Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis

Tran, Alexandre; Rochwerg, Bram; Fan, Eddy; Belohlavek, Jan; Suverein, Martje M.; Poll, Marcel C.G. van de; Lorusso, Roberto; Price, Susanna; Yannopoulos, Demetris; MacLaren, Graeme; Ramanathan, Kollengode; Ling, Ryan Ruiyang; Thiara, Sonny; Tonna, Joseph E.; Shekar, Kiran; Hodgson, Carol L.; Scales, Damon C.; Sandroni, Claudio; Nolan, Jerry P.; Slutsky, Arthur S.; Combes, Alain; Brodie, Daniel; Fernando, Shannon M.

doi:10.1016/j.resuscitation.2023.110004

Cited by 12 publications

(3 citation statements)

References 73 publications

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“…ECMO has been reported in clinical trials and observational studies to improve survival rates with favorable neurological outcomes, compared to standard ACLS measures. 4 The International Liaison Committee on Resuscitation (ILCOR) guidelines currently advocate for the use of VA-ECMO as a resuscitation method in cases of refractory OHCA. This recommendation includes cases where the cause of cardiac arrest is drowning or hypothermia.…”

Section: Discussionmentioning

confidence: 99%

“…Early application of ECMO, with blood flow starting within 60 min, is crucial for enabling this advanced treatment with the possibility of a good outcome. 4 , 6 , 7 , 14 However, transferring a patient from the scene of an OHCA while maintaining ongoing CPR within one hour presents a challenging task. Cannulation by a HEMS team in a prehospital setting could significantly reduce low-flow times in carefully selected patients.…”

Section: Discussionmentioning

confidence: 99%

“… 3 Clinical studies have demonstrated the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cases of out-of-hospital cardiac arrest (OHCA), over standard advanced cardiac life support (ACLS) in selected patients, as ECPR facilitates immediate hemodynamic and respiratory stabilization of patients experiencing refractory cardiac arrest. 4 , 5 , 6 , 7 Therefore, guidelines recommend considering ECPR in cases of OHCA where conventional cardiopulmonary resuscitation (CPR) fails to restore spontaneous circulation, provided that the necessary infrastructure is available for its implementation. 8 This recommendation extends to OHCA related to drowning.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Successful prehospital ECMO in drowning resuscitation after prolonged submersion

Seesink,

van der Wielen,

Dos Reis Miranda

et al. 2024

Resuscitation Plus

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Successful prehospital ECMO in drowning resuscitation after prolonged submersion

Seesink,

van der Wielen,

Dos Reis Miranda

et al. 2024

Resuscitation Plus

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Short-Term Neurologic Complications in Patients Undergoing Extracorporeal Membrane Oxygenation Support: A Review on Pathophysiology, Incidence, Risk Factors, and Outcomes

Pisano,

Ortoleva,

Wieruszewski

2024

Pulm Ther

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Regardless of the type, extracorporeal membrane oxygenation (ECMO) requires the use of large intravascular cannulas and results in multiple abnormalities including non-physiologic blood flow, hemodynamic perturbation, rapid changes in blood oxygen and carbon dioxide levels, coagulation abnormalities, and a significant systemic inflammatory response. Among other sequelae, neurologic complications are an important source of mortality and long-term morbidity. The frequency of neurologic complications varies and is likely underreported due to the high mortality rate. Neurologic complications in patients supported by ECMO include ischemic and hemorrhagic stroke, hypoxic brain injury, intracranial hemorrhage, and brain death. In addition to the disease process that necessitates ECMO, cannulation strategies and physiologic disturbances influence neurologic outcomes in this high-risk population. For example, the overall documented rate of neurologic complications in the venovenous ECMO population is lower, but a higher rate of intracranial hemorrhage exists. Meanwhile, in the venoarterial ECMO population, ischemia and global hypoperfusion seem to compose a higher percentage of neurologic complications. In what follows, the literature is reviewed to discuss the pathophysiology, incidence, risk factors, and outcomes related to short-term neurologic complications in patients supported by ECMO.

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Signs of life as a favorable predictor for non-shockable cardiac arrest undergoing extracorporeal cardiopulmonary resuscitation post non-shockable cardiac arrest

Bunya,

Ohnishi,

Kasai

et al. 2025

The American Journal of Emergency Medicine

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Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis

Cited by 12 publications

References 73 publications

Successful prehospital ECMO in drowning resuscitation after prolonged submersion

Successful prehospital ECMO in drowning resuscitation after prolonged submersion

Short-Term Neurologic Complications in Patients Undergoing Extracorporeal Membrane Oxygenation Support: A Review on Pathophysiology, Incidence, Risk Factors, and Outcomes

Signs of life as a favorable predictor for non-shockable cardiac arrest undergoing extracorporeal cardiopulmonary resuscitation post non-shockable cardiac arrest

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