Prognostic factors in atopic dermatitis

Rystedt, I.

doi:10.2340/0001555565206213

Cited by 63 publications

(2 citation statements)

References 6 publications

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“…They suggest that their report provides evidence for a pathogenesis of delayed type at the basis of AD. Regarding pediatric asthma, it is increasingly appreciated that AD can be associated with respiratory allergy (25-51% of cases) [21]: children with AD can have a latent predisposition to asthma [22], significantly more elevated if they have a smoking mother [23] or an early onset of AD [24]; in addition AD worsens in spring in children allergic to pollens. Studies have also reported that asthma develops in infants aged 0 to 1 year (3).…”

Section: Advances In Biotechnology and Microbiologymentioning

confidence: 99%

“…Studies have also reported that asthma develops in infants aged 0 to 1 year (3). Thirty-five percent of 500 children aged 6 years were asthmatic, 50 % if suffering from severe AD, and only 15% if from mild AD [25], showing that asthma starts earlier and more frequently in children affected with more severe manifestations [24,26].…”

Section: Advances In Biotechnology and Microbiologymentioning

confidence: 99%

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Respiratory Manifestations of Food Allergy in Babies with Atopic Dermatitis: A Prospective Study in 395 Children

Cantani¹

2016

AIBM

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Background Scientific evidence accumulated in recent years indicates that food and inhalant allergens can trigger atopic dermatitis (AD). It may be hypothesized that, also in AD, the allergens could induce a cutaneous hyper reactivity analogous to the bronchial hyper reactivity (BHR) described in allergic patients with asthma. Nonspecific stimuli can therefore trigger and worsen the skin lesions. Eosinophils, as in asthma, seem to play an important role in inducing and maintaining the skin lesions.Objective: Taken together, these data suggest that in AD there exists a vicious circle, by which immunologic and non immunologic factors act in various ways and at different levels triggering different, though synergistic, reactions to initiate, amplify and maintain the chronic skin lesions characteristic of the condition. Patients and methods:We have prospectively 395 atopic children attending our Division because they were affected with AD, and found 213/395 babies affected contemporaneously with AD and respiratory allergy. The diagnosis of atopic diseases in the children was done according to family and clinical history, physical examination and positive SPTs and/or RAST to the most common inhalant and/or food allergens Results. Of them 14 babies experienced a positive OFC (open challenge test) to different foods (9 cow milk CM , 5 hydrolysate formulas, HFs and one fish, but we stress that three of them reacted to one drop or two ml of CM) Positivity of family history and elevated total IgE confirm that AD is a genetic disease. Conclusion:The data confirms the studies that have suggested that allergens in turn could elicit respiratory symptoms that can be distinguished as food induced asthma and asthma with food allergy (FA). In summary, FA provokes wheezing in a small, but significant number of children suffering from AD and asthma, thus confronting pediatricians with one of the most demanding challenges

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Section: Advances In Biotechnology and Microbiologymentioning

confidence: 99%

Section: Advances In Biotechnology and Microbiologymentioning

confidence: 99%

Respiratory Manifestations of Food Allergy in Babies with Atopic Dermatitis: A Prospective Study in 395 Children

Cantani¹

2016

AIBM

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Atopic Dermatitis

Friedmann¹,

Holden²

2004

Rook's Textbook of Dermatology

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Atopic Eczema (Atopic Dermatitis)

Ardern‐Jones

2016

Rook's Textbook of Dermatology, Ninth Edition

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Atopic eczema is a chronic, relapsing, inflammatory skin condition characterized by itch which affects 20–30% of schoolchildren and 5–10% of adults in the UK. The increased prevalence in both western industrialized countries and developing nations over the last 20 years highlights the strong role of environmental factors in mediating the disease. However, the identification of a strong association between atopic eczema and mutations in the gene encoding filaggrin in 2006 has provided a paradigm shift in our understanding of the role of genetics in this condition and the importance of the function of the epidermal barrier. Indeed, interventions to repair the epidermal barrier show promise in both the treatment and prevention of atopic eczema and its complications. T‐helper 2 cells are central to mediating atopic eczema inflammation and specific targeted interventions are progressing well in clinical trials. Further developments in our understanding of disease pathogenesis, including the role of thymic stromal lymphopoeitin, and recently discovered subsets of immunocytes, are exciting targets and provide an optimistic future for the management of this challenging disease. However, topical therapy with emollients, corticosteroids and calcineurin inhibitors remains the mainstay of treatment. Thus, for more severe disease, current therapeutic options remain limited. As a result, atopic eczema still contributes a significant quality of life and financial burden on society and health care systems worldwide.

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Prognostic factors in atopic dermatitis

Cited by 63 publications

References 6 publications

Respiratory Manifestations of Food Allergy in Babies with Atopic Dermatitis: A Prospective Study in 395 Children

Respiratory Manifestations of Food Allergy in Babies with Atopic Dermatitis: A Prospective Study in 395 Children

Atopic Dermatitis

Atopic Eczema (Atopic Dermatitis)

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