Prognostic factors in non-Hodgkin lymphomas

Cecyn, Karin Zattar; Oliveira, José Salvador Rodrigues de; Alves, Antonio C.; Silva, Maria Regina Regis; Kerbauy, J

doi:10.1590/s1516-31802000000100003

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…When patients were evaluated as over 60 and under 60 years old in two groups, it was found that older age in patients with NHL has an unfavourable impact on OS but had no effect on OS in patients with HL. No statistically significant effect of gender on prognosis and overall survival in lymphoma was reported in previous studies (9,11,4,18). In our study, as consistent with the relevant literature, no significant correlation was found between gender and mortality and OS in patients with HL and in patients with NHL.…”

Section: Discussionsupporting

confidence: 91%

“…In our study, no significant correlation was found between the NLR and mortality and OS in patients with HL and in patients with NHL. A relation between a high LDH level and worse outcome for lymphoma has very often been demonstrated (8,4,13,18,24). No significant correlation was found between the LDH level and mortality and OS in patients with HL and in patients with NHL in our study.…”

Section: Discussioncontrasting

confidence: 71%

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Lenfoma Hastalarin

Medetalibeyoğlu¹,

Ateş²,

Altınkaynak³

et al. 2021

J Istanb Fac Med

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Sistemik inflamasyon göstergesi olan nötrofil-lenfosit oranı (NLR), kanser hastalarında son zamanlarda önerilen basit ve ucuz bir prognostik faktördür. Çalışmamızda, tedavi öncesi yüksek NLR değerinin lenfoma hastalarında kötü sağkalımı gösterdiği hipotezine dayanarak lenfoma hastalarında tedavi öncesi NLR değerlerinin geriye dönük prognostik anlamını inceledik. Gereç ve Yöntem: Çalışmamıza Ocak 2011 ve Aralık 2017 tarihleri arasında İstanbul Tıp Fakültesi iç hastalıkları ve geriatri bölümünde tanı konulan, takip ve tedavi edilmiş 18 yaş üstü lenfoma tanılı hastalar dahil edildi. Sekseniki hastanın verileri retrospektif olarak hastane otomasyon sistemlerinden elde edildi. NLR ve temel karakteristikleri laboratuar parametreleri, prognoz ve sağkalım sonuçları arasındaki ilişki değerlendirildi. Bulgular: HL hastalarında, tanı anında daha ileri yaş grubundaki hastalarda yüksek mortalite hızı ve plevral efüzyonun varlığı uzun dönem sağkalım üzerine anlamlı negatif etkiye sahipti (p=0,008, p=0,035). NHL hastalarında, ileri yaş yüksek IPI skoru, düşük PLT seviyesi ve yüksek beta 2 mikroglobulin düzeyi yüksek mortalite oranıyla ilişkili bulundu (p=0,001, p=0,044, p=0,023, p=0,009). Sonuç: HL ve NHL hastalarında NLR ile mortalite ve uzun dönem sağkalım arasında bir ilişki gösterilememiştir. Bu retrospektif analizin küçük bir örneklem büyüklüğüne sahip olması, geç tanı konulmuş hasta popülasyonu ve tek merkezli bir çalışma olması bu beklenmedik sonucun nedeni olabilir.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 71%

Lenfoma Hastalarin

Medetalibeyoğlu¹,

Ateş²,

Altınkaynak³

et al. 2021

J Istanb Fac Med

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“…Indeed, blacks have a higher risk than whites [48,49], which is coherent with the ndings of our study. However, only a few reports of the association between yellows and disease are available in the literature [50,51]. The effect of the level of yellows on the survival of LGGs was similar according to survival models.…”

Section: According To Our Nomograms Age At Diagnosis Was Con Rmed Asmentioning

confidence: 85%

Nomograms individually predict the overall survival and cancer-specific survival of adult patients with hemispheres lower-grade gliomas: A SEER-Based Study

