Prognostic evaluation of soluble CD40L in acute myocardial infarction: is not fancy, is science!

Napoleão, Patrícia; Carmo, Miguel Mota; Pinheiro, Teresa

doi:10.21037/atm.2017.01.58

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…Previous studies showed that CD40L could bind to its receptors on macrophage surface and promote the secretion of inflammatory factors during infection, atherosclerosis, and myocardial infarction. [19][20][21] In this study, the sCD40L level was significantly higher in UA patients than that of healthy control. This may be caused by platelet activation.…”

Section: Discussionsupporting

confidence: 43%

Serum CD40L, ST2, IL-6, and CRP serving as biomarkers for acute coronary syndrome

et al. 2022

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To analyze the diagnostic value of CD40 ligand (CD40L), soluble growth stimulating expression gene 2 protein (ST2), interleukin-6 (IL-6), and C-reactive protein (CRP) are used in patients with acute coronary syndrome (ACS). Serum samples were collected from 259 ACS patients admitted to our hospital. Additionally, 119 healthy individuals who received physical examination in the hospital at the same time period were included as normal control. The levels of CD40L, ST2, IL-6, and CRP in 259 patients with ACS and 119 healthy subjects were detected by ELISA. The levels of CD40L, ST2, IL-6, and CRP were significantly increased in unstable angina (UA) patients, while ST2, CRP, and IL-6 were significantly elevated in acute myocardial infarction (AMI) patients. Pearson correlation analysis showed that ST2 was also closely related to CRP in ACS patients, while ST2 was positively correlated with creatine kinase (CK), creatine kinase isoenzyme (CK-MB), and troponin I (cTnI) in AMI patients. The levels of glucose (GLU) and low-density lipoprotein cholesterol (LDL-c) were significantly decreased, while the levels of high-density lipoprotein cholesterol (HDL-c) were significantly increased in AMI patients treated with stent implantation. Furthermore, the level of serum CD40 L was significantly elevated in coronary heart disease (CHD) patients treated with stent implantation, while the levels of ST2 and IL-6 in AMI patients treated with the stent implantation decreased significantly. The levels of inflammatory factors significantly changed in patients with ACS. These inflammatory factors may involve in the pathological progression of ACS and can be used as diagnostic indexes for ACS.

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Section: Discussionsupporting

confidence: 43%

Serum CD40L, ST2, IL-6, and CRP serving as biomarkers for acute coronary syndrome

et al. 2022

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“…Napoleao et al showed that the concentration of sCD40L increased over time after the onset of myocardial infarction, associated with endothelial NOS (eNOS) polymorphism and Vascular Endothelial Growth Factor (VEGF) concentration (109). These results indicate that sCD40L should not only be considered involved in haemostasis and inflammation, but also plays an important role in vascular and endothelial dysfunction (109)(110)(111)(112)(113). Although most studies confirm the important role of the various platelet sCD40L/CD40 axes in thrombo-inflammation, further studies are needed to describe their complete signalling pathways and the precise molecular effects they have on platelet functions.…”

Section: Involvement Of the Cd40l/cd40 Axis In Platelet Functions In ...mentioning

confidence: 99%

Platelets as Key Factors in Inflammation: Focus on CD40L/CD40

et al. 2022

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Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary megakaryocytes. Activated platelets adhere to the damaged endothelium by means of glycoproteins on their surface, forming the platelet plug. Activated platelets can also secrete the contents of their granules, notably the growth factors contained in the α-granules, which are involved in platelet aggregation and maintain endothelial activation, but also contribute to vascular repair and angiogenesis. Platelets also have a major inflammatory and immune function in antibacterial defence, essentially through their Toll-like Receptors (TLRs) and Sialic acid-binding immunoglobulin-type lectin (SIGLEC). Platelet activation also contributes to the extensive release of anti- or pro-inflammatory mediators such as IL-1β, RANTES (Regulated on Activation, Normal T Expressed and Secreted) or CD154, also known as the CD40-ligand. Platelets are involved in the direct activation of immune cells, polynuclear neutrophils (PNNs) and dendritic cells via the CD40L/CD40 complex. As a general rule, all of the studies presented in this review show that platelets are capable of covering most of the stages of inflammation, primarily through the CD40L/CD40 interaction, thus confirming their own role in this pathophysiological condition.

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“…e IL-6 receptor antagonist could improve the inflammatory response and the percutaneous coronary intervention-(PCI-) treated cTn release in NSTEMI, and this improvement is independent of the inhibition of the endothelial cell activation [79]. [80], and a study has shown that it mediates the interaction of platelets and neutrophils [81]. In addition, another study confirms that sCD40L plays a role in the vascular and endothelial dysfunction seen in AMI progression [82].…”

Section: Interleukin-6 (Il-6)mentioning

confidence: 96%

The Biomarkers for Acute Myocardial Infarction and Heart Failure

Wang

Zhang

et al. 2020

BioMed Research International

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The use of a large number of cardiovascular biomarkers, meant to complement the use of the electrocardiogram, echocardiography cardiac imaging, and clinical symptom assessment, has become a routine in clinical diagnosis, differential diagnosis, risk stratification, and prognosis and guides the management of patients with suspected cardiovascular diseases. There is a broad consensus that cardiac troponin and natriuretic peptides are the preferred biomarkers in clinical practice for the diagnosis of the acute coronary syndrome and heart failure, respectively, while the roles and possible clinical applications of several other potential biomarkers are still under study. This review mainly focuses on the recent studies of the roles and clinical applications of troponin and natriuretic peptides, which seem to be the best-validated markers in distinguishing and predicting the future cardiac events of patients with suspected cardiovascular diseases. Additionally, the review briefly discusses some of the large number of potential markers that may play a more prominent role in the future.

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Prognostic evaluation of soluble CD40L in acute myocardial infarction: is not fancy, is science!

Cited by 6 publications

References 13 publications

Serum CD40L, ST2, IL-6, and CRP serving as biomarkers for acute coronary syndrome

Serum CD40L, ST2, IL-6, and CRP serving as biomarkers for acute coronary syndrome

Platelets as Key Factors in Inflammation: Focus on CD40L/CD40

The Biomarkers for Acute Myocardial Infarction and Heart Failure

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