Prognostic factors affecting outcome of multifocal or multicentric glioblastoma: A scoping review

Das, Saikat; Mishra, Rakesh; Agrawal, Amit

doi:10.25259/jnrp_41_2022

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…However, those results require large validating multicenter clinical studies [153]. While multifocal HGGs and their infratentorial recurrences (ITR) negatively influence the prognosis of HGG patients [154,155], the socioeconomic status (SES) has been indicated as a positive prognostic factor. Here again, large and well-designed studies are necessary [156].…”

Section: Modelling the Prognosis Of Hggmentioning

confidence: 99%

Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated

Frosina

2024

Cancers

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The first half of 2022 saw the publication of several major research advances in image-based models and artificial intelligence applications to optimize treatment strategies for high-grade gliomas, the deadliest brain tumors. We review them and discuss the barriers that delay their entry into clinical practice; particularly, the small sample size and the heterogeneity of the study designs and methodologies used. We will also write about the poor and late palliation that patients suffering from high-grade glioma can count on at the end of life, as well as the current legislative instruments, with particular reference to Italy. We suggest measures to accelerate the gradual progress in image-based models and end of life care for patients with high-grade glioma.

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Section: Modelling the Prognosis Of Hggmentioning

confidence: 99%

Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated

Frosina

2024

Cancers

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“…█ INTRODUCTION G lioblastoma (GBM) stands as the most prevalent primary malignant tumor within the central nervous system (CNS) and bears an unfavorable prognosis despite contemporary treatments (11). Typically, GBMs manifest as solitary lesions; nevertheless, approximately 0.5 to 20% of all GBMs emerge as multiple lesions (M-GBM) (2).…”

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confidence: 99%

Comparative analysis of idh wild-type multifocal and unifocal glioblastomas: prognostic factors and survival outcomes in focus

Habiboglu,

Kayali,

Saricanbaz

et al. 2023

Turkish Neurosurgery

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AIM:To compare the overall survival (OS), progression-free survival (PFS), and the impact of prognostic markers in unifocal and multifocal IDH wild-type glioblastomas (GBMs). MATERIAL and METHODS:This retrospective single-institutional study involved 177 GBM patients diagnosed between 2015 and 2022. Patients with confirmed IDH wild-type GBM were selected to assess the impact of lesion focalities on prognosis. Surgical procedures included gross total resection (GTR), subtotal resection (STR) or biopsy. Radiation therapy (RT) employed the intensitymodulated (IM)RT technique, combined with concurrent temozolomide (TMZ) treatment. Survival analyses and prognostic factors were performed accordingly. RESULTS:We examined 101 IDH wild-type glioblastoma patients, of whom 78 had unifocal and 23 had multifocal tumors. The median patient age was 60 years, comprising 37% females and 63% males. Surgical approaches included GTR (13%), STR (53%), and biopsy (34%). Positive p53 expression was seen in 65 patients. All patients received TMZ with RT. Adjuvant therapy referral was arranged for 68 patients. Progression occurred in 49% (38 unifocal, 11 multifocal cases). PFS analysis showed no significant difference between unifocal and multifocal patients. OS analysis also showed no significant difference. Univariate analysis revealed PFS factors: focalization, p53 expression, hypofractionated RT. For OS, adjuvant TMZ usage was influential. Extent of resection impacted OS-STR had 3.47-fold higher risk than GTR. CONCLUSION:This study sheds light on the management of multifocal glioblastoma, providing insights into treatment strategies and survival outcomes. Despite challenges, optimal management approaches are crucial for improving patient prognosis and quality of life.

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Patterns of care and survival in patients with multifocal glioblastoma: A Danish cohort study

Trip,

Hedegaard Dahlrot,

Aaquist Haslund

et al. 2024

Neuro-Oncology Practice

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Background This Danish cohort study aims to (1) compare patterns of care (POC) and survival of patients with multifocal glioblastoma (mGBM) to those with unifocal glioblastoma (uGBM), and (2) explore the association of patient-related factors with treatment assignment and prognosis, respectively, in the subgroup of mGBM patients. Methods Data on all adults with newly diagnosed, pathology-confirmed GBM between 2015-2019 was extracted from the Danish Neuro-Oncology Registry. To compare POC and survival of mGBM to uGBM, we applied multivariable logistic and Cox regression analysis, respectively. To analyze the association of patient-related factors with treatment assignment and prognosis, we established multivariable logistic and Cox regression models, respectively. Results In this cohort of 1343 patients, 231 had mGBM. Of those, 42% underwent tumor resection and 41% were assigned to long-course chemoradiotherapy. Compared to uGBM, mGBM patients less often underwent a partial (OR 0.4, 95%CI 0.2-0.6), near total (OR 0.1, 95%CI 0.07-0.2), and complete resection (OR 0.1, 95%CI 0.07-0.2) vs biopsy. mGBM patients were furthermore less often assigned to long-course chemoradiotherapy (OR 0.6, 95%CI 0.4-0.97). Median overall survival was 7.0 (95% CI 5.7-8.3) months for mGBM patients, and multifocality was an independent poor prognostic factor for survival (HR 1.3, 95%CI 1.1-1.5). In mGBM patients, initial performance, O[6]-methylguanine-DNA methyltransferase (MGMT) promotor methylation status, and extent of resection were significantly associated with survival. Conclusions Patients with mGBM were treated with an overall less intensive approach. Multifocality was a poor prognostic factor for survival with a moderate effect. Prognostic factors for patients with mGBM were identified.

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Prognostic factors affecting outcome of multifocal or multicentric glioblastoma: A scoping review

Cited by 3 publications

References 34 publications

Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated

Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated

Comparative analysis of idh wild-type multifocal and unifocal glioblastomas: prognostic factors and survival outcomes in focus

Patterns of care and survival in patients with multifocal glioblastoma: A Danish cohort study

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