Prognostic factors for survival in advanced appendiceal cancers

Khan, Fatima; Diep, Gustave K; Tuttle, Todd M.; Lou, Emil

doi:10.3233/cbm-160662

Cited by 9 publications

(6 citation statements)

References 27 publications

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“…In recent years, as a noninvasive detection method, serum biomarkers have attracted more and more attention because of their simple operation and large predictive potential [ 3 ]. Several studies have shown that the systemic immune-inflammation index (SII) is related to the prognosis of malignant tumors [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer

Shao

Zhang

et al. 2020

Gastroenterology Research and Practice

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Background. Multiple studies have reported the significance of the systemic immune-inflammation index (SII) in the prognosis of colorectal cancer (CRC), but no consensus has yet been reached. The purpose of this study was to systematically assess the prognostic value of SII in patients with CRC. Materials and Methods. We performed a systematic literature search in PubMed, Embase, and the Cochrane Library for eligible studies. The correlation between pretreatment SII and overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) in CRC patients was evaluated by combining the hazard ratio (HR) and 95% confidence interval (CI). Results. Twelve studies involving 3919 patients were included. Comprehensive analysis results showed that high SII indicated poor OS in CRC patients ( HR = 1.777 , 95% CI: 1.328-2.376). Compared with patients with low SII values, patients with high SII had lower PFS ( HR = 1.658 , 95% CI: 1.189-2.311). Subgroup analysis further verified the above results. Conclusions. SII may be a noninvasive and powerful tool for predicting survival outcomes in CRC patients. However, more well-designed studies are needed to validate our findings.

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Section: Introductionmentioning

confidence: 99%

Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer

Shao

Zhang

et al. 2020

Gastroenterology Research and Practice

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“…11,12 In a previous study, for malignant appendiceal tumors, NLR and PLR did not appear to be predictive of OS, but the sample size was also relatively small. 13 Their result demonstrated histological grade was more important than inflammatory markers. Our conclusion is compatible with their study.…”

Section: Discussionmentioning

confidence: 98%

“…Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified as inflammation markers, which are also used as prognostic factors in cancer. 11,12 A previous study proposed that NLR and PLR were not predictive of overall survival (OS) in advanced appendiceal carcinoma 13 ; this study combined all malignant appendiceal tumors. However, the prognostic values of NLR and PLR are still unclear in LAMN.…”

Section: Introductionmentioning

confidence: 93%

Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on low-grade appendiceal mucinous neoplasm: A single tertiary hospital experience

Kuan

Liang

Lin

et al. 2022

Journal of the Chinese Medical Association

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Background: Low-grade appendiceal mucinous neoplasm (LAMN) is a rare disease, which prognostic factors were difficult to evaluate. Inflammation markers, like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), were used as prognosticators for various cancers. This study aimed to investigate the prognostic value of pretreatment NLR and PLR on LAMN. Methods: From January 2000 to September 2018, there were 57 patients diagnosed with LAMN in Taipei Veterans General Hospital. Patients diagnosed with mucinous cystadenoma, mucinous tumor with uncertain malignant potential before 2010 were also included based on previous classification. Clinical and pathological data were collected. Patients were separated into high-NLR (NLR-H) and low-NLR (NLR-L) groups according to cutoff value of 3. Similarly, they were separated into high-PLR (PLR-H), and low-PLR (PLR-L) groups with cutoff value of 300. Overall survival (OS) and recurrence-free survival (RFS) were analyzed. Results: Among all patients, the median follow-up time was 42 months. Age, gender, clinical manifestations, type of surgery, and T stage were similar in different NLR and PLR groups. Both NLR-H and PLR-H groups had higher rate of M1 stage of diseases (22.7% vs 9.4%, p = 0.04; 57.1% vs 8.8%, p < 0.01, respectively). PLR-H group had more presence of pseudomyxoma peritonei (PMP) (57.1% vs 15.2%, p = 0.03). In univariate analysis, factors such as age, gender, tumor perforation, and operation did not have impact on OS nor RFS. On the other hand, M1b stage is the only significantly poor prognostic factor on RFS (hazard ratio, 57.96, 95% CI, 5.16-651.23, p < 0.01). Conclusion: Both NLR-H and PLR-H had more M1 stage of diseases, but they were not correlated to OS nor RFS. PLR-H group had higher rate of presence PMP. Nevertheless, patients with LAMN and cellular PMP (M1b stage) had a higher rate of recurrence, and other factors showed no statistical difference in OS nor RFS.

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“…Appendiceal tumors are rare, about 0.9%-1.4% of the tumors are seen during histology diagnosis of resected appendiceal specimens. The age-adjusted incidence is 0.12 cases per one million people per year [ 9 ], it is reported in both genders, however, some authors claim that the majority of patients were female [ 10 , 11 ]. The most common primary appendiceal tumor is carcinoid tumor and it makes up 32-85% while adenocarcinomas (mucinous, signet ring, or non-mucinous) make up 4-20% of the tumors [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…All the patients in this study with advanced disease were offered adjuvant treatment such as right hemicolectomy, cytoreductive surgery, or chemotherapy. Appendicular carcinoma exhibit a variable spectrum of biological behavior, the patient gender, and tumor pathomorphological are associated with OS (overall survival) in advanced cases of appendiceal carcinoma [ 10 ]. The published reports have shown that elevated pre-management tumor marker levels as CEA, CA 19-9 and CA125, to be associated with higher rates of disease recurrence and reduced survival after complete cytoreductive surgery.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Carcinoma in Appendectomy Specimens for Patients Presenting With Acute Appendicitis: A Single-Center Study

Lesi¹,

Walton²,

Appaiah³

et al. 2021

Cureus

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Introduction Acute appendicitis is the most common general surgical emergency globally. Its etiology includes the presence of luminal obstruction by faecoliths, lymphoid hyperplasia, impacted stool, and rarely by appendiceal or caecal cancer. Malignancy related to acute appendicitis is usually seen in the older age group. Aim To identify the subset rate of patients operated for acute appendicitis who have appendiceal carcinoma and analyze the outcome of their post-operative management. Material and methods A retrospective study of a cohort of 529 patients aged > 40 diagnosed with acute appendicitis with subsequent appendectomy in the period between 1 January 2014 and 31 December 2019 at Basildon and Thurrock University Hospital, Essex, United Kingdom was conducted. We analyzed the clinical data of the cohort including demographic information, diagnosis, pre-operative imaging, histological diagnosis as well as post-operative management where indicated. Results The median age of patients was 54.5 years (range 40-92). The male to female ratio in the appendicectomy cohort was 1:1.1. About 45% were aged 40-49 years, 24.8% were aged 50-59 and 30.2% were ≥60 years. Post-operative histology revealed acute appendicitis in 82.4% of the group. In 11% of the patients, the histology revealed the presence of other benign pathology as mucocele of the appendix, acute diverticulitis, follicular hyperplasia, and fibrous obliteration. The diagnosis of appendicular malignancy was seen in 1.9%. Conclusion Incidental appendiceal cancers in the resected specimens after acute appendicitis are rare but may be associated with a poor prognosis. It is recommended to consider such diagnosis in particular when dealing with acute appendicitis in older patients with longer symptom history, and in presence of peri-appendicular mass.

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Prognostic factors for survival in advanced appendiceal cancers

Cited by 9 publications

References 27 publications

Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer

Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer

Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on low-grade appendiceal mucinous neoplasm: A single tertiary hospital experience

Prevalence of Carcinoma in Appendectomy Specimens for Patients Presenting With Acute Appendicitis: A Single-Center Study

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