonary resuscitation: A systematic review and meta-analysis

The clinical frailty scale predicts 1‐year mortality in emergency department patients aged 65 years and older

In-hospital cardiac arrest: the state of the art

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