Prognostic factors and treatment strategies for adult head and neck soft tissue sarcoma

González-González, Rogelio; Bologna‐Molina, Ronell; Molina-Frechero, Nelly; Domı́nguez-Malagón, Hugo

doi:10.1016/j.ijom.2012.02.002

Cited by 31 publications

(29 citation statements)

References 18 publications

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“…In the head and neck, the most frequent forms, taking all series together, are pleomorphic sarcoma (or malignant fibrous histiocytoma: MFH), fibrosarcoma, angiosarcoma, malignant peripheral nerve sheath tumor and non-classified/nondifferentiated sarcoma [3,[11][12][13][14][15][16][17][18][19] (Fig. 1).…”

Section: Epidemiology and Diagnosismentioning

confidence: 99%

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Head and neck soft-tissue sarcoma in adults

Galy-Bernadoy

Garrel

2016

European Annals of Otorhinolaryngology, Head and Neck Diseases

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Adult soft-tissue sarcoma is rare but aggressive, with incidence around 5 per 100,000 per year. Head and neck locations are infrequent. Genetic disease and irradiation are risk factors. The diagnosis needs to be known in order to avoid treatment delay. There are about 50 histologic subtypes, with different patterns and prognoses. Pathologic review and the development of molecular techniques are therefore essential. Prognosis in adult head and neck soft-tissue sarcoma (HNSTS) is poor: 5-year overall survival, about 60%. Recurrence is most often local. Prognostic factors are: tumor size and local extension, histologic grade and margin status. There are few targeted management guidelines. Surgical resection with negative margins is the primary treatment. Postoperative radiation therapy can improve prognosis. The role of chemotherapy is not well established. HNSTS should be treated in a reference center, with multidisciplinary staff following national network guidelines. Several factors are still unknown. The purpose of this article is to summarize the state of knowledge in adult HNSTS.

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Section: Epidemiology and Diagnosismentioning

confidence: 99%

“…The most frequent sites are superficial areas of the neck and parotid, nasal sinuses and cavities, and lastly the visceral spaces of the neck (pharynx, larynx) [3,[11][12][13][14][15][16][17][18][19][20][21] (Fig. 2).…”

Section: Epidemiology and Diagnosismentioning

confidence: 99%

Head and neck soft-tissue sarcoma in adults

Galy-Bernadoy

Garrel

2016

European Annals of Otorhinolaryngology, Head and Neck Diseases

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“…Soft tissue sarcomas are rarely occurring heterogeneous tumors derived from embryonic mesoderm [1]. They are primarily pediatric malignancies, having been shown to comprise up to 12% of pediatric malignancies, but as little as 1% of all adult malignancies [2].…”

Section: Introductionmentioning

confidence: 99%

Rhabdomyosarcoma of the Paranasal Sinuses Initially Diagnosed as Acute Sinusitis

et al. 2017

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Rhabdomyosarcoma (RMS) is an uncommon soft tissue malignancy that is typically found in the pediatric population. Here we describe a rare case of widely metastatic alveolar RMS of the right paranasal sinuses in an adult woman who presented with several months of unilateral sinus symptoms that was initially misdiagnosed as acute sinusitis. A middle-aged female presented with two months of right sinus pressure and unilateral epistaxis. She had previously been diagnosed with acute sinusitis and was treated with antibiotics without improvement. Nasal endoscopy demonstrated a fungating right nasal cavity mass. On computed tomography scan (CT), she was found to have metastatic disease in the mediastinum, lungs, bones, pancreas, and right ovary. Pathology of the nasal cavity mass was consistent with alveolar RMS. The patient initially responded well to chemotherapy, but subsequently developed brain and leptomeningeal metastases. This case of sinonasal rhabdomyosarcoma is unique in the extent of metastatic disease at the time of diagnosis and the initial misdiagnosis despite concerning unilateral symptoms and imaging. This thus highlights the importance of maintaining a high index of suspicion for malignancy in patients with unilateral sinus symptoms.

