Prognostic factors and survival of patients with brain metastasis from breast cancer who underwent craniotomy

Abstract

Brain metastasis (BM) in patients with breast cancer is a catastrophic event that results in poor prognosis. Identification of prognostic factors associated with breast cancer brain metastases (BCBM) could help to identify patients at risk. The aim of this study was to assess clinical characteristics, prognostic factors, and survival of patients with BCBM who had craniotomy and resection in a series of patients treated with modern multimodality therapy. We analyzed 42 patients with BCBM who underwent resection. Patients were diagnosed with breast cancer between April 1994 and May 2010. Cox proportional hazards regression was selected to describe factors associated with time to BM, survival from the date of first recurrence, and overall survival (OS). Median age was 51 years (range 24-74). Median follow-up was 4.2 years (range 0.6-18.5). The proportion of the biological subtypes of breast cancer was ER+/HER2À 25%, ER+/HER2+ 15%, ER-/ HER2+ 30%, and ER-/HER2À 30%. Median OS from the date of primary diagnosis was 5.74 years. Median survival after diagnosis of BM was 1.33 years. In multivariate Cox regression analyses, stage was the only factor associated with shorter time to the development of BM (P = 0.033), whereas age was the only factor associated with survival from the date of recurrence (P = 0.027) and with OS (P = 0.037). Stage at primary diagnosis correlated with shorter time to the development of BM, while age at diagnosis was associated with shorter survival in BCBM. None of the other clinical factors had influence on survival.

Adapting coculture in vitro models of the blood–brain barrier for use in cancer research: maintaining an appropriate endothelial monolayer for the assessment of transendothelial migration

“…It is important to note that triple-negative breast cancer patients commonly develop secondary tumors in peripheral organs (liver, bone, lung), 31 beyond brain metastases that often arise later during the disease progression. 32 For this reason, it has been suggested that breast cancer tumor cells need some time to develop their ability to penetrate through the BBB and colonize the brain. 33 In this frame, it would be interesting to investigate and compare the ability of metastatic breast cancer cells to interact with the endothelium from different organs (adhesion, transmigration processes).…”

Clinicopathological factors associated with survival in patients with breast cancer brain metastasis

“…Brain metastases in breast cancer generally represent a catastrophic event that presages dismal survival [10][11][12][13][14]. However, this malignancy represents a group of disease with substantial A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 4 biological and clinical heterogeneity.…”

Supra- and Infratentorial Cystic Metastases of Breast Cancer: Case Report

“…Leone ve ark., meme kanserinin teşhis anındaki evresi yüksek oldukça, teşhis ile beyin metastazı gelişmesi arasındaki sürenin o kadar kısa olduğunu göstermişlerdir (10). Nishimura ve ark., beyin…”