Prognostic Factors and Surgical Indications of Pulmonary Epithelioid Hemangioendothelioma: A Review of the Literature

Bagan, Patrick; Hassan, Mohammed; Barthes, F. Le Pimpec; Peyrard, Séverine; Souilamas, Rédha; Danel, Claire; Riquet, Marc

doi:10.1016/j.athoracsur.2006.06.068

Cited by 167 publications

(180 citation statements)

References 28 publications

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“…Several studies have shown that a partial remission could be achieved with carboplatin, paclitaxel, and bevacizumab, a monoclonal antibody that blocks human vascular endothelial growth factor-A [11]. A partial response of the pulmonary lesions was obtained with interferon α-2a, probably due to its antiangiogenic activity [12]. Follow-up chest CT scan after chemotherapy showed no significant change in the tumor size and number.…”

Section: Discussionmentioning

confidence: 97%

“…Several studies reported that lack of these symptoms was associated with a lower risk for cancer progression [5,12].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported various prognostic factors. Some prognostic factors of PEH such as hemorrhagic symptoms (pleural effusion, alveolar hemorrhage, anemia, and hemoptysis) can reveal markers of vascular aggressiveness [5,12].…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary epithelioid hemangioendothelioma misconceived as pulmonary metastasis of other malignancies

Noh

Lee

Sohn

et al. 2016

Yeungnam Univ J Med

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Pulmonary epithelioid hemangioendothelioma (PEH) is a rare, low-to-intermediate malignant tumor of endothelial origin. Computed tomography (CT) findings of PEH demonstrate multiple small bilateral nodules; however, to the best of our knowledge, there were no reports on PEH coexisting with other malignancies. Here, we reported on a case involving PEH in a patient with colon cancer and breast cancer which was misconceived as pulmonary meta-stasis. A 63-year-old woman who suffered from constipation for 2 weeks visited our hospital. Colonoscopy showed a large mass with obstruction on hepatic flexure. The histological diagnosis was adenocarcinoma of the ascending colon. Multiple nodules in both lungs and breast were observed on a chest CT scan. A core biopsy of a breast nodule was performed and a diagnosis of invasive ductal carcinoma of the left breast was made. Pulmonary nodules observed on the chest CT scan was considered as pulmonary metastasis from colon or breast cancer. Laparoscopic right hemicolectomy was performed. At the same time, wedge resection of the lung was performed and pathological diagnosis was PEH. Radiologic features of PEH were difficult to distinguish from lung metastasis. Therefore the author reported a rare case involving PEH in a patient with primary malignancy of colon and breast.

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Section: Discussionmentioning

confidence: 97%

“…Several studies reported that lack of these symptoms was associated with a lower risk for cancer progression [5,12].…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary epithelioid hemangioendothelioma misconceived as pulmonary metastasis of other malignancies

Noh

Lee

Sohn

et al. 2016

Yeungnam Univ J Med

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“…O curso clinico e o prognóstico são imprevisíveis 4,7,8 . São factores de mau prognóstico sintomatologia respiratória na altura do diagnóstico 2,4 , presença de doença multicêntrica, metastização hepática ou ganglionar 2,7 , anemia, hemorragia alveolar e derrame pleural hemático 8 . A sobrevida dos casos descritos na literatura varia entre 2 e 24 anos 4 .…”

Section: Discussionunclassified

“…O hemangioendotelioma epitelial (HE) é uma neoplasia rara com origem no endotélio vascular [2][3][4]7,8 . A apresentação pulmonar foi descrita pela primeira vez em 1975 por Dail e Liebow, que consideraram tratar-se de uma forma intravascular de carcinoma bronquioloalveolar [1][2][3][4][5]7 .…”

Section: Introductionunclassified

Hemangioendotelioma epitelial: um tumor raro com apresentação atípica

Reis¹,

Tavares²,

Ferreira³

et al. 2016

Gal. Clin.

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ResumenEl hemangioendotelioma epitelial es una neoplasia poco frecuente, y tiene su origen en el endotelio vascular. Puede crecer en varios órganos y tejidos. No hay ningún esquema terapéutico aprobado y el pronóstico es impredecible. Se presenta el caso de un paciente masculino de 54 años de edad, con el diagnóstico de hemangioendotelioma epitelioide pulmonar, con imagen atípica y la presentación clínica y la participación de múltiples órganos en el momento del diagnóstico. El paciente no comenzó la quimioterapia y murió dos meses después del diagnóstico histológico. Debido a la rareza de esta neoplasia y la inexistencia de régimen terapéu-tico aprobado, al reportar este caso, tenemos la intención de contribuir a los estudios clínicos futuros. Palabras clave: Pulmón. Hemangioendotelioma epitelioide. Inhibidores de la angiogénesis AbstractEpithelioid Hemangioendothelioma is a rare neoplasia, and has its origin in the vascular endothelium. It may grow in several organs and tissues. There is not any approved therapeutic scheme and the prognosis is unpredictable. It is reported the case of a 54-year-old male patient, with the diagnosis of pulmonary epithelioid hemangioendothelioma, with atypical imaging and clinical presentation and multiple organ involvement at the time of the diagnosis. The patient did not start chemotherapy and died two months after the histological diagnosis. Due to the rarity of this neoplasia and the inexistence of approved therapeutic scheme, by reporting this case we intend to contribute to future clinical studies.

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Primary malignant epithelioid hemangioendothelioma of the pleura: A review and report of a novel case

Rezvani

Shahriarirad

Erfani

et al. 2022

Clinical Case Reports

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Prognostic Factors and Surgical Indications of Pulmonary Epithelioid Hemangioendothelioma: A Review of the Literature

Cited by 167 publications

References 28 publications

Pulmonary epithelioid hemangioendothelioma misconceived as pulmonary metastasis of other malignancies

Pulmonary epithelioid hemangioendothelioma misconceived as pulmonary metastasis of other malignancies

Hemangioendotelioma epitelial: um tumor raro com apresentação atípica

Primary malignant epithelioid hemangioendothelioma of the pleura: A review and report of a novel case

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