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“…Expected therapy have tall success zoom criterion, don't wreck normal tissues, and is not impacted negative to human viability. Ordinary therapy type is done for cancer patient are Chemotherapy (NCI, 2009;Barth, R.F., et al 2005;Noble, S., et al 2014;Gorey et al 2014), radiotherapy (NCI, 2009;Barth, R.F., et al 2005;Stupp, R., et al 2005;Saurwein, W., et al 2012), and dissection (NCI, 2009;Wu, J., et al 2015;R. Gonza ´ lez Gonza ´ lez, et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Operate is utilized on early phase therapy, where does tumor be still gets tame character (Abeloff and Martin, 2008 Savolainen, S., et al 2012;Helsinki, 2014). Specifically for therapy raising hell cancer as head and neck cancer(R. Gonza ´ lez Gonza ´ lez, et al 2012;Yu, Hui Ting., et al without year;Helsinki, 2014), prostate cancer (Yasui,L., et al 2012), oral cancer (Yura, Y. And Fujita, Y., 2013;Heber, E.M., et al 2012;Trivellin,V.…”

Section: Introductionmentioning

confidence: 99%

Basic Principle Application and Technology of Boron Neutron Capture Cancer Therapy (BNCT) Utilizing Monte Carlo N Particle 5’S Software (MCNP 5) with Compact Neutron Generator (CNG)

Payudan

Aziz

Sardjono³

2016

ijpna

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The purpose are to know basic principle, needed component, types of compact neutron generator, plus and minus CNG, identify materials can use as collimator, know physics parameters as input software MCNP 5, knowing step simulation with software MCNP 5, dose in BNCT, knowing boron compound that use in BNCT, getting collimator design for BNCT'S application with source is compact neutron generator and count physics parameter of collimator output and compares it with standard IAEA. Method are reading reference and simulation with MCNP 5. The result are BNCT use high linear energy transfer from alpha and lithium as a result of 10 B(n,α) 7 Li reaction. BNCT method is effective for cancer therapy. It is not dangerous to normal tissues. To work perfectly, BNCT needs neutron, boron (BSH and BPA as boron compound) Indonesia have study turmeric as boron compound, neutron source, collimator and dose. Dose component in BNCT that important are dose of recoil proton, dose of gamma, dose alfa and dose radiation to environmentally. CNG produce neutron with fussion reaction of deuterium-deuterium (2,45 MeV), deuterium-tritium (14 MeV), tritium-tritium(11,31 MeV) can used as neutron source BNCT. Many kinds of CNG are axial, coaxial, toroidal, plasma design, accelerator design, and CNG with diameter 2,5 cm. CNG have more benefit than another neutron source, make CNG compatible as BNCT application. Neutron from CNG need collimator to get neutron as IAEA's parameter. Material for collimator are wall and aperture (material: Ni, Pb, Bi), moderator (Al, Al 2 O 3, S, AlF 3 ), filter ( 6 Li, 10 B, LiF, Al, Cd-nat, Ni-60, BiF 3 , 157 Gd, 151 Eu), gamma shield (Bi, Pb). Simulation using MCNP 5 has severally steps, the first is sketching problem, the second is making listing program with notepad, the third open program on visual editor, and the last is running program. Acquired result is design tube collimator with radius 71 cm and high 139, 5 cm. Design contained on lead wall as thick as 19, 5 cm; moderate: heavy water as thick as 4 cm, AlF 3 girdle a half of part CNG, MgF 2 (19 cm + 10 cm), Al (6,5 cm + 5 cm);Gamma shield: bismuth, and aperture with diameter 6 cm by steps aside nickel. The result collimator output cross three of five IAEA'S defaults. They are the ratio among dosed gamma with flux epithermal is 5,738×10 -24 Gy. cm 2 .n -1, the value of ratio among thermal's neutron flux with epithermal neutron is 0, 02567, and ratio among current with flux neutron completely is 1, 2. Need considerable effort of all part to realize BNCT in Indonesia.

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Prognostic factors and treatment strategies for adult head and neck soft tissue sarcoma

Cited by 31 publications

References 18 publications

Head and neck soft-tissue sarcoma in adults

Head and neck soft-tissue sarcoma in adults

Rhabdomyosarcoma of the Paranasal Sinuses Initially Diagnosed as Acute Sinusitis

Basic Principle Application and Technology of Boron Neutron Capture Cancer Therapy (BNCT) Utilizing Monte Carlo N Particle 5’S Software (MCNP 5) with Compact Neutron Generator (CNG)

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