Prognostic factors and impact of CMV reactivation on acute myeloid leukemia patients after HLA-matched myeloablative allogeneic stem cell transplantation in a high CMV prevalence country

Chanswangphuwana, Chantiya; Wudhikarn, Kitsada; Watanaboonyongcharoen, Phandee; Kansuwan, Patsita; Sukperm, Autcharaporn; Bunworasate, Udomsak

doi:10.1016/j.htct.2022.01.006

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…The existence of IgG, which was evident in the prior infection, does not stop reinfection or reactivation but may decrease the degree of pathogenicity. While IgM immunoglobulin, which forms right after infection and vanishes within a brief (16)(17)(18)(19)(20) weeks, was thought to be a sign of recent or acute infection [17] According to the current study, 96.3% of women who had abortions were seropositive for HCMV. Numerous investigations were conducted in Iraq to determine the seropositivity of HCMV in women who had abortions, in a study conducted in Baquba showed the seropositivity of HCMV was 16.8% [18], while in Wasit Province had an HCMV seropositivity of 60.2%, Baghdad had a seropositivity of 10%, and Sulimania County had a seropositivity of 9.18% [19].…”

Section: Immunological Detection Of Cytomegalovirus By Elisamentioning

confidence: 59%

“…In a previous study, the value of induced abortions in low-income women was poor; the majority had them at health facilities, but 4% had them at home in communities with medical colleges nearby, while no difficulties occurred; there were also misunderstandings and a lack of information [45]. Raza et al [46] found that the age group (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) years had the greatest rate of women who had abortions in Kirkuk, Iraq.…”

Section: Relation Of Abortions Number With Socio-demographic Characte...mentioning

confidence: 99%

“…Urine testing should be done since saliva samples might yield false-positive findings when used to diagnose congenital CMV. After delivery, CMV-DNA might be found in urine samples for up to two years [16].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation The Sero-Prevalence of Cytomegalovirus Infection among Abortion Women in Baqubah city

Hussain Kalaf,

Jaafar Jameel

2023

acad. sci. j.

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Cytomegalovirus (CMV) consider one of the opportunistic viruses, with a worldwide distribution, that can infect humans at any stage of life. It is a major cause of prenatal and perinatal infections and may lead to important complications in pregnancy. This study aims to assess the serum anti-CMV antibody (IgG and IgM) levels in blood of women who suffered abortion and correlation of aborted women with socio-demographic characteristics such as age, living, academic achievement, number of abortion, and fetus age This research was performed between November 2021 and January 2022 on 80 women suffering from abortion and 20 healthy control women in Al-Batool Teaching Hospital in Baqubah city. ELISA test results showed that the abortion women shown highest percentage of seropositive to CMV for IgG (96.3%) and (40%) IgM with a significant difference as compared to the control group (P < 0.05). Anti-CMV IgG and IgM seropositivity were higher in younger women (20-30 years).The current study found that the age group 21-30 years had the highest rate of abortions, with significant differences (P < 0.05). The findings of this study also show that uneducated women, and the women living in rural areas have a higher rate of abortion (58.8% and 72.5%) respectively with significant difference (P < 0.05). Furthermore, the current study found a

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Section: Immunological Detection Of Cytomegalovirus By Elisamentioning

confidence: 59%

Section: Relation Of Abortions Number With Socio-demographic Characte...mentioning

confidence: 99%

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Evaluation The Sero-Prevalence of Cytomegalovirus Infection among Abortion Women in Baqubah city

Hussain Kalaf,

Jaafar Jameel

2023

acad. sci. j.

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“…In our practical experience, 65% of our patients with acute GVHD and a low qPCR showed a rapid increase in the viral load, when on steroid therapy. As a consequence, the course of CMV infection can be rapidly progressive and ultimately fatal [22][23][24][25]. However, the exact threshold for treatment is still an area of controversy, different thresholds have been used and vary according to the severity of immunosuppression and different centers [9,[26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Oral Versus Intravenous Anti-CMV Preemptive Strategies in Allogeneic Stem Cell Transplant Patients with CMV Reactivation: Experience from the National Center of Bone Marrow Transplantation, Tunis, Tunisia

Kanoun,

Ben Abdeljelil,

Hsasna

et al. 2023

OBM Transplant

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Cytomegalovirus (CMV) infection is a common and severe complication following allogeneic stem cell transplantation (ASCT) and requires effective preemptive antiviral therapy. Both oral and intravenous (IV) antiviral agents effectively reduce CMV viral load and achieve viral clearance. Studies comparing oral and IV anti-CMV preemptive treatment in ASCT patients with CMV reactivation showed a potential difference in treatment response and safety profiles between the two administration routes. We retrospectively compared the efficacy and safety of oral with intravenous (IV) anti-CMV preemptive therapy in ASCT recipients with CMV reactivation. A descriptive retrospective study included patients who received their first ASCT between January 2018 and June 2022. The monitoring oral load was assessed weekly using a quantitative polymerase chain reaction in plasma. Fifty-five patients developing 72 CMV reactivations were included. The median age was 29 years (range, 6-50). The main underlying diseases were acute leukemia and aplastic anemia. Before ASCT, 96% of patients were at high risk of CMV reactivation. CMV reactivations were observed at a median of 43 days (range, 16-270) post-ASCT. The median viral load at CMV reactivation was 248 copies/mL (range, 150-4800). The first-line preemptive treatment was oral in 51 (71%) of the episodes (Valganciclovir, n = 40; Leflunomide, n = 11) and IV in 21 (29%) of the episodes (Foscarnet, n = 16; Ganciclovir, n = 5). Response to first-line therapy was not statistically significant between the two groups (74% vs 76%, p = 0.88). Thirteen (25%) and 5 (24%) episodes needed second or subsequent-line therapy in the oral and IV groups, respectively. The hematological toxicity was significantly higher in the oral group (61% vs 29%, p = 0.01). The mean duration of hospital stay per patient in the oral and IV groups was 7 days and 49 days (p < 10<sup>-3</sup>), respectively. More non-CMV documented infections were observed in the IV group (38% vs 4%, p = 0.001). After a median follow-up of 18 months (range, 2-55), the 2-year-overall survival, event-free survival and cumulative incidence of non-relapse mortality were 85%, 75% and 6%, respectively. Our results showed that the oral preemptive therapy for CMV reactivations after ASCT was as effective as IV formulations and needed less hospital stay time. However, it is associated with more hematological toxicity.

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Early Allogeneic Transplantation Favorably Influences the Outcome of Pediatric Acute Myeloid Leukemia—A Retrospective Study in a Single Center Over 2 Decades

Lo,

Wang,

Jaing

et al. 2024

Transplantation Proceedings

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Prognostic factors and impact of CMV reactivation on acute myeloid leukemia patients after HLA-matched myeloablative allogeneic stem cell transplantation in a high CMV prevalence country

Cited by 4 publications

References 24 publications

Evaluation The Sero-Prevalence of Cytomegalovirus Infection among Abortion Women in Baqubah city

Evaluation The Sero-Prevalence of Cytomegalovirus Infection among Abortion Women in Baqubah city

Oral Versus Intravenous Anti-CMV Preemptive Strategies in Allogeneic Stem Cell Transplant Patients with CMV Reactivation: Experience from the National Center of Bone Marrow Transplantation, Tunis, Tunisia

Early Allogeneic Transplantation Favorably Influences the Outcome of Pediatric Acute Myeloid Leukemia—A Retrospective Study in a Single Center Over 2 Decades

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