2016
DOI: 10.3803/enm.2016.31.3.424
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Prognostic Factors in Patients Hospitalized with Diabetic Ketoacidosis

Abstract: BackgroundDiabetic ketoacidosis (DKA) is characterized by a biochemical triad of hyperglycemia, acidosis, and ketonemia. This condition is life-threatening despite improvements in diabetic care. The purpose of this study was to evaluate the clinical and biochemical prognostic markers of DKA. We assessed correlations in prognostic markers with DKA-associated morbidity and mortality.MethodsTwo hundred and seventy patients that were hospitalized with DKA over a period of 2 years were evaluated clinically and by l… Show more

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Cited by 47 publications
(46 citation statements)
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“… 10 While inpatient mortality rates for DKA are generally very low (<1% in Scotland 14 and in the USA 15 rates vary substantially based on healthcare setting; a recent analysis conducted in India reported that up to 30% of hospitalised DKA cases result in inpatient death. 13 Among all T1D-related deaths for patients aged less than 30 years, 54%–76% can be attributed to DKA. 16–19 Risk factors associated with a higher frequency of DKA may include younger age at time of DKA hospitalisation, 20 21 higher mean glycosylated haemoglobin A1c (HbA1c), 11 20–23 infection, 24 CSII pump failure, 25 26 lower socioeconomic status/household income, 11 20 22 lower physical activity level 27 and psychiatric symptoms/depression.…”
Section: Introductionmentioning
confidence: 99%
“… 10 While inpatient mortality rates for DKA are generally very low (<1% in Scotland 14 and in the USA 15 rates vary substantially based on healthcare setting; a recent analysis conducted in India reported that up to 30% of hospitalised DKA cases result in inpatient death. 13 Among all T1D-related deaths for patients aged less than 30 years, 54%–76% can be attributed to DKA. 16–19 Risk factors associated with a higher frequency of DKA may include younger age at time of DKA hospitalisation, 20 21 higher mean glycosylated haemoglobin A1c (HbA1c), 11 20–23 infection, 24 CSII pump failure, 25 26 lower socioeconomic status/household income, 11 20 22 lower physical activity level 27 and psychiatric symptoms/depression.…”
Section: Introductionmentioning
confidence: 99%
“…The highest rates of DKA have been suggested to occur in regions least able to afford health care 38 . Mortality might also be higher in these populations; for example, data from India showed a 30% mortality in those presenting with DKA 39 , and studies from sub-Saharan Africa have reported similarly high mortality (26-41.3%), whereas a study from Jamaica reported a mortality of 6.7% [39][40][41] .…”
Section: Epidemiologymentioning
confidence: 99%
“…Electrolyte imbalance was observed in our patient, with severe depletion of phosphates. Severe hypophosphataemia may lead to rhabdomyolysis, and paralysis is an important predictor of the DKA-associated mortality [11]. It is recommended that hypophosphataemia is treated; however, one should be aware that such therapy may contribute to hypocalcaemia.…”
Section: Discussionmentioning
confidence: 99%