2003
DOI: 10.1016/s0304-3835(02)00715-2
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Prognostic factors associated with the clinical outcome of cervical intraepithelial neoplasia: a cohort study in Japan

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Cited by 25 publications
(25 citation statements)
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References 26 publications
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“…O elevado número de pacientes portadoras de NIC, nas quais não se identificou DNA-HPV pela técnica de PCR no estudo atual, assemelha-se aos resultados de outras pesquisas 15 . Para esses autores, a justificativa do encontro de 80% de portadoras de NIC 1 sem a presença de DNA-HPV, em estudo por eles realizado, parece adequada também para a elevada negatividade de DNA-HPV da presente pesquisa.…”
Section: Características Do Tabagismounclassified
See 1 more Smart Citation
“…O elevado número de pacientes portadoras de NIC, nas quais não se identificou DNA-HPV pela técnica de PCR no estudo atual, assemelha-se aos resultados de outras pesquisas 15 . Para esses autores, a justificativa do encontro de 80% de portadoras de NIC 1 sem a presença de DNA-HPV, em estudo por eles realizado, parece adequada também para a elevada negatividade de DNA-HPV da presente pesquisa.…”
Section: Características Do Tabagismounclassified
“…Para esses autores, a justificativa do encontro de 80% de portadoras de NIC 1 sem a presença de DNA-HPV, em estudo por eles realizado, parece adequada também para a elevada negatividade de DNA-HPV da presente pesquisa. Afirmam que "HPV negativo necessariamente não significa sempre negativo", justificando que em muitos casos a seqüência de DNA-HPV pode ser positiva, porém em quantidade de nucleotídeos tão pequena que os métodos atuais não permitem detectar 15 .…”
Section: Características Do Tabagismounclassified
“…Carcinogenicity of the high-risk HPV (hrHRV) is closely associated with E6 and E7 proteins, which can respectively inhibit activities of tumor suppressors, p53 and retinoblastoma protein (pRB), to interrupt cell growth regulation (10). Besides carcinogenesis, persistent HPV infection further correlates with tumor recurrence, cancer cell radiosensitivity and the resulting poor prognosis (11)(12)(13).…”
Section: Introductionmentioning
confidence: 99%
“…The prevalence and distribution of type 58 were correlated with cytological malignancies, with the highest prevalence in women with HSILs. In conclusion, the novel multiplex PCR method described appears to be highly suitable not only for the screening of cervical cancer precursor lesions but also for the characterization of genotype distributions in large-scale epidemiological studies and HPV vaccination trials.Accumulating evidence indicates that persistent infection with high-risk human papillomaviruses (HPVs) is indeed a major causative factor in the development of cervical intraepithelial neoplasia and invasive cervical carcinoma (42,10,8,5,40,27,11,30). The HPV family includes over 100 genotypes, 30 to 40 of which are mucosotropic, and at least 15 types of the mucosotropic HPVs have been linked to cervical cancer (5,8,10,42).…”
mentioning
confidence: 99%
“…Light microscopic examination of a Papanicolaou (Pap)-stained smear is of primary importance for the detection of cervical cancer precursor lesions. It has been demonstrated that concomitant testing for DNA of the highrisk HPV types by the Pap test can clearly identify women at high risk for cervical cancer, particularly if persistent infection by high-risk HPV types is diagnosed (5,8,10,11,27,30,40). Furthermore, HPV genotyping is of critical importance for the investigation of the clinical behavior and the epidemiology of HPV infection, for population studies for HPV vaccination trials, and for monitoring of the efficacy of HPV vaccines.…”
mentioning
confidence: 99%