Prognostic Factors in Gastric Cancer With Serosal Invasion

Baba, Hideo; Korenaga, Daisuke; Okamura, Tomonori; Saito, Atsushi; Sugimachi, Keizō

doi:10.1001/archsurg.1989.01410090071015

Cited by 88 publications

(40 citation statements)

References 15 publications

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“…This may be the reason for the only slightly lower survival rate in the serous invasionpositive groups in our study. In general, the prognosis is considered to be better for well differentiated carcinoma than for undifferentiated carcinoma, but some studies have suggested no difference in prognosis between the two types [1,6,7]. In this study, no difference in survival was observed between the differentiated and undifferentiated types.…”

Section: Discussioncontrasting

confidence: 53%

“…Studies at other institutions have shown poorer prognosis with increasing degree of vessel invasion [1,2,[9][10][11][12]. Another study reported differences in prognosis only according to lymphatic invasion [7]. In the present study, the prognosis was significantly poorer in the marked venous invasion group (v2,3) and in the marked lymphatic invasion group (ly2,3) than in the slight invasion group.…”

Section: Discussionsupporting

confidence: 39%

“…It is difficult to predict survival in all patients with gastric cancer based on only one prognostic factor. Therefore, the prognostic weights of various factors have been studied [1,2,4,[6][7][8][9][10][11][12]. Recent studies of prognosis by multivariate analysis have often used Cox's multivariate analysis type life table model.…”

Section: Discussionmentioning

confidence: 99%

“…Maruyama [4] performed Cox's multivariate analysis and observed the highest risk ratio for depth of invasion, followed, in descending order, by lymph node metastasis, macroscopic type, location, and histological type; he identified these factors as prognostic factors. His study, as well as most other studies, performed analysis in patients with gastric cancer in all stages [1,2,6,7,[9][10][11][12]. Studies involving all patients who underwent gastrectomy as subjects have suggested hematogenous metastasis and peritoneal metastasis as important prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic factors in stage IV gastric cancer: univariate and multivariate analyses

2000

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionsupporting

confidence: 39%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prognostic factors in stage IV gastric cancer: univariate and multivariate analyses

2000

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“…However, recurrences are likely to take on a variety of forms and in different organs, even after curative resection of a gastric cancer (Baba et al, 1989;Ichiyoshi et al, 1990;Moriguchi et al, 1992a). Recurrences were noted at each level of depth of tumour invasion and the rate of recurrences was increased in proportion to the degree of depth of invasion (Moriguchi et al, 1992b).…”

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confidence: 99%

Recurrences and related characteristics of gastric cancer

Maehara

Emi²,

Baba³

et al. 1996

Br J Cancer

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Summary We analysed data on 1117 patients with gastric cancer who were treated by curative resection.Attention was focused on invasion and a recurrence of the cancer. Based on a univariate analysis, death following a recurrence and prognosis were related to age of the patients, size of the tumour, tumour location, tumour tissue differentiation, growth pattern, depth of invasion, lymphatic and vascular invasion and lymph node metastasis. In proportion to the growth potential, determined by the level of proliferating cell nuclear antigen (PCNA) labelling, the death related to a recurrence was increased and the prognosis was poorer. Multivariate analysis showed that the three factors of serosal invasion, PCNA labelling index and lymph node dissection were independent prognostic factors. When sites of recurrence were analysed regarding each depth of invasion, haematogenous recurrence, in particular in the liver, occurred even in cases of an early invasion and many types of recurrences, including peritoneal recurrence, were noted in patients with an advanced state of invasion.

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Lymphadenectomy in Gastric Carcinoma

Jaehne

Meyer²,

Maschek³

et al. 1992

Arch Surg

121

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In 193 gastric resections for adenocarcinoma, lymphadenectomy was prospectively evaluated to quantify the number of lymph nodes and to identify prognostic factors. Overall, 7112 nodes (median, 36.8 per patient) were resected with 27.2% showing metastases. Most nodes were found in the perigastric region. The histologic type and site of the tumor did not influence the number of invaded nodes, but tumor stage and quality of the resection (curative/palliative) did. By multivariate analysis the tumor stage, curative vs palliative resections, and the number of metastatic lymph nodes in curative resections were independent prognostic factors. Patients with less than six metastatic nodes showed a survival not significantly different from that of patients with normal nodes. These patients may be well treated by surgery alone, but the other patients may require multimodal therapy to improve their prognosis.

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Prognostic Factors in Gastric Cancer With Serosal Invasion

Cited by 88 publications

References 15 publications

Prognostic factors in stage IV gastric cancer: univariate and multivariate analyses

Prognostic factors in stage IV gastric cancer: univariate and multivariate analyses

Recurrences and related characteristics of gastric cancer

Lymphadenectomy in Gastric Carcinoma

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