Prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma treated by intra‐arterial infusion chemotherapy concurrent with radiotherapy

Abstract

Background The aim of this study was to evaluate the prognostic factors and treatment outcomes of advanced maxillary gingival squamous cell carcinoma (SCC) treated with intra‐arterial infusion chemotherapy concurrent with radiotherapy. Methods A total of 46 patients were reviewed retrospectively in this study. The treatment schedule comprised intra‐arterial chemotherapy (total, 60 mg/m2 docetaxel and 150 mg/m2 cisplatin) and three‐dimensional computed tomography based, daily conventional radiotherapy (total, 60 Gy/30 fr) for 6 weeks. Results The median follow‐up period was 40 months (range, 3‐110 months). The 3‐year overall survival and locoregional control rates for all patients were 64.3% and 84.3%, respectively. The OS rate of the patients with N0‐1 was significantly higher than that of the patients with N ≥ 2 (P < .05). No grade 5 toxicities were observed. Conclusions Intra‐arterial infusion chemotherapy concurrent with radiotherapy was effective for advanced maxillary gingival SCC.

Impact of Superselective Intra-Arterial and Systemic Chemoradiotherapy for Gingival Carcinoma; Analysis of Treatment Outcomes and Prognostic Factors

“…Oral cancers are the 6th most common malignancy, comprising 1-3% of all malignancies. In Japan, gingival carcinoma (GC) is more common than in Western countries [1][2][3][4][5][6][7]. Surgical resection is the standard therapy for most oral cancers, especially early-stage disease, and is a well-established treatment for GC [2,8,9].…”

“…In Japan, gingival carcinoma (GC) is more common than in Western countries [1][2][3][4][5][6][7]. Surgical resection is the standard therapy for most oral cancers, especially early-stage disease, and is a well-established treatment for GC [2,8,9]. Other treatment options for oral cancers are combinations of radiation therapy (RT) including external beam RT and brachytherapy, and chemotherapy; these are considered to be organ-preserving treatments [1,6,8,10].…”

Impact of superselective intra-arterial and systemic chemoradiotherapy for gingival carcinoma; analysis of treatment outcomes and prognostic factors

“…Surgical resection is the standard therapy for most oral cancers, especially early-stage disease, and is a well-established treatment for GC [2,8,9]. Other treatment options for oral cancers include combinations of radiation therapy (RT) including external beam RT and brachytherapy, and chemotherapy, which are considered to be organ-preserving treatments [1,6,8,10].…”

Impact of superselective intra-arterial and systemic chemoradiotherapy for gingival carcinoma; analysis of treatment outcomes and prognostic factors

“…Oral cancers are the 6th most common malignancy, comprising 1-3% of all malignancies [1][2][3][4][5][6][7]. Gingival carcinoma (GC) represents < 10% of all oral cancers in Europe and the United States, compared with 15-20% of oral cancers in Japan [1][2][3][4][5][6][7].…”

“…Surgical resection is the standard therapy for most oral cancers, especially early-stage disease, and is a wellestablished treatment for GC [2,8,9]. Other treatment options for oral cancers include combinations of radiation therapy (RT) including external beam RT and brachytherapy, and chemotherapy, which are considered to be organ-preserving treatments [1,6,8,10].…”