2021
DOI: 10.3390/cancers13133142
|View full text |Cite
|
Sign up to set email alerts
|

Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature

Abstract: In high-income countries, the overall survival of children with Wilms tumors (WT) is ~90%. However, overall, 15% of patients experience tumor recurrence. The adverse prognostic factors currently used for risk stratification (advanced stage, high risk histology, and combined loss of heterozygosity at 1p and 16q in chemotherapy-naïve WTs) are present in only one third of these cases, and the significance of these factors is prone to change with advancing knowledge and improved treatment regimens. Therefore, we p… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
36
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 41 publications
(38 citation statements)
references
References 141 publications
2
36
0
Order By: Relevance
“…The most common form of urologic cancer in children is Wilms tumor (2).Current treatment strategies for Wilms tumor include surgery, chemotherapy and radiotherapy. In high-income countries, 90% of patients with this tumor survive (3). While the OS in high, 20% of patients relapse after first-line therapy and up to 25% of survivors report severe late morbidity of treatment (4,5).And the treatment of children with bilateral, high-risk tumors remains challenging (6).…”
Section: Introductionmentioning
confidence: 99%
“…The most common form of urologic cancer in children is Wilms tumor (2).Current treatment strategies for Wilms tumor include surgery, chemotherapy and radiotherapy. In high-income countries, 90% of patients with this tumor survive (3). While the OS in high, 20% of patients relapse after first-line therapy and up to 25% of survivors report severe late morbidity of treatment (4,5).And the treatment of children with bilateral, high-risk tumors remains challenging (6).…”
Section: Introductionmentioning
confidence: 99%
“…37 In a recent review of prognostic factors for recurrence in WT, underweight at diagnosis was not discussed as a prognostic factor, likely as less relevant for HICs. 38 Our observation of a lower weight at diagnosis as an independent risk factor for the adverse outcome is unique in the context of WT. Identifying malnutrition and nutritional rehabilitation should be a key intervention for improving the survival of patients with WT in LMICs.…”
Section: Treatment Abandonmentmentioning
confidence: 84%
“…The NWTS-5 and a study from South Africa did not observe a significant influence of undernutrition on overall outcome in WT. 36,38 A meta-analysis evaluating the nutritional status and its influence on outcome in pediatric solid tumors included only one eligible study on WT. 37 In a recent review of prognostic factors for recurrence in WT, underweight at diagnosis was not discussed as a prognostic factor, likely as less relevant for HICs.…”
Section: Treatment Abandonmentmentioning
confidence: 99%
“…The curability rate for patients with localized disease is 85%. In stage IV, HR usually reaches 50-60% [16,19]. For 5 years after the end of treatment, regular clinical check-ups are performed at increasing intervals, the most intensive ones shortly after the end of treatment.…”
Section: Prognosismentioning
confidence: 99%