Prognostic Factors in Completely Resected Node-Negative Lung Adenocarcinoma of 3 cm or Smaller

Hung, Jan Jong; Yeh, Yi Chen; Wu, Yu Chung; Chou, Teh Ying; Hsu, Wen Hu

doi:10.1016/j.jtho.2017.07.009

Cited by 28 publications

(18 citation statements)

References 32 publications

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“…Their study showed that patients with the micropapillary and/or solid predominant patterns had signifi cantly higher risk for recurrence. This study also suggested that these patients could benefi t from adjuvant therapy [46]. In completely resected lung adenocarcinoma cases of less than 3 cm, micropapillary pattern was a signifi cant predictor of occult N2 lymph node metastasis in a study including 471 patients performed by Hung et al [47].…”

Section: Pro Gnostic Factors By Tumor Sizementioning

confidence: 59%

Micropapillary Adenocarcinoma of the lung: Recent updates and literature review

Monroig-Bosque¹,

Shehabeldin²,

Ro³

2019

Arch Pulmonol Respir Care

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Background: Lung cancer is the most frequent cause of cancer-related death worldwide. For adenocarcinomas, histological subtyping is typically performed (e.g. lepidic, acinar, papillary, micropapillary, and solid), as suggested by the World Health Organization. Among these, micropapillary carcinoma has been a focus of signifi cant research in recent years, as it is the newest subtype and has the worst prognosis. Herein, we summarize the most relevant fi ndings of this morphological variant in detail with anecdotal experience and a review of the published literature. Results:A PubMed query for "adenocarcinoma of the lung" resulted in 177 full-length articles. The reviewed articles were grouped by category as follows: 1) history (2002)(2003)(2004)(2005)(2006)(2007)(2008), 2) morphologic/ diagnostic features, 3) prognostic implications, 4) molecular features and targeted therapies, and 5) radiologic/imaging fi ndings. Our results consistently showed that a micropapillary carcinoma component is associated with poor prognosis in patients with lung adenocarcinoma. Additionally, our investigation highlighted the fact that there have been no studies validating the diagnostic/morphologic criteria that should be used to achieve an accurate diagnosis of micropapillary lung adenocarcinoma. Nonetheless, we present that molecular studies continue to emerge, and there is signifi cant opportunity for targeted therapeutic options that remains to be explored in depth. Conclusion:Our review offers insight into novel studies focused on micropapillary lung adenocarcinoma. We present the potential for new research opportunities, particularly molecular studies aimed at determining targeted treatment options.

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Section: Pro Gnostic Factors By Tumor Sizementioning

confidence: 59%

Micropapillary Adenocarcinoma of the lung: Recent updates and literature review

Monroig-Bosque¹,

Shehabeldin²,

Ro³

2019

Arch Pulmonol Respir Care

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“…Previous studies on the postoperative prognosis of early stage lung adenocarcinoma mainly focused on stage I or IB. Hung et al [14] reported the prognosis predictive value of micropapillary/solid patterns in lung adenocarcinoma with tumor diameter ≤ 3 cm and lymph node negative. However, the study also included visceral pleural invasion, which is a known risk factor for poor prognosis in stage I lung adenocarcinoma [15] .…”

Section: Discussionmentioning

confidence: 99%

Analysis of prognostic factors after Surgery for Stage IA Invasive Lung Adenocarcinoma

Chen¹,

Ding²,

You³

et al. 2020

Preprint

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Background Lung cancer is one of the most common malignant tumors with poor prognosis. Even for stage IA, many cases relapsed after completed resection. In the era of precision medicine, it is of great significance to determine the risk factors for postoperative recurrence or death in stage IA invasive lung adenocarcinoma. Methods The data of patients with pathological stage IA invasive lung adenocarcinoma underwent complete resection from June 2012 to December 2016 in Fujian Provincial Hospital were collected and retrospectively analyzed. Recurrence-free survival (RFS) was estimated by the Kaplan-Meier method and compared with the log-rank test. The Cox proportional risk model was used to analyze the factors affecting the RFS. Results A total of 210 patients were enrolled in the study. During the follow-up period, 14 (6.7%) patients recurred. Univariate survival analysis showed that predominant pathological subtype, micropapillary/solid pattern, stage T1b and lymphovascular invasion were correlated with RFS (P < 0.05). Cox multivariate analysis showed that the micropapillary/solid pattern was associated with RFS (P < 0.01). Patients with micropapillary/solid pattern had a worse 5-year RFS rate than those without micropapillary/solid pattern (82.3% versus 96.7%, P < 0.001). Conclusion Pathological subtype is a prognostic factor for patients with pathological stage IA invasive lung adenocarcinoma. Patients with micropapillary/solid pattern have a poor prognosis. Lymphovascular invasion and stage T1b are also correlated with poor RFS. These findings may serve as reliable predictive factors for long-term prognostic, and provide theory evidence for the choice of postoperative adjuvant therapy for patients with lung adenocarcinoma in stage IA.

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“…Independent prognostic histopathologic factors have been published and include tumor size, 1 visceral pleural invasion, 2 lymphovascular invasion, 3 large cell neuroendocrine phenotype, 4 and micropapillary adenocarcinoma subtype. 5 Some investigators have moved to tumor molecular profiling and validated gene expression assays to risk stratify patients. 6 Others have assessed the predictive role of common driver mutations in resected early stage NSCLC.…”

Section: Michael Lanuti MDmentioning

confidence: 99%