Prognostic Effect of Lymphovascular Invasion on TNM Staging in Stage I Non–Small-cell Lung Cancer

Noma, Daisuke; Inamura, Kentaro; Matsuura, Yuichiro; Hirata, Yusuke; Nakajima, Takako; Yamazaki, Hirotsugu; Hirai, Yoshimitsu; Ichinose, Junji; Nakao, Masayuki; Ninomiya, Hironori; Mun, Mingyon; Nakagawa, Ken; Masuda, Munetaka; Okumura, Sakae

doi:10.1016/j.cllc.2017.06.001

Cited by 32 publications

(25 citation statements)

References 40 publications

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“…LVI has been considered to be associated with tumor aggressiveness and reported to define outcomes in patients with stage I NSCLC. 25 Wang et al even suggested that we could incorporate LVI as a T descriptor in the next edition of the TNM classification, as VPI. 26 Consistently, we have demonstrated that there is a significant difference in LVI in the part-solid group (p ¼ 0.030), whereas there was a trend in the solid group (p ¼ 0.054).…”

Section: Discussionmentioning

confidence: 99%

Distinct Prognostic Factors in Patients with Stage I Non–Small Cell Lung Cancer with Radiologic Part-Solid or Solid Lesions

Zhang

Wen

et al. 2019

Journal of Thoracic Oncology

143

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Introduction: Recent studies have indicated that the presence of ground-glass opacity (GGO) components is associated with favorable survival. The purpose of this study was to reveal the prognostic value of GGO components and differences in prognostic factors for part-solid and solid lesions in invasive stage I NSCLC. Methods: The cases of 2010 patients with completely resected invasive pathological stage I NSCLC were reviewed according to the eighth edition of the TNM classification. Patients were categorized into the pure-GGO, part-solid, and solid groups based on consolidation-to-tumor ratio. Cox multivariate proportional hazard analyses were conducted to identify independent prognostic factors in each group. Results: Of the 2010 patients, 146 (7.3%) were in the pure-GGO group, 732 (36.4%) were in the part-solid group, and 1132 (56.3%) were in the solid group. Cox multivariate analyses revealed that GGO absence was a strong independent risk factor for worse recurrence-free survival (p < 0.001). For the pure-GGO group, there was no recurrence in spite of the invasive stage. For the partsolid group, visceral pleural invasion could not predict recurrence-free survival in general (p ¼ 0.514) or in each tumor size group (for tumors size 1 cm, p ¼ 0.664; for tumors size >1 to 2 cm, p ¼ 0.456; for tumors size >2 to 3 cm, p ¼ 0.900; and for tumors size >3 to 4 cm, p ¼ 0.397). For the solid group, adenocarcinoma subtype was not a prognostic factor for recurrence-free survival in general (p ¼ 0.162) or in each tumor size group (for tumors size 2 cm, p ¼ 0.092; for tumors size >2 to 3 cm, p ¼ 0.330; and for tumors size >3 to 4 cm, p ¼ 0.885). Conclusions: The presence of GGO components was a strong predictor in patients with invasive pathological stage I NSCLC. Risk factors were distinct in the part-solid and solid groups. There was no prognostic value of visceral pleural invasion in the part-solid group. Adenocarcinoma subtype did not have prognostic value in the solid group.

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Section: Discussionmentioning

confidence: 99%

Distinct Prognostic Factors in Patients with Stage I Non–Small Cell Lung Cancer with Radiologic Part-Solid or Solid Lesions

Zhang

Wen

et al. 2019

Journal of Thoracic Oncology

143

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“…LVI has been involved in TNM classification of some tumors, such as lung cancer, colorectal cancer, gastric cancer, and testicular cancer,22232425 which meant that LVI might have a similar significance in TNM classification. In non-small-cell lung cancer (NSCLC), stage IA with vascular invasion (VI) and stage IB had equivalent prognostic outcomes, suggesting that pT IA NSCLC with VI should be upstaged similar to pT IB NSCLC 22. Ahmed Farag, et al23 found that adding LVI to TNM classification of colorectal cancer could help the physician provide more aggressive treatment strategies for patients with early TNM stage with LVI.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Lymphovascular Invasion in Node-Negative Upper Urinary Tract Urothelial Carcinoma Patients Undergoing Radical Nephroureterectomy

