Prognostic factors in differentiated carcinoma of the thyroid gland

Shah, Jatin P.; Loree, Thom R.; Dharker, Digpal; Strong, Elliót W.; Begg, Colin B.; Vlamis, Vaia

doi:10.1016/s0002-9610(05)80729-9

Cited by 375 publications

(243 citation statements)

References 8 publications

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“…Our results are in agreement with other large studies. (2,3,4,9,13) Female gender, histology and differentiation have been stated as important prognostic factors in some studies (9), however this was not seen in our study. Noguchi et al, did not find histology or differentiation as important prognostic factors on multivariate analysis.…”

Section: Prognosticators Of Survival In Differentiated Thyroid Carcincontrasting

confidence: 60%

Prognosticators of survival in differentiated thyroid carcinoma

Parikh

Rao

Shrikhande

et al. 2001

Indian J Otolaryngol Head Neck Surg

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Section: Prognosticators Of Survival In Differentiated Thyroid Carcincontrasting

confidence: 60%

Prognosticators of survival in differentiated thyroid carcinoma

Parikh

Rao

Shrikhande

et al. 2001

Indian J Otolaryngol Head Neck Surg

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“…The size of the tumor and the presence of distant metastases were strongly linked with the recurrence of tumor in the current study. These tumor characteristics have been confirmed to be related to unfavorable outcome in several reports (12,14,21). The pTNM staging system is considered to be a useful system for discriminating the high and low risk patients.…”

Section: Discussionmentioning

confidence: 78%

“…The mean age of our patients was closer to that of patients studied by Matsubayashi et al (19), but we could not show any significant difference between TILs and tumor recurrence. Several studies (14,15,21) have shown that an unfavorable outcome is associated with age. We found that age over 60 years was related to a higher risk of tumor recurrence and cause-specific mortality, confirming previous findings (14,17).…”

Section: Discussionmentioning

confidence: 99%

Non-suppressed thyrotropin and elevated thyroglobulin are independent predictors of recurrence in differentiated thyroid carcinoma

et al. 1999

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Objective: Although in most cases differentiated thyroid carcinoma (DTC) responds to surgery and radioiodine (RaI) therapy, some patients will have recurrence and eventually cancer-related death. However, although various prognostic factors of DTC have been identified (e.g. staging, suppressed thyrotropin), none of the previous studies have assessed simultaneously their role in multivariate analysis. Design and Methods:In this retrospective population-based study, we reviewed the clinicopathological data of 254 DTC patients treated in eastern Finland during the years 1976-1995, for clinical characteristics, primary treatment, follow-up and cancer recurrence. Tumor stage was based on pathological tumor-node-metastasis (pTNM) classification, and histopathological specimens were reevaluated. Results: DTC recurrence occurred in 33 patients (13%). In univariate analyses, the predictors of recurrence were older age (>60 years, P < 0.05), follicular tumor type (P < 0.01), pTNM classification system (P < 0.05) and post-ablative radioiodine uptake outside the neck (P < 0.05). Non-suppressed serum thyrotropin (TSH) and elevated serum thyroglobulin (>3 mg/l) measured one year after operation were both related to tumor recurrence (P < 0.05 and P < 0.001 respectively). In multivariate analysis the independent predictors for recurrence were both elevated thyroglobulin (P < 0.001) and non-suppressed TSH (P < 0.05) independent of histology, pTNM stage and RaI uptake. Adjusted risk ratio for recurrence of DTC for unsuppressed thyrotropin was 2.3, for elevated thyroglobulin 14.0 and, if both conditions were present, the risk ratio increased to 45.1. Conclusion: Our results suggest that both non-suppressed serum TSH and elevated serum thyroglobulin are related to an increased risk of DTC recurrence independent of tumor type and pTNM stage.

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“…[1][2][3] Although regional lymph node involvement was thought to increase recurrence rate but not affect survival, 4,5 a large population-based study showed an association between lymph node metastasis and increased mortality rate. 6 Central neck dissection (CND) may prevent central neck recurrence, but bilateral CND is associated with significant morbidity, especially postoperative hypoparathyroidism.…”

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confidence: 99%