Che

Lyu

et al. 2021

Preprint

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(1) Background: The 2016 WHO classification of Tumors of the Central Nervous System brought an escalating research interest in lower-grade gliomas (LGGs). This study aims to establish individualized prognostic nomograms to predict the overall survival (OS) and cancer-specific survival (CSS) of patients with LGGs;(2) Methods: We searched the Surveillance, Epidemiology, and End Results (SEER) database for adult patients diagnosed with LGGs from 1998 to 2016. The patient data set selected from SEER was randomly divided into training and validation data sets at a ratio of 7:3. The significant prognostic factors were identified by using multivariate regression models in the training dataset. Then OS and CSS nomograms were developed and internally validated;(3) Results: After the inclusion and exclusion criteria set, a total of 12,630 patients were enrolled in our research. The prognosticators for OS contained age, sex, race, marital status, surgery, radiotherapy, chemotherapy, tumor size/site, laterality, WHO grade, while only chemotherapy among the 11 indicators mentioned above was not related to CSS. The c-indexes of OS and CSS of the validation cohort were 0.749 and 0.761, respectively. The calibration curve plots showed that the predicted probability of 3-, 5-, and 8-years survival rates corresponded well with the actual observed OS and CSS rates;(4) Conclusion: The present study using the SEER database constructed and internally validated prognostic nomograms to predict the OS and CSS of patients with LGGs. The nomograms showed perfect predictive abilities and may be useful clinical tools for decision aids and better supporting patient counselling.

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“…interstitial, focal and diffuse can be seen either alone or in combination. 6 , 7 Patients at high risk for failure with conventional therapy may benefit from investigational approaches. The biological markers of NHL are distinguished in three categories: serological, immunophenotypic and molecular markers.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Patterns of Bone Marrow Infiltration and Biochemical factors in Non-Hodgkin Lymphoma

Mazher¹,

Ahmad²,

Iqbal³

2017

Pak J Med Sci

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Objectives:To investigate the patterns of bone marrow involvement in in Non-Hodgkin’s Lymphoma (NHL) patients and to correlate the patterns with β2 microglobulin (β2m) and lactate dehydrogenase 2 (LD2) levels in these patients.Methods:It was a cross sectional study which was conducted in two years at Post Graduate Medical Institute, Lahore and at Centre of Excellence in Molecular Biology (CEMB), Lahore. The study was conducted on 50 subjects irrespective of age and sex divided into two groups i.e. Group-A comprising 20 normal healthy controls while Group-B consisted of 30 patients of NHL with bone marrow infiltration. Bilateral bone marrow trephine biopsy was done to assess the patterns of bone marrow infiltration. Serum β2m and LD2 isoenzyme levels were determined in already diagnosed 30 patients of NHL. The values were compared with 20 healthy age and sex matched controls. Correlation coefficients were determined using Pearson’s Correlation Coefficient. The estimations were made prior to the institution of chemotherapy.Results:β2m and LD2 levels were significantly (p-Value < 0.05) raised in NHL patients with disease advancement and were compared with controls. These serological markers showed negative correlation (-0.235 for β2m and -0.133 for LD2) with the spread of disease and patterns of involvement in NHL patients.Conclusion:By observing the patterns of bone marrow involvement in NHL patients possible guidelines about prognosis and treatment protocols can be obtained as the serological markers levels correlate well with the spread of disease and patterns of involvement in NHL patients.

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Prognostic factors in non-Hodgkin lymphomas

Abstract: The intermediate grade lymphomas were more compatible with data found in the literature, probably because of the larger number of patients. In this specific case, the treatment did not have an influence on the survival.

Cited by 5 publications

References 21 publications

Lenfoma Hastalarin

Lenfoma Hastalarin

Nomograms individually predict the overall survival and cancer-specific survival of adult patients with hemispheres lower-grade gliomas: A SEER-Based Study

Correlation of Patterns of Bone Marrow Infiltration and Biochemical factors in Non-Hodgkin Lymphoma

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