Prognostic Factors and Outcomes of Patients After Liver Retransplantation

Masior, Łukasz; Grąt, Michał; Krasnodębski, Maciej; Patkowski, Waldemar; Figiel, Wojciech; Bik, Emil; Krawczyk, Marek

doi:10.1016/j.transproceed.2016.01.055

Cited by 13 publications

(12 citation statements)

References 22 publications

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“…be a strong predictor of survival after re-LT. (24) With some variation in the proposed cutoff points, reports indicate that the higher the MELD/PELD scores, the worse the post-re-LT outcome, and they show a very low survival rate when the PELD/MELD scores are 25-30 or higher. (21,25) Similarly, a good performance of the PELD/MELD scores for the prediction of post-eRe-LT survival was observed in the present study. An era effect on post-LT results is consistently reported in most of the large series from centers that have performed LTs over the past 25-30 years.…”

Section: Original Articlesupporting

confidence: 86%

“…Different studies have shown that, in the context of graft failure and need for re‐LT, the MELD score may be a strong predictor of survival after re‐LT . With some variation in the proposed cutoff points, reports indicate that the higher the MELD/PELD scores, the worse the post–re‐LT outcome, and they show a very low survival rate when the PELD/MELD scores are 25‐30 or higher . Similarly, a good performance of the PELD/MELD scores for the prediction of post–eRe‐LT survival was observed in the present study.…”

Section: Discussionmentioning

confidence: 96%

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Prognostic Factors in Pediatric Early Liver Retransplantation

Reyes¹,

Halac²,

Aredes³

et al. 2020

Liver Transpl

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The most common indications for early liver retransplantation (eRe‐LT) are vascular complications and primary nonfunction (PNF). These patients are usually in a critical clinical condition that can affect their chances of survival. In fact, the survival of these patients is usually lower compared with the patients undergoing a first transplant. To the best of our knowledge, no specific series of pediatric patients undergoing eRe‐LT has been published to date. Therefore, the aim of this study is to report the results of eRe‐LT and to analyze factors potentially related to success or failure. Our work is of a retrospective cohort study of patients who underwent eRe‐LT at the Juan P. Garrahan Pediatric Hospital of Buenos Aires, Argentina, between May 1995 and December 2018 (n = 60). Re‐LT was considered early when performed ≤30 days after the previous LT. A total of 40 (66.7%) patients were enrolled due to vascular causes and 20 (33.3%) were enrolled because of PNF. Of all the relisted patients, 36 underwent eRe‐LT, 14 died on the waiting list, and 10 recovered without eRe‐LT. A total of 23 (63.9%) patients died after eRe‐LT, most of them due to infection‐related complications. Survival rates at 1 and 5 years were 42.4% and 33.9%, respectively. On univariate logistic regression analysis, Pediatric End‐Stage Liver Disease (PELD)/Model for End‐Stage Liver Disease (MELD) scores, transplant era, and advanced life support at eRe‐LT were found to be related to 60‐day mortality. However, on multivariate analysis, era (odds ratio [OR], 9.3; 95% confidence interval [CI], 1.19‐72.35; P = 0.033) and PELD/MELD scores (OR, 1.07; 95% CI, 1‐1.14; P = 0.036) were significantly associated with 60‐day patient mortality. This study found that the level of acuity before retransplant, measured by the requirement of advanced life support and the PELD/MELD score at eRe‐LT, was significantly associated with the chances of post–eRe‐LT patient survival.

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Section: Original Articlesupporting

confidence: 86%

Section: Discussionmentioning

confidence: 96%

Prognostic Factors in Pediatric Early Liver Retransplantation

Reyes¹,

Halac²,

Aredes³

et al. 2020

Liver Transpl

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“…Andorno et al [20] reported that the difference in overall patient survival for patients who received re-transplantation or not was not significant. Considering the complications, re-transplantation may cause hepatic artery thrombosis and primary function failure, thus leading to irreversible hepatic graft failure [21]. Furthermore, how to ensure the life quality of patients and delay the growth rate of tumour after LT is of great significance.…”

Section: Discussionmentioning

confidence: 99%

Long-term outcome of percutaneous radiofrequency ablation in recurrent hepatocellular carcinoma after liver transplantation

Yang

Zhang

et al. 2017

International Journal of Hyperthermia

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“…After the launch of cyclosporine in the 1980 s, 1-year survival rates after LT rose to greater than. Further, in centers with greater experience, more than 70 % of liver transplant recipients survived 5 years [4]. Nevertheless, despite improvements in technique and medications, a substantial number of patients still develop graft failure after LT, and 10 -20 % of patients still require retransplantation [5].…”

Section: Introductionmentioning

confidence: 99%