Prognostic factors and imaging patterns of recurrent pulmonary nodules after thoracotomy in children with osteosarcoma

McCarville, M. Beth; Kaste, C D O Sue; Ccra, Alvida M. Cain; Goloubeva, Olga; Rao, Bhaskar N.; Pratt, Charles B.

doi:10.1002/1097-0142(20010315)91:6<1170::aid-cncr1114>3.0.co;2-b

Cited by 54 publications

(38 citation statements)

References 22 publications

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“…Indications included metastatic disease (nZ15); diagnostic biopsy in cases of diffuse pulmonary infiltration in patients with leukemia (nZ2); diagnostic biopsy in patients with an immune defect (nZ3); malformation (nZ4); infection (nZ1); and trauma (nZ2). Multiple resections (up to 10) were performed in four children. Six children underwent atypical resections as a second or third surgical procedure.…”

Section: Surgical Proceduresmentioning

confidence: 98%

“…An aggressive approach to the treatment of pulmonary metastases is justified when the criteria for establishing a curative intention are met [10,16]. In our series one child with pulmonary metastases of a primary osteosarcoma underwent 10 atypical resections and has remained disease free during the subsequent follow-up period.…”

Section: Indicationmentioning

confidence: 99%

“…Second thoracotomies may also be justified in patients with recurrent disease. Snyder et al [11] McCarville et al [10] report good results in children who had undergone five to six thoracotomies for management of pulmonary metastases of osteosarcoma. Four of five children with an immune defect underwent a thoracic surgical procedure for purely diagnostic reasons.…”

Section: Indicationmentioning

confidence: 99%

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Thoracic surgery in children

Kanngiesser

Liewald

Halter

et al. 2005

European Journal of Cardio-Thoracic Surgery

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Thoracic surgical procedures in children with underlying benign disease are associated with a good prognosis and high quality of life scores. Surgical treatment of pulmonary metastases is a feasible component of the overall oncologic therapy concept and can offer the only opportunity for curation for a selected group of patients. Because of high postoperative mortality, however, the indication for diagnostic thoracotomies in children with immunodeficiencies and poor general health should be weighed critically.

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Section: Surgical Proceduresmentioning

confidence: 98%

Section: Indicationmentioning

confidence: 99%

Section: Indicationmentioning

confidence: 99%

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Thoracic surgery in children

Kanngiesser

Liewald

Halter

et al. 2005

European Journal of Cardio-Thoracic Surgery

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“…In fact, in the aforementioned series with 45% benign nodules, nonmalignant lesions accounted for two of nine (22%) cases of osteosarcoma versus 11 of 20 (55%) of other malignancies [3]. Moreover, osteosarcoma metastases have no specific radiological features [4] and CT imaging cannot distinguish reliably between benign and metastatic pulmonary disease, making preoperative selection very difficult [5].…”

Section: Discussionmentioning

confidence: 99%

Optimizing the surgical management of lung nodules in children with osteosarcoma: Thoracoscopy for biopsies, thoracotomy for resections

Castagnetti

Gentet

2004

Surg Endosc

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“…After surgical resection, a chemotherapeutical approach to treat remaining micrometastatic spreading is recommended [46]. Various studies have demonstrated that repeated pulmonary resections enable controlling the disease for an extended period [47]. With the localized surgical and the systemic chemotherapeutical approach completing one another, long-term survival is encouraging, with a 5-year survival rate of about 30% [48].…”

Section: Osteogenic Sarcomasmentioning

confidence: 96%

Pulmonary metastasectomy

et al. 2011

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Background: The major obstacle in curing cancer is the limited ability to prevent and treat metastatic disease. Pulmonary metastasectomy is now a standard treatment option in carefully selected cases. With the lung being frequently the only site of metastasis, a complete resection of all tumor masses poses a potentially curative treatment option.Methods: This review article gives an outline of the basics of pulmonary metastasectomy and reviews the latest research in this field.Results and conclusions: Technical advances in thoracic surgery during the past decades made pulmonary metastasectomy a safe procedure with a low morbidity. However, surgical resection must be embedded in an individualized oncological concept.The beginnings of pulmonary metastasectomy can be traced back to the 19th century. The first case of a resection of pulmonary metastases was reported in 1882. Josef Weinlechner, a Viennese pediatric surgeon, accidentally discovered and resected two metastatic nodules in the lung when removing a large sarcoma of the thoracic wall [1]. Unfortunately, this first patient died the day after surgery from shock. Throughout the following decades, single case reports of pulmonary metastasectomy have been described in the literature. In most cases, the resection of pulmonary nodules led to long-term survival. As open chest surgery in those times was itself a life-threatening intervention, beneficial effects of metastasectomy were often restrained by the high mortality and morbidity of the surgical procedure. Since these early days of pulmonary metastasectomy, many advances have been made in surgical techniques and perioperative patient care. Consequently, pulmonary metastasectomy has developed into one of the major surgical procedures in thoracic surgery [2].

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Prognostic factors and imaging patterns of recurrent pulmonary nodules after thoracotomy in children with osteosarcoma

Cited by 54 publications

References 22 publications

Thoracic surgery in children

Thoracic surgery in children

Optimizing the surgical management of lung nodules in children with osteosarcoma: Thoracoscopy for biopsies, thoracotomy for resections

Pulmonary metastasectomy

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