Prognostic factors for lethal outcome in early postoperative pediatric liver transplantation

Prodanova, Krasimira; Uzunova, Yordanka; Spassov, Lubomir

doi:10.1063/1.5133599

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…In this section we compare the performance of the four models described in Sections 2.2-2.5 to the prediction of mortality in early postoperative periods after pediatric liver transplantation (LT). The use of the logistic model for this purpose has been considered in [9,8,6]. The Model for Early Allograft Function (MEAF) is the first statistically confirmed score for diagnosis of Early Allograft Dysfunction (EAD).…”

Section: Prediction Of Mortalitymentioning

confidence: 99%

“…pMELD can help in assessing the need for re-transplantation. Uzunova et al [6] published results of a retrospective study of liver transplant children using pMELD as a predictor of lethal outcome after liver transplantation. An univariate analysis was used and the constructed binary models using pMELD on postoperative day 5 (data (X 2 , Y)) predicted disadvantageous outcome after LT with good statistical significance (p < 0.05).…”

Section: Prediction Of Mortalitymentioning

confidence: 99%

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Comparison of Binary Regression Models for the Outcome of Pediatric Liver Transplantation

Uzunova¹,

Prodanova²

2022

Int. J. of Appl. Math.

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Section: Prediction Of Mortalitymentioning

confidence: 99%

Section: Prediction Of Mortalitymentioning

confidence: 99%

Comparison of Binary Regression Models for the Outcome of Pediatric Liver Transplantation

Uzunova¹,

Prodanova²

2022

Int. J. of Appl. Math.

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“…The EASE score was developed through 17 entries derived from 8 variables, including the Model for End-stage Liver Disease (MELD) score, blood transfusion, early thrombosis of hepatic vessels, and kinetic parameters of transaminases, platelets count, and bilirubin [5]. Postoperative Model for End-Stage Liver Disease (pMELD) was also analyzed as a predictor of mortality in a constructed logistic model [6,7].…”

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confidence: 99%

The efficacy of two models – MEAF and pMELD, as indicators of lethal outcome in early postoperative period after liver transplantation in children

Goncharov,

Uzunova

2023

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The current study is aiming to prove the effectiveness and compare “Model for Early Allograft Function” (MEAF) and “postoperative Model for End-stage Liver Disease” (pMELD) in the early posttransplant setting in children. Methods. We did a retrospective study on 43 liver transplant patients for a 17-year period between the ages 0 – 18 years. MEAF and pMELD were calculated on the third and fifth postoperative day, respectively, and a Cox regression analysis was performed to find the correlation between them and mortality in the early postoperative period (EPOP). Results. Both scores proved to be statistically significant and applicable in EPOP. MEAF had P value of 0.0003 and a hazard ratio of 10.99, while pMELD demonstrated P value of 0.003 and a hazard ratio of 1.24. Conclusions. Both MEAF and pMELD can be used for the diagnostics of early allograft dysfunction and predicting the outcome of the transplantation, with MEAF having the upper hand.

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Prognostic factors for lethal outcome in early postoperative pediatric liver transplantation

Cited by 2 publications

References 9 publications

Comparison of Binary Regression Models for the Outcome of Pediatric Liver Transplantation

Comparison of Binary Regression Models for the Outcome of Pediatric Liver Transplantation

The efficacy of two models – MEAF and pMELD, as indicators of lethal outcome in early postoperative period after liver transplantation in children

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