Prognostic efficacy of preoperative mGPS, SIS and LCS in patients with gastric cancer

Chen, Yi-Ru; Chen, Yanling; Ouyang, Su-Shan; Xu, Huiwen; Li, Ping; He, Longjun; Zhu, Shuchai

doi:10.1016/j.cca.2020.09.027

Cited by 17 publications

(16 citation statements)

References 40 publications

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“…Out of 810 unique articles screened, 18 were assessed by their full texts. We excluded 11 studies not fulfilling the inclusion criteria and managed to include seven studies in this review (16)(17)(18)(19)(20)(21)(22).…”

Section: Resultsmentioning

confidence: 99%

“…Another novel marker that has been used in recent years is the SIS. The SIS combines albumin and LMR values and has been noted to be superior to other blood-borne markers like the NLR, modified Glasgow Prognostic Score, and lymphocyte C-reactive protein score for patients with cancer ( 18 , 28 ). Its prognostic ability has also been validated in several cancer subtypes.…”

Section: Discussionmentioning

confidence: 99%

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Can the systemic inflammation score be used to predict prognosis in gastric cancer patients undergoing surgery? A systematic review and meta-analysis

Liu

et al. 2022

Front. Surg.

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BackgroundInflammatory markers are being increasingly used to predict the prognosis of cancer patients. We hereby conducted the first meta-analysis assessing the association between systemic inflammation score (SIS) and prognosis of gastric cancer patients undergoing surgical intervention.MethodsA literature search was carried out on PubMed, CENTRAL, Scopus, and Embase up to 3rd June 2022 for relevant studies. Adjusted data reported as hazard ratios (HR) was combined in a random-effects model.ResultsA total of seven studies with 5,338 patients could be included. All studies were from either China or Japan and published in the last four years. Meta-analysis showed that higher SIS scores (1 or 2) were significant predictors of poor overall survival (OS) in gastric cancer patients (HR: 1.25 95% CI: 1.05, 1.49, I2 = 11%). Similarly, the meta-analysis demonstrated that an SIS score of 2 was associated with poor OS as compared to scores of 0/1 (HR: 2.53 95% CI: 1.30, 4.89, I2 = 45%). Data on disease-free survival (DFS) was scarce to draw conclusions.ConclusionThe SIS score can be a simple and useful tool to predict OS in gastric cancer patients undergoing surgery. Data on DFS is scarce and conflicting. Future studies should report using standard reference groups and provide data on DFS to enhance current evidence.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/#searchadvanced, identifier: CRD42022335548.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Can the systemic inflammation score be used to predict prognosis in gastric cancer patients undergoing surgery? A systematic review and meta-analysis

Liu

et al. 2022

Front. Surg.

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“…10,11 Chen et al found that the lymphocyte CRP level is a useful tool for predicting postoperative mortality in patients with GC. 12 Pang et al reported that a preoperative inflammation-based score could precisely predict LNM in patients with GC. 13 Liu et al developed a nomogram based on CRP/album with a high predictive LNM power in patients with GC with cN0 .…”

Section: Discussionmentioning

confidence: 99%

A potential novel biomarker in predicting lymph node metastasis of gastric signet ring cell carcinoma: A derived monocyte to lymphocyte ratio

Tong¹,

Wang²,

Yang

et al. 2022

The American Journal of Surgery

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Background: This study is designed to evaluate the predictive value of derived monocyte to lymphocyte ratio (dMLR), neutrophil to lymphocyte ratio (NLR) and eosinophil to lymphocyte ratio (ELR) for lymph node metastasis (LNM) in gastric signet ring cell carcinoma (SRCC) patients. Methods: We carried out a retrospective analysis for 203 eligible patients who underwent radical gastrectomy between January 2011 and September 2020. Results: The diagnostic sensitivity and specificity for dMLR were 60.3% and 72.2%, respectively; while for NLR and ELR were 64.1% and 66.6%, and 91.6% and 23.6%, respectively. The dMLR and NLR were identified as independent predictors of LNM, but ELR was not. A nomogram was developed incorporating dMLR and clinical characteristics with AUC of 0.868, and the outcome of DCA supported good clinical benefit. Conclusions: dMLR is a promising novel preoperative biomarker to predict LNM of gastric SRCC.

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“…The combination of systemic inflammatory markers and nutritional markers to predict prognosis and progression of disease has been widely used and proved to be useful, and the representatives include Glasgow prognostic score (GPS), CONUT, and NPS ( 16 , 21 , 50 ). Other different combinations of two kinds of markers are also determined to have effective prognostic ability in tumors ( 51 , 52 ). Some of these prognostic scores like GPS and CONUT are also researched in patients with GBM, and the results are consistent with those of previous studies ( 25 , 53 ).…”

Section: Discussionmentioning

confidence: 99%

Preoperative Naples prognostic score is a reliable prognostic indicator for newly diagnosed glioblastoma patients

Yang

Yuan

et al. 2022

Front. Oncol.

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BackgroundGlioblastoma (GBM) accounts for approximately 80% of malignant gliomas and is characterized by considerable cellularity and mitotic activity, vascular proliferation, and necrosis. Naples prognostic score (NPS), based on inflammatory markers and nutritional status, has a prognostic ability in various cancers. In the current study, we aim to explore the prognostic value of operative NPS in GBM patients and compare the prognostic ability between NPS and controlling nutritional status (CONUT).Materials and methodsThe retrospective analysis was carried out on consecutive newly diagnosed GBM patients who had underwent tumor resection at West China Hospital from February 2016 to March 2019. All statistical analyses were conducted using SPSS software and R software.ResultsA total of 276 newly diagnosed GBM patients were enrolled in the current study. Overall survival (OS) (p < 0.001) and tumor location (p = 0.007) were significantly related to NPS. Serum albumin concentrate, cholesterol concentrate, neutrophil-to-lymphocyte ratio, lymphocyte ratio, and CONUT score were all significantly associated with NPS (p < 0.001). The Kaplan–Meier curve indicated that NPS (log-rank test, p < 0.001) and CONUT score (log-rank test, p = 0.023) were significantly associated with OS. Multivariate Cox regression revealed that both NPS and CONUT score served as independent prognostic indicators. The prognostic model with NPS had the strongest prognostic capability and best model-fitting.ConclusionIn the current study, NPS is found as an independent prognostic indicator for patients with newly diagnosed GBM, and the prognostic ability of NPS is superior to CONUT score.

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Prognostic efficacy of preoperative mGPS, SIS and LCS in patients with gastric cancer

Cited by 17 publications

References 40 publications

Can the systemic inflammation score be used to predict prognosis in gastric cancer patients undergoing surgery? A systematic review and meta-analysis

Can the systemic inflammation score be used to predict prognosis in gastric cancer patients undergoing surgery? A systematic review and meta-analysis

A potential novel biomarker in predicting lymph node metastasis of gastric signet ring cell carcinoma: A derived monocyte to lymphocyte ratio

Preoperative Naples prognostic score is a reliable prognostic indicator for newly diagnosed glioblastoma patients

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