Prognostic effect of sarcopenia in colorectal cancer recurrence

Takiguchi, Koichi; Furuya, Shinichi; Sudo, Makoto; Saito, Ryo; Yamamoto, Atsushi; Ashizawa, Naoki; Hirayama, Kazuyoshi; Shoda, Katsutoshi; Akaike, Hidenori; Hosomura, Naohiro; Kawaguchi, Yoshihiko; Amemiya, Hidetake; Kawaida, Hiromichi; Inoue, Satoshi; Kono, Hiroshi; Ichikawa, Daisuke

doi:10.1016/j.nut.2021.111362

Cited by 13 publications

(10 citation statements)

References 29 publications

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“…According to Miyamoto Y et al, sarcopenia was a negative predictor for survival of patients with stage I-III CRC undergoing curative surgery [3]. Furthermore, Takiguchi K et al argued that preoperative sarcopenia was associated with prognosis and prognosis would signi cantly improve after sarcopenia had been alleviated [32]. Additionally, they also reported that not only preoperative but also postoperative nutritional interventions were important for improving sarcopenia, which might thereby improve their survival [32].…”

Section: Discussionmentioning

confidence: 99%

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The impacts of sarcopenia on outcomes of patients with left-sided colon or rectal cancer after curative surgery

et al. 2023

Preprint

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Background The impacts of nutritional status on and short-term and long-term survival of patients with left-sided colon or rectal cancer have not been exhaustively investigated. Thus, we accomplished the present study to evaluate the effects of sarcopenia on short-term and long-term outcomes of patients with left-sided colon or rectal cancer. Methods Patients with pathologically diagnosed stage I, II and III left-sided colon or rectal cancer who had undergone curative surgery were studied. The psoas muscle index (PMI) identified by 3D-image analysis of computed tomographic images was the criterion used to diagnose sarcopenia. The cutoff value recommended by Hamaguchi et al. (PMI value < 6.36 cm2/m2 for men and < 3.92 cm2/m2 for women) was adopted to confirm the diagnosis of sarcopenia. According to PMI, each patient was divided into the sarcopenia group (SG) or the non-sarcopenia group (NSG). Then SG was compared with NSG in terms of short-term outcomes and long-term outcomes. Results Among the 939 patients included, 574 ones (61.1%) were confirmed with preoperative sarcopenia. Initially, it was demonstrated that SG was not significantly different from NSG in terms of most baseline characteristics except smaller body mass index (BMI) (P < 0.001), larger tumor size (P < 0.001) and more weight loss (P = 0.029). Then it revealed that SG had a longer hospital stay after surgery (P = 0.040), more intraoperative blood transfusion (P = 0.035), and a higher incidence of anastomotic fistula (P = 0.027), incision infection (P = 0.037) and hypoalbuminemia (P = 0.022). The SG had significantly worse overall survival (OS) (P = 0.016) and recurrence-free survival (RFS) (P = 0.036) than the NSG. Subsequently, by Cox regression analysis, we revealed that preoperative sarcopenia was an independent predictive factor for worse OS (P = 0.0211, HR = 1.367, 95%CI: 1.049–1.782) and RFS (P = 0.045, HR = 1.299, 95%CI: 1.006–1.677). Conclusion Preoperative sarcopenia significantly adversely affected long-term and short-term outcomes of patients with left-sided colon or rectal cancer and preoperative nutrition supplementation may help us improve their long-term and short-term outcomes.

