Prognostic factors for T1–T2 squamous cell carcinomas of the mobile tongue: A retrospective cohort study

Bonnardot, L.; Bardet, É.; Steichen, Olivier; Cassagnau, E.; Piot, B.; Salam, Alex P.; Campion, Loı̈c; Ferron, Christophe; Montreuil, C Beauvillain de; Malard, O.

doi:10.1002/hed.21567

Cited by 29 publications

(23 citation statements)

References 23 publications

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“…Shim et al also found that, when compared to well‐differentiated tumors of the oral tongue, moderately or poorly differentiated tumors resulted in nearly a 7‐fold increased risk of mortality (HR = 6.93; p = 0.001). However, other studies have shown no survival impact of tumor grade or margin involvement . Our study findings are congruent with the latter studies in that tumor grade and margin involvement were not independent predictors of survival.…”

Section: Discussionsupporting

confidence: 89%

TNM staging compared with a new clinicopathological model in predicting oral tongue squamous cell carcinoma survival

2014

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Section: Discussionsupporting

confidence: 89%

TNM staging compared with a new clinicopathological model in predicting oral tongue squamous cell carcinoma survival

2014

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“…Several adverse pathological features like increasing DOI, perineural invasion, and lympho‐vascular invasion have been implicated in poor outcomes in OSCC. Amongst these, the prognostic implications of DOI and tumour thickness in OSCC have been well‐reported . The major changes in AJCC eighth edition included the incorporation of DOI into the staging system and exclusion of extrinsic muscle involvement from T4 staging of tongue cancers.…”

Section: Discussionmentioning

confidence: 99%

Validation of the eighth edition AJCC staging system in early T1 to T2 oral squamous cell carcinoma

Murthy

Low

Subramaniam

et al. 2018

Journal of Surgical Oncology

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Background To validate the newly proposed American Joint Committee on Cancer (AJCC) eighth edition staging in early T1 and T2 oral cavity cancers and its effect in predicting tumour control. Methods Retrospective analysis of treatment outcomes of 441 T1 to T2 oral squamous cell carcinoma (OSCC). Overall survival (OS), disease‐specific survival (DSS), and tumour control were calculated and compared between the AJCC 7 and 8 staging systems. Results The 5‐year OS was 78% and 61% for T1 and T2 tumours, respetively (P < 0.001) (AJCC 7) vs 87% and 67% (P < 0.001) (AJCC 8). The 5‐year DSS was 78% and 61% for T1 and T2, respectively (P < 0.001) (AJCC 7) vs 89% and 71% (P < 0.001) (AJCC 8). For stages I and II tumours the 5‐year OS was 81% and 76%, respectively (P < 0.302) (AJCC 7) vs 87% and 73% (P < 0.017) (AJCC 8). The 5‐year DSS was 83% and 82% (P < 0.222) vs 89% and 77% (P < 0.016). With the AJCC eighth edition the 5‐year local, regional, and distant control rates for T1 vs T2 tumours were 85% vs 74% (P = 0.003), 95% vs 77% (P = 0.001), and 95% vs 80% (P = 0.014), respectively. Conclusion The AJCC 8th staging system provided for more accurate prediction of OS, DSS, and disease control in early oral cavity cancers.

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“…Thus, the composition of bacterial flora might also have a TLR5-dependent effect on cancer development. Oral tongue squamous cell carcinoma has low 5-year survival (Sano and Myers, 2007), but there are no clinically practical markers for risk assessment of OTSCC survival or recurrence (Bello et al , 2011; Bonnardot et al , 2011; Kim et al , 2011). Our study provides evidence for a relationship of TLR5 expression levels and prognosis in OTSCC.…”

Section: Discussionmentioning

confidence: 99%

“…Even with the recent advances in their treatment, the 5-year survival remains around 50% (Sano and Myers, 2007). Various molecular markers and factors have been proposed for risk assessment of OTSCC survival or recurrence, but none are currently in clinical use (Bello et al , 2011; Bonnardot et al , 2011; Kim et al , 2011). …”

mentioning

confidence: 99%

Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue

et al. 2013

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Background:Toll-like receptor 5 (TLR5) is an immune receptor recognising bacterial flagellin. Activation of TLR5 results in cancer invasion and cytokine release. As certain bacteria have been linked to oral cancer, we wanted to study TLR5 expression in oral tongue squamous cell carcinoma (OTSCC).Methods:Samples from 119 patients with OTSCC were obtained, including 101 samples of adjacent normal lingual mucosa. The TLR5 histoscore (0–300) was assessed semiquantitatively by immunohistochemistry in a blinded manner.Results:Toll-like receptor 5 was expressed in 84 normal epithelia and 118 cancer samples. Expression of TLR5 was increased in cancer when compared with normal lingual epithelium (median histoscore 15 vs 135). In cancer, higher TLR5 was associated with age of >70 years at the time of diagnosis, female gender and disease recurrence. No association between TLR5 expression and tumour grade, stage or treatment was found. In multivariate analysis, TLR5 was an independent predictor of cancer mortality (hazard ratio (HR) 3.587, 95% confidence interval (CI) (1.632–7.882)) and disease recurrence (HR 4.455, 95% CI (2.168–9.158)).Conclusion:Toll-like receptor 5 has a previously undescribed role in the pathophysiology of OTSCC and might represent a link between bacteria and cancer. It could be a useful marker for predicting recurrence or survival of OTSCC patients.

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Prognostic factors for T1–T2 squamous cell carcinomas of the mobile tongue: A retrospective cohort study

Abstract: This study corroborates several known prognostic factors and indicates that diagnosis of oral lichen planus may be a risk factor for disease recurrence.

Cited by 29 publications

References 23 publications

TNM staging compared with a new clinicopathological model in predicting oral tongue squamous cell carcinoma survival

TNM staging compared with a new clinicopathological model in predicting oral tongue squamous cell carcinoma survival

Validation of the eighth edition AJCC staging system in early T1 to T2 oral squamous cell carcinoma

Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue

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