Prognostic clinicopathologic factors, including immunologic expression in diffuse large B‐cell lymphomas

Zhang, Anmin; Ohshima, Koichi; Sato, Kensaku; Kanda, Motonobu; Suzumiya, Junji; Shimazaki, Kae; Kawasaki, Chika; Kikuchi, Masahiro

doi:10.1046/j.1440-1827.1999.00980.x

Cited by 63 publications

(62 citation statements)

References 41 publications

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“…On the other hand, p21 expression was concluded to have no prognostic value for predicting breast cancer-related survival or recurrence-free survival (13). Similarly, survival did not differ significantly among groups with a different p21 labeling index (7) and expression of p21 did not influence overall survival and disease-free survival in diffuse large B-cell lymphoma (22). Pruneri el al.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

et al. 2005

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Protein p21 (Waf1/Cip1) plays a critical role in controlling the cell cycle especially as a check point of G1 and is intimately associated with important cellular activities including differentiation, senescence, tumorigenesis, and apoptosis. In the present study, we examined the expression of p21 in multiple myeloma (MM) cells for prognostic evaluation. The immunocytochemical localization of p21 could be categorized into nuclear and cytoplasmic types. The nuclear-type p21 localization was correlated with the severity of MM and the expression of proliferating cell nuclear antigen and p53. Patients with the nuclear-type p21 localization survived significantly shorter than those with the cytoplasmic-type localization. Thus, the present study suggests that p21-immunolocalization can be a useful prognostic marker of MM.

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Section: Discussionmentioning

confidence: 99%

“…The cell cycle inhibitory activity of p21 has been correlated with its nuclear localization (2). Several studies have evaluated the prognostic significance of p21 in hematopoietic (22,24) and solid (1,7,8,11,13,18,19) tumors, but the prognostic evaluation in MM remains to be explored (6,9,15).…”

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confidence: 99%

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

et al. 2005

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“…Multiple studies have looked at the expression of bcl-2 using immunostains and most have found no difference in overall survival. 16,23,[27][28][29][30][31][32][33][34][35] However, some studies have found that bcl-2 expression is associated with a significantly worse overall survival, 3,[36][37][38][39][40][41][42] or event-free survival. [29][30][31]36,37 The discrepancies related to bcl-2 expression and prognosis may be related to the underlying subgroups of DLBCL.…”

Section: Discussionmentioning

confidence: 99%

“…Expression of Ki-67 has been associated with significantly worse overall survival, 31,46-49 significantly better overall survival, [50][51][52] or to have no effect on overall survival in DLBCL. 16,32,53,54 Although we initially used a cutpoint of 50% for Ki-67, we analyzed all possible cut-points using a survival tree method and found no value that had a statistically significant effect on overall survival or event-free survival. 13 A single study has reported that survivin expression is an independent predictor of worse survival in DLBCL.…”

Section: Discussionmentioning

confidence: 99%

Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma

et al. 2005

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We sought to determine whether identification of poor-risk subgroups of diffuse large B-cell lymphoma (DLBCL) using immunohistochemical stains would have practical utility with regard to prognosis and therapeutic decisions. Tissue microarray blocks were created using replicate samples of formalin-fixed, paraffin-embedded tissue from 200 cases of de novo DLBCL. The sections were stained with antibodies to proteins that are expressed by activated or proliferating B cells including MUM1, FOXP1, bcl-2, survivin, protein kinase C-beta (PKC-b), cyclin D2, cyclin D3, and Ki-67. In univariate analysis, tumor expression of cyclin D2 (P ¼ 0.025) or PKC-b (P ¼ 0.015) was associated with a worse overall survival, whereas none of the other markers was predictive of overall survival. Patients with DLBCL that expressed either cyclin D2 or PKC-b had a 5-year overall survival of only 30% as compared to 52% for those who were negative for both markers (P ¼ 0.0019). In multivariate analysis, the expression of cyclin D2 or PKC-b was an independent predictor of poor overall survival (P ¼ 0.035). Cyclin D2 and PKC-b expression will be useful in designing a 'biological prognostic index' for patients with DLBCL.

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“…This may have been due to the sensitivity of the PCR-SSCP technique in archival tissue, or to mutations outside exons 5-9. [48][49][50] Expression of p53 protein has previously been demonstrated in 13% to 70% of DLBCLs, 9,12,[50][51][52] and has been frequently demonstrated in the absence of a mutation. 49,53,54 This may alternatively be explained by p53 stabilization by mechanisms such as mdm2 interaction.…”

Section: Discussionmentioning

confidence: 99%

Germinal center phenotype and bcl-2 expression combined with the International Prognostic Index improves patient risk stratification in diffuse large B-cell lymphoma

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et al. 2002

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The International Prognostic Index (IPI) identifies poor-and good-risk patients with diffuse large B cell lymphoma (DLBCL); however, the majority of patients have an intermediate IPI, with an uncertain prognosis. To determine whether cellular factors can be combined with the IPI to more accurately predict outcome, we have analyzed 177 presentation nodal DLBCLs for the expression of bcl-2 and a germinal center (GC) phenotype (defined by expression of bcl-6 and CD10). P53 gene band shifts were detected using single-stranded conformational polymorphism polymerase chain reaction analysis of exons 5-9 and were correlated with protein expression. In a Cox regression analysis, IPI (R ‫؍‬ 0.22, P < .0001) and bcl-2 (R ‫؍‬ 0.14, P ‫؍‬ .0001) were independent poor prognostic factors and a GC phenotype predicted a favorable outcome (R ‫؍‬ ؊0.025, P ‫؍‬ .02). Neither p53 expression nor band shifts had a significant effect on survival. Using the IPI alone, 8% of patients were identified as high risk.

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Prognostic clinicopathologic factors, including immunologic expression in diffuse large B‐cell lymphomas

Cited by 63 publications

References 41 publications

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

Expression of PKC-beta or cyclin D2 predicts for inferior survival in diffuse large B-cell lymphoma

Germinal center phenotype and bcl-2 expression combined with the International Prognostic Index improves patient risk stratification in diffuse large B-cell lymphoma

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