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Section: Discussionmentioning

confidence: 99%

“…Firstly, improved sarcopenia might increase muscle mass and activity and better muscle activity was associated with better survival [32]. Secondly, improved sarcopenia was likely to result in better course of other diseases such as chronic heart failure, cirrhosis and chronic obstructive pulmonary disease [33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

The impacts of sarcopenia on outcomes of patients with left-sided colon or rectal cancer after curative surgery

et al. 2023

Preprint

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“…Many reports showed that sarcopenia was related to poor RFS or distant metastasis-free survival (DMFS), such as Extrahepatic Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma, nasopharyngeal carcinoma, non-small cell lung cancer, and colorectal cancer. [5,15,[23][24][25]The mean mechanism for this result might be that sarcopenia is associated with immune senescence and reduces cancer immunity, which induces the reduction of immunity to inflammation. The inflammatory microenvironment is changed, which is involved in carcinogenesis and cancer progression [26,27].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, body composition parameters, like SMI and PMI, can influence clinical risk assessment and decision-making in different cancer types. For instance, sarcopenia was shown to be an independent prognostic factor for shorter OS in gastric cancer and colorectal cancer, as well as inferior relapse-free survival (RFS) [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma

Zhao

Fang

et al. 2022

World J Surg Onc

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Objective This investigation aimed to explore the relationship between sarcopenia and severe postoperative complications, relapse-free survival (RFS), and overall survival (OS) in patients with retroperitoneal liposarcoma (RLPS). Material and methods This retrospective study included 72 RLPS patients (47 men, 25 women; mean age, 57.49 years, SD 10.92) who had abdominal CT exams. Clinical information was recorded, including RLPS characteristics (histologic subtypes, grade, size), laboratory assessment (ALB, PALB, A/G, Hb, SCr), relapse-free survival, overall survival, and postoperative complications. The relationships between those variables and RFS and OS were analyzed using Cox proportional hazard models. Results There were 8 severe postoperative complications (Clavien-Dindo grade > 2). The chi-square test showed sarcopenia was associated with severe postoperative complications (P = 0.011). In multivariate analysis, sarcopenia was not associated with relapse-free survival (P = 0.574) and overall survival (P = 0.578). Conclusions Sarcopenia predicts worse surgical complications but does not affect relapse-free survival and overall survival.

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“…The relationship between sarcopenia and the prognosis of various diseases has been studied. Sarcopenia has been noted to be a poor prognostic factor in cancers such as breast and colon cancer [ 4 , 7 , 8 , 9 , 10 ]. The quality and quantity of preoperative skeletal muscle in HNSCC patients reportedly affect patient prognosis [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M

Yoshimura,

Hirano,

Hamada

et al. 2024

Cancers

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Major advances have been made in cancer treatment, but the prognosis for elderly cancer patients with sarcopenia and frailty remains poor. Myokines, which are thought to exert preventive effects against sarcopenia, have been reported to be associated with the prognosis of various cancers, but their effect on head and neck squamous cell carcinoma (HNSCC) is unknown. The aim of this study was to clarify the influence of exercise on the control of HNSCC and to examine the underlying mechanism involved. Mice were injected with HSC-3-M3 cells, a human cell line of highly metastatic and poorly differentiated tongue cancer, at the beginning of the study. Just prior to transplantation, blood was collected from the mice, and the levels of myokines were measured by ELISA. Oncostatin M (OSM), a selected myokine, was added to HSC-3-M3 cells, after which the cell proliferation ability, cell cycle, and protein expression were analyzed in vitro. Tumor cell viability was lower (control: 100%, exercise: 75%), tumors were smaller (control: 26.2 mm3, exercise: 6.4 mm3), and survival was longer in the exercise group than in the control group in vivo. OSM inhibited HSC-3-M3 cell proliferation in a concentration-dependent manner in vitro. The addition of OSM increased the proportion of cells in the G0/G1 phase, decreased the proportion of cells in the G2/M phase, and increased the expression of the CDK inhibitors p21 and p27. These results indicate that exercise may directly inhibit the proliferation of HNSCC cell lines via OSM.

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Prognostic effect of sarcopenia in colorectal cancer recurrence

Cited by 13 publications

References 29 publications

The impacts of sarcopenia on outcomes of patients with left-sided colon or rectal cancer after curative surgery

The impacts of sarcopenia on outcomes of patients with left-sided colon or rectal cancer after curative surgery

Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma

Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M

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