Prognostic factors in head and neck soft tissue sarcomas

Abstract

Tumor size greater than 5 cm and high grade tumors were important prognostic factors for survival. Every effort should be made for early diagnosis and wide surgical excision. For localized recurrent tumors without evidence of distant metastasis, surgery should be attempted whenever possible. High rates of locoregional failure in head and neck area indicate the need for improved treatment strategies.

A review of adult head and neck soft tissue sarcoma in a tertiary centre: malaysia experience

“…The clinical manifestations of soft tissue sarcomas depend of the affected site, tumor size and invasion/compression of adjacent tissues and organs. The metastasis of sarcomas affects lymph nodes in 3-10% and other distant tissues in 28%, being the most affected the lung, followed by bone, the central nervous system and liver [10][11][12][13][14] . The cause of most sarcomas remains unknown, but there are genetic and environmental factors that are clearly associated with these neoplasms.…”

“…, followed by the neck/parotid with 26-53% 13 and paranasal sinuses/ nasal cavity with 5-26% 17 . In our series the most frequent site is the paranasal sinuses (57%) followed by the soft tissues of the neck (14%),the larynx (14%) and the pharynx (14%).…”

“…Today, most sarcomas can be diagnosed with precision using immunohistochemical, cytogenetics, molecular and electron microscopy technique that can detect a specific cell differentiation so histiofibrosarcoma and fibrosarcoma are now a diagnosis by exclusion. In most series the most prevalent subtype is histiofibrosarcoma of 20-34% [10][11][12][13][14] followed by fibrosarcoma 19,20 of 17-38% and angiosarcoma 21 of 19-22%. In our series, the most common subtype is fibrosarcoma (23%), followed by fibromyxoid sarcoma (23%), rhabdomyosarcoma (15%), histofibrosarcoma (15%) synovial sarcoma (8%),hemangiopericytoma (8%) and spindle cell sarcoma (8%).…”

Maxillary Sinus Sarcomas: Epidemiological and Clinicopathological Experience of 25 Years in a National Reference Cancer Center

“…They show a wide spectrum of clinical behavioral ranging from slow growing lesions to aggressive lesions with recurrent and metastatic capacity, which affect lymph nodes in 3-10% and distant sites in 28%, being the most affected site the lung, followed by bone, central nervous system and liver [14][15][16][17][18][19][20][21][22]. In the maxillary sinus three are not large series about this and experience is low and based on isolated case reports and by application of the knowledge derived from the soft tissues of the extremities.…”

“…In the maxillary sinus three are not large series about this and experience is low and based on isolated case reports and by application of the knowledge derived from the soft tissues of the extremities. Then the discussion we will make it based on the studies published to date of head and neck sarcomas in general [11][12][13][14][15][16][17][18][19][20][21][22]. Analysis of the sarcomas in this location poses specific problems.…”