Prognostic factors affecting periodontal regenerative therapy using recombinant human fibroblast growth factor-2: A 3-year cohort study

Mikami, Risako; Sudo, Tatsuhiko; Fukuba, Shunsuke; Takeda, Kohei; Matsuura, Takanori; Kariya, Tomoaki; Takeuchi, Shunsuke; Ochiai, Akane; Kawamoto, Sakurako; Toyoshima, Keita; Mizutani, Koji; Arakawa, Shin’ichi; Aoki, Akira; Iwata, Takanori

doi:10.1016/j.reth.2022.07.006

Cited by 11 publications

(13 citation statements)

References 36 publications

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“…However, the decrease of IBD was considered no statistically significant between two groups. Reduction of periodontal pocket depth reached stable 6 months after surgery, but the gradual recovery of radiographic bone height continued for almost 1–3 years [ 31 ]. Therefore, longer follow-up is needed to find out the difference in the bone regeneration.…”

Section: Discussionmentioning

confidence: 99%

A novel periodontal endoscopy-aided non-incisional periodontal regeneration technique in the treatment of intrabony defects: a retrospective cohort study

Shi,

Wang,

Yang

et al. 2023

BMC Oral Health

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Background Gingival recession and post-operation discomfort are still a problem for patients receiving the periodontal regeneration surgery for intra-bony defects. To further reduce the trauma and the post-operation gingival recession, a novel periodontal endoscopy-aided non-incisional regeneration technique (NIT) was proposed in the treatment of intra-bony defects. Methods Retrospective analysis of 21 subjects treated with NIT and 21 subjects with periodontal endoscopy-aided scaling and root planing (PSRP) at baseline and 1-year evaluation was conducted. After removing the subgingival calculus and granulation tissue, bone grafting materials were placed into intrabony defects with the assistance of a gingival retractor in the NIT group. Probing depth (PD), gingival recession (GR), clinical attachment level (CAL), as well as the distance between bone crest (BC) level and base of the defect (BD) (intrabony defect depth, IBD) were evaluated at baseline and 1 year after treatment. Results At 1-year follow-up, the value of CAL, PD and IBD were statistically significant different compared with baseline in both two groups (p<0.001). CAL gain (p = 0.012) and PD reduction (p = 0.004) was greater in the NIT than PSRP. However, no difference in the IBD reduction was found between the NIT group and PSRP. Better CAL gain and PD reduction was achieved in the 1-year term in the NIT when compared with PSRP. Conclusion NIT have resulted in significant gains in both clinical and radiographic parameters. NIT might be utilized as an alternative of the surgical treatment for periodontal intrabony defects. Trial registration This clinical trial registration was registered retrospectively (August 3, 2023) and the number is ChiCTR2300074317.

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Section: Discussionmentioning

confidence: 99%

A novel periodontal endoscopy-aided non-incisional periodontal regeneration technique in the treatment of intrabony defects: a retrospective cohort study

Shi,

Wang,

Yang

et al. 2023

BMC Oral Health

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“… 24 In contrast, growth factors such as FGF-2, PDGF, and bone morphogenetic protein-2, in conjunction with various biomaterials, have also demonstrated improved clinical outcomes. 25 , 26 , 27 , 28…”

Section: Clinical Advancementsmentioning

confidence: 99%

Advances in Regenerative Dentistry Approaches: An Update

Thalakiriyawa

Dissanayaka

2024

International Dental Journal

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“…Therefore, root exposure, cosmetic issue, increased caries risk, and recurrence risk of periodontitis are maintained [ 6 ]. Several periodontal regeneration therapies, such as making space for mesenchymal cells to migrate by guided tissue regeneration (GTR) and topical application of Emdogain gel or recombinant FGF-2 gel, have been clinically applied [ 7 , 8 ]. These biocompatible treatments partially achieve physiological periodontal tissue regeneration of vertical alveolar bone defects and defects limited to the furcation area.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Activation of YAP/TAZ by Targeting LATS1/2 Enhances Periodontal Tissue Regeneration in a Murine Model

Satô

Suzuki

Yuan

et al. 2023

IJMS

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Due to their multi-differentiation potential, periodontal ligament fibroblasts (PDLF) play pivotal roles in periodontal tissue regeneration in vivo. Several in vitro studies have suggested that PDLFs can transmit mechanical stress into favorable basic cellular functions. However, the application of mechanical force for periodontal regeneration therapy is not expected to exhibit an effective prognosis since mechanical forces, such as traumatic occlusion, also exacerbate periodontal tissue degeneration and loss. Herein, we established a standardized murine periodontal regeneration model and evaluated the regeneration process associated with cementum remodeling. By administering a kinase inhibitor of YAP/TAZ suppressor molecules, such as large tumor suppressor homolog 1/2 (LATS1/2), we found that the activation of YAP/TAZ, a key downstream effector of mechanical signals, accelerated periodontal tissue regeneration due to the activation of PDLF cell proliferation. Mechanistically, among six kinds of MAP4Ks previously reported as upstream kinases that suppressed YAP/TAZ transcriptional activity through LATS1/2 in various types of cells, MAP4K4 was identified as the predominant MAP4K in PDLF and contributed to cell proliferation and differentiation depending on its kinase activity. Ultimately, pharmacological activation of YAP/TAZ by inhibiting upstream inhibitory kinase in PDLFs is a valuable strategy for improving the clinical outcomes of periodontal regeneration therapies.

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Prognostic factors affecting periodontal regenerative therapy using recombinant human fibroblast growth factor-2: A 3-year cohort study

Cited by 11 publications

References 36 publications

A novel periodontal endoscopy-aided non-incisional periodontal regeneration technique in the treatment of intrabony defects: a retrospective cohort study

A novel periodontal endoscopy-aided non-incisional periodontal regeneration technique in the treatment of intrabony defects: a retrospective cohort study

Advances in Regenerative Dentistry Approaches: An Update

Pharmacological Activation of YAP/TAZ by Targeting LATS1/2 Enhances Periodontal Tissue Regeneration in a Murine Model

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