et al. 2019

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PurposeThis study aimed to evaluate the prognostic impact of lymphovascular invasion (LVI) in patients treated with radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC).Materials and MethodsWe collected data from 180 patients who were treated with RNU from 2005 to 2013 at our institution. The Kaplan-Meier method with log-rank test and Cox proportional hazards regression models were used for univariate and multivariate analyses.ResultsLVI was present in 28 patients (15.6%), which was associated with higher pathological tumor stage (p<0.001), tumor necrosis (p=0.012), lymph node metastasis (p=0.017) and multifocality (p=0.012). On multivariate analysis, LVI was an independent prognostic factor of recurrence-free survival [RFS: hazard ratio (HR)=2.954; 95% confidence interval (CI)=1.539–5.671; p=0.001] and cancer-specific survival (CSS: HR=3.530; 95% CI=1.701–7.325; p=0.001) in all patients. In patients with node-negative UTUC, LVI was also a significant predictor of RFS (HR=3.732; 95% CI 1.866–7.464; p<0.001) and CSS (HR=3.825; 95% CI=1.777–8.234; p=0.001).ConclusionLVI status was an independent predictor in patients with UTUC who underwent RNU. The estimate of LVI could help physicians identify high-risk patients and make a better medication regimen of adjuvant chemotherapy.

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“…Surgical and anaesthetic variables were extent of resection (sublobar resection, lobectomy, bilobectomy, or pneumonectomy), uses of thoracoscopic surgery, radical lymph node dissection, intraoperative blood loss, perioperative blood transfusion (during or within 7 days after surgery) 40,41 , and epidural analgesia 38,42 . Pathologic variables were cancer stage, subtype, tumour differentiation, microscopic necrosis, lymphocytic infiltration, lymphovascular invasion, and perineural infiltration 43,44 . We also recorded lung cancer with EGFR mutation.…”

Section: Collection Of Covariatesmentioning

confidence: 99%

A comparison of inflammation markers for predicting oncological outcomes after surgical resection of non-small-cell lung cancer: a validated analysis of 2,066 patients

Chang

et al. 2020

Sci Rep

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Clinical and pathological predictors have proved to be insufficient in identifying high-risk patients who develop cancer recurrence after tumour resection. We aimed to compare the prognostic ability of various inflammation markers in patients undergoing surgical resection of lung cancer. We consecutively included 2,066 patients with stage I–III non-small-cell lung cancer undergoing surgical resection at the center between 2005 and 2015. We evaluated prognostic nutritional index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio along with their perioperative changes. We conducted stepwise backward variable elimination and internal validation to compare the selected markers’ predictive performance for postoperative recurrence-free survival and overall survival. Preoperative neutrophil-to-lymphocyte ratio independently predicts recurrence-free survival (HR: 1.267, 95% CI 1.064–1.509, p = 0.0079, on base-2 logarithmic scale) and overall survival (HR: 1.357, 95% CI 1.070–1.721, p = 0.0117, on base-2 logarithmic scale). The cut-off value is 2.3 for predicting both recurrence (sensitivity: 46.1% and specificity: 66.7%) and mortality (sensitivity: 84.2% and specificity: 40.4%). Advanced cancer stage, poor tumour differentiation, and presence of perineural infiltration were significantly correlated with higher preoperative neutrophil-to-lymphocyte ratio. We concluded that preoperative neutrophil-to-lymphocyte ratio is superior to prognostic nutritional index and platelet-to-lymphocyte ratio in predicting postoperative recurrence and mortality of patients undergoing surgical resection of non-small-cell lung cancer.

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Prognostic Effect of Lymphovascular Invasion on TNM Staging in Stage I Non–Small-cell Lung Cancer

Cited by 32 publications

References 40 publications

Distinct Prognostic Factors in Patients with Stage I Non–Small Cell Lung Cancer with Radiologic Part-Solid or Solid Lesions

Distinct Prognostic Factors in Patients with Stage I Non–Small Cell Lung Cancer with Radiologic Part-Solid or Solid Lesions

Prognostic Value of Lymphovascular Invasion in Node-Negative Upper Urinary Tract Urothelial Carcinoma Patients Undergoing Radical Nephroureterectomy

A comparison of inflammation markers for predicting oncological outcomes after surgical resection of non-small-cell lung cancer: a validated analysis of 2,066 patients

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