Prognostic factors in patients with unresectable pancreatic cancer

Kadokura, Makoto; Ishida, Yasuaki; Tatsumi, Akihisa; Takahashi, Ei; Shindo, Hiroko; Amemiya, Fumitake; Takano, Shinichi; Fukasawa, Mitsuharu; Satô, Tadashi; Enomoto, Nobuyuki

doi:10.2958/suizo.31.631

Journal of the Japan Pancreas Society

2016

DOI: 10.2958/suizo.31.631

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Prognostic factors in patients with unresectable pancreatic cancer

Makoto Kadokura

Yasuaki Ishida

Akihisa Tatsumi

et al.

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Cited by 3 publications

References 25 publications

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Prognosis of pancreatic cancer with Trousseau syndrome: a systematic review of case reports in Japanese literature

Wakabayashi,

Kikuchi,

Yamaguchi

et al. 2023

J Egypt Natl Canc Inst

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Trousseau syndrome is a paraneoplastic syndrome associated with a risk of poor prognosis. We reviewed the survival time and prognosis of patients with Trousseau syndrome. We identified 40 cases from 28 reports of Trousseau syndrome due to pancreatic cancer. We analyzed 20 cases based on reports providing sufficient information on the stage/location of pancreatic cancer and survival time after Trousseau syndrome. The median survival time was 2.0 months. There was no statistical difference between performance status (PS) 0–1 and PS 4, stages I–III and IV, and pancreatic head and body/tail. However, statistically significant differences were noted between the median survival time of patients who continued treatment for pancreatic cancer even after Trousseau syndrome and those who discontinued treatment (P = 0.005). Although only a small number of cases were analyzed in this study, the results indicated that patients with pancreatic cancer who developed Trousseau syndrome had a poor prognosis, and chemotherapy should be continued, if possible.

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Prognosis of pancreatic cancer with Trousseau syndrome: a systematic review of case reports in Japanese literature

Wakabayashi,

Kikuchi,

Yamaguchi

et al. 2023

J Egypt Natl Canc Inst

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Significance of Baseline and Changes of Tumor Markers and Neutrophil-to-Lymphocyte Ratio in Predicting Overall Survival for Patients with Advanced Pancreatic Adenocarcinoma: A Retrospective Analysis

Kadokura

Tanaka

Amemiya

et al. 2023

Journal of Cancer Research and Practice

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Background: The usefulness of various prognostic factors for pancreatic cancer has been reported, but limited studies have focused on these changes during chemotherapy. The purpose of the present study was to investigate the prognostic factors and to evaluate the significance of these changes during chemotherapy in patients with advanced pancreatic cancer (APC). Materials and Methods: We retrospectively analyzed 213 patients with APC who underwent chemotherapy between January 2006 and December 2018 at Kofu Municipal Hospital and University of Yamanashi Hospital. Univariate and multivariate cox regression models were applied to investigate independent prognostic factors. Results: Multivariate analysis revealed that Eastern Cooperative Oncology Group Performance Status 2 (hazard ratio [HR] 4.07, P < 0.01), neutrophil-to-lymphocyte ratio (NLR) ≥3.9 (HR 1.97, P < 0.001), modified Glasgow prognostic score 1–2 (HR 2.77, P < 0.001), carcinoembryonic antigen ≥5.0 (HR 1.44, P = 0.026), carbohydrate antigen 19-9 ≥37 (HR 1.83, P = 0.004), ΔNLR >0 (HR 2.01, P < 0.001), ΔCEA (subtracting the baseline from the start of second cycles of chemotherapy) >0 (HR 1.64, P = 0.002), and ΔCA19-9>0 (HR 1.77, P = 0.002) were independent negative prognostic factors. Conclusion: Baseline and change in tumor markers and NLR are useful in predicting overall survival in APC patients undergoing chemotherapy.

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Usefulness of Nutrition, Immunity, and Inflammation Indices as Criteria for Chemotherapy Discontinuation in Patients with Relapsed and Unresectable Pancreatic Cancer

Nakai,

Kikkawa,

Funahara

et al. 2021

Jpn. J. Pharm. Health Care Sci.

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Prognostic factors in patients with unresectable pancreatic cancer

Cited by 3 publications

References 25 publications

Prognosis of pancreatic cancer with Trousseau syndrome: a systematic review of case reports in Japanese literature

Prognosis of pancreatic cancer with Trousseau syndrome: a systematic review of case reports in Japanese literature

Significance of Baseline and Changes of Tumor Markers and Neutrophil-to-Lymphocyte Ratio in Predicting Overall Survival for Patients with Advanced Pancreatic Adenocarcinoma: A Retrospective Analysis

Usefulness of Nutrition, Immunity, and Inflammation Indices as Criteria for Chemotherapy Discontinuation in Patients with Relapsed and Unresectable Pancreatic Cancer

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