2022
DOI: 10.1183/13993003.01336-2022
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Prognostic factors in nonsmall cell lung cancer: insights from the German CRISP registry

Abstract: IntroductionUnderstanding prognosis – especially long-term outcome – in advanced non-small-cell lung cancer(NSCLC) is crucial to inform patients, guide treatment and plan supportive and palliative care.MethodsPrognostic factors influencing overall (OS) and progression-free survival (PFS) in 2082 patients with Wild-type(WT)-NSCLC (629 M1a, 249 M1b, 1204 M1c) are reported. Patients were included in the prospective German CRISP-registry recruiting in over 150 centers. Analysis for pretherapeutic factors was based… Show more

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Cited by 13 publications
(13 citation statements)
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“…In terms of the overall survival rate of NSCLC, a recent report indicates that an increased number of involved metastatic organ systems and liver metastases are associated with poor prognosis and reduced survival rate 4 . Specifically, they further suggest that advanced NSCLC has a worse survival chance once liver metastases or greater than four metastatic sites are present 4 .…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…In terms of the overall survival rate of NSCLC, a recent report indicates that an increased number of involved metastatic organ systems and liver metastases are associated with poor prognosis and reduced survival rate 4 . Specifically, they further suggest that advanced NSCLC has a worse survival chance once liver metastases or greater than four metastatic sites are present 4 .…”
Section: Discussionmentioning
confidence: 99%
“…In terms of the overall survival rate of NSCLC, a recent report indicates that an increased number of involved metastatic organ systems and liver metastases are associated with poor prognosis and reduced survival rate 4 . Specifically, they further suggest that advanced NSCLC has a worse survival chance once liver metastases or greater than four metastatic sites are present 4 . In patients with metastatic NSCLC under PD-1 inhibitors treatment, serum lactate dehydrogenase and C-reactive protein concentrations were significantly associated with overall survival 32 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Bei 53 % der Fälle liegt zum Zeitpunkt der Erstdiagnose bereits ein Stadium der Metastasierung vor. Zum Zeitpunkt der Erstdiagnose finden sich bei Patienten mit nicht-kleinzelligem Lungenkarzinom (NSCLC; 85 % der Patienten) im Stadium der Metastasierung bereits bei 32-35 % der Patienten zerebrale Metastasen [1]. Das zentrale Nervensystem stellt nach den Knochen das zweithäufigste Kompartiment einer Filialisierung außerhalb der Lunge dar [1].…”
Section: Introductionunclassified
“…Zum Zeitpunkt der Erstdiagnose finden sich bei Patienten mit nicht-kleinzelligem Lungenkarzinom (NSCLC; 85 % der Patienten) im Stadium der Metastasierung bereits bei 32-35 % der Patienten zerebrale Metastasen [1]. Das zentrale Nervensystem stellt nach den Knochen das zweithäufigste Kompartiment einer Filialisierung außerhalb der Lunge dar [1]. Bei 15 % der Neudiagnosen liegt ein kleinzelliges Lungenkarzinom vor, welches in 71 % der Fälle im Stadium der Metastasierung diagnostiziert wird.…”
Section: Introductionunclassified