One remaining technological bottleneck to develop industrial Fuel Cell (FC) applications resides in the system limited useful lifetime. Consequently, it is important to develop failure diagnostic and prognostic tools enabling the optimization of the FC. Among all the existing prognostics approaches, datamining methods such as artificial neural networks aim at estimating the process' behavior without huge knowledge about the underlying physical phenomena. Nevertheless, this kind of approach needs huge learning dataset. Also, the deployment of such an approach can be long (trial and error method), which represents a real problem for industrial applications where realtime complying algorithms must be developed. According to this, the aim of this paper is to study the application of a reservoir computing tool (the Echo State Network) as a prognostics system enabling the estimation of the Remaining Useful Life of a Proton Exchange Membrane Fuel Cell. Developments emphasize on the prediction of the mean voltage cells of a degrading FC. Accuracy and time consumption of the approach are studied, as well as sensitivity of several parameters of the ESN. Results appear to be very promising.