Prognostic factors for disease-specific survival in 108 patients with Hürthle cell thyroid carcinoma: a single-institution experience

Abstract

BackgroundHürthle cell thyroid carcinoma (HCTC) is a rare disease. It is believed that it is more aggressive than follicular thyroid carcinoma. The aim of our study was to identify factors associated with disease-specific and disease-free survival.MethodsAltogether, 108 patients with HCTC (26 male, 82 female; median age 62 years; range 19–87 years) treated at our Institute from 1972 to 2011 were included in the present retrospective study. Data on age, clinical and histopathological factors, tumor stage, recurrence, disease-free and disease-specific survival were collected. Univariate analysis was used to identify factors associated with disease-specific survival. Cox’s multivariate regression model was used to identify independent prognostic factors for disease-specific survival.ResultsThe follow-up period was 1 to 337 (median 105) months. Of 108 patients, 12 (11%) had distant and 8 (7%) had locoregional metastases before primary treatment. Recurrence was diagnosed in 26 cases (24%): locoregional, distant, and both locoregional and distant in 12, 11, and 3 cases, respectively. The 5-year, 10-year, and 20-year disease-specific survival were 96%, 88%, and 67%, respectively. Independent prognostic factors for disease-specific survival were: age of patients at diagnosis, distant metastases and residual tumor after surgery.ConclusionLong disease-specific survival was found in patients with HCTC younger than 45 years of age without distant metastases and without residual tumor after surgery.

Carcinoma de células de Hürthle. Análisis cooperativo de los dos hospitales oncológicos de la Ciudad de Buenos Aires

“…El compromiso ganglionar en la literatura oscila entre 7 y 30% 4,6 . En la serie propia, la frecuencia de afección ganglionar laterocervical fue mayor del 40%.…”

“…Se considera que el CCH es una enfermedad más agresiva y de peor pronóstico que el resto de los CDT, dada su propensión a originar metástasis ganglionares, diseminación a distancia y recaídas tardías 2,4,6 . El objetivo es comunicar la experiencia de dos centros oncológicos en el manejo de pacientes con diagnóstico histológico de CCH, el Instituto de Oncología Ángel H. Roffo y el Hospital de Oncología María Curie.…”

“…Este hallazgo no fue confirmado por otros autores 4,6 . La radioterapia externa tiene utilidad solo en el tratamiento de metástasis sintomáticas, recidivas y en la prevención de recurrencias en pacientes avanzados 6,8,22 .…”

Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid

“…Further evaluations revealed that unstable 53BP1 expression had a significant positive correlation with the levels of expression of Tumor protein 73. These data suggest a higher level of genomic instability in oncocytic FA compared with conventional FA, and a possible relationship between oncocytic FA and abnormal amplification of Tumor protein 73.Key words: Thyroid oncocytic tumor, 53BP1, DNA damage response, Genomic instability plasms of follicular cell origin predominantly, or entirely, composed of large polygonal cells with oxyphilic features related to the presence of eosinophilic and granular cytoplasm that is rich in mitochondria [1][2][3]. Encapsulated thyroid lesions with no evidence of capsular or vascular invasion and no nuclear features of papillary carcinoma are diagnosed as onco-…”

“…Key words: Thyroid oncocytic tumor, 53BP1, DNA damage response, Genomic instability plasms of follicular cell origin predominantly, or entirely, composed of large polygonal cells with oxyphilic features related to the presence of eosinophilic and granular cytoplasm that is rich in mitochondria [1][2][3]. Encapsulated thyroid lesions with no evidence of capsular or vascular invasion and no nuclear features of papillary carcinoma are diagnosed as onco-…”