Prognostic factors in pathological stage IB nonsmall cell lung cancer greater than 3 cm

Abstract

Significant heterogenity of stage IB (sixth edition of the TNM staging system) nonsmall cell lung cancer (NSCLC) has been identified, and further subclassification according to tumour size has been proposed. The aim of this study is to evaluate the prognostic factors in patients with resected stage IB NSCLC .3 cm.From January 1980 to December 2000, 525 patients underwent surgical resection for stage IB NSCLC .3 cm at Taipei Veterans General Hospital, Taipei, Taiwan. The clinicopathological characteristics of these patients were retrospectively reviewed.The 5-and 10-yr overall survival rates were 44.9% and 27.3%, respectively. Age (p,0.001), tumour size (p50.002), extent of pulmonary resection (p50.002), histological type (p50.005) and number of mediastinal lymph nodes dissected/sampled (p50.004) were significant predictors for overall survival in multivariate analysis. Patients with tumour size .7 cm, or .5 to f7 cm, had a worse survival than those with tumour size .3 to f5 cm. However, visceral pleural invasion did not influence overall survival.Stage IB NSCLC with a diameter .3 cm may be subclassified according to tumour size regardless of visceral pleural invasion.

Prognostic Significance of the Extent of Visceral Pleural Invasion in Completely Resected Node-Negative Non-small Cell Lung Cancer

“…21,22 To investigate their impact on overall survival and recurrence-free survival, clinicopathologic factors were analyzed in univariate and multivariate analyses. The length of overall survival was defi ned as the interval between the date of surgical resection and the date of either death or the last follow-up.…”

“…The preoperative staging work-up was done as previously described. 21,22 All patients underwent complete resection of lung cancer with mediastinal lymph node dissection/sampling as previously described. 21,22 Histologic typing was determined according to the World Health Organization classifi cation.…”

“…21,22 All patients underwent complete resection of lung cancer with mediastinal lymph node dissection/sampling as previously described. 21,22 Histologic typing was determined according to the World Health Organization classifi cation. 23 Determination of disease stages were based on the TNM classifi cation (seventh edition) of the American Joint Committee on Cancer and the International Union Against Cancer.…”

“…18,19 Determination of VPI was done as previously described. 22 VPI was classifi ed according to the proposal of IASLC. 20 PL1 and PL2 indicate VPI and are a T2 descriptor.…”

Predictors of Death, Local Recurrence, and Distant Metastasis in Completely Resected Pathological Stage-I Non–Small-Cell Lung Cancer

“…19,20 Mediastinoscopy was not a routine preoperative staging procedure, and was performed only when enlarged mediastinal lymph nodes (LNs) (diameter > 1.0 cm) were shown by the computed tomographic scan. 19,20 Mediastinoscopy was not a routine preoperative staging procedure, and was performed only when enlarged mediastinal lymph nodes (LNs) (diameter > 1.0 cm) were shown by the computed tomographic scan.…”