Prognostic factors in patients with jaw sarcomas

Abstract

The aim of this study was to identify the prognostic factors related to the survival of patients with sarcomas of the jaw treated in the Dr. Eduardo Caceres Graziani National Institute for Neoplastic Diseases, Lima, Peru. Age, gender, delay in consultation, diagnostic delay, therapeutic delay, tumor size, tumor location, facial asymmetry, pain, treatment type, and histopathological diagnosis were all evaluated as possible prognostic factors that would influence survival in those with jaw sarcomas. In the analysis, the following was used: mortality tables, KaplanMeier's product-limit method, log-rank, and Breslow and Tarone-Ware tests; for the prognostic factors, Cox's Regression Model was used. The overall survival rate, with the patient being free from disease at two years, was 55%, and that at five years was 45%. In the independent analysis of the prognostic factors, four variables were statistically significant in influencing survival: gender (p = 0.043), histopathologic diagnosis (p = 0.019), tumor location (p = 0.019), and treatment type (p = 0.030). According to Cox's Regression Model for the multivariate analysis, statistically significant prognostic factors were: gender (p = 0.086), tumor location (p = 0.020), and treatment type (p = 0.092). Thus, the variables of gender, tumor location, and treatment type were determined to be predictive factors for prognosis of survival.

Osteosarcoma of the jaw: an analysis of a series of 74 cases

“…In the present series, radical surgery was the treatment of choice, and the survival rate at 5 years for the 17 patients with available follow-up was 68%. In agreement with Morales Vadillo et al 17 who studied a series of cases of sarcoma of the head and neck, which included cases of osteosarcoma of the jaw, our results showed lower survival in women.…”

“…To date, there is no clear and precise information on the clinical-histopathological features and clinical course of osteosarcoma of the jaw, and there are few reports of series that have included a significant number of patients with this disease. [3][4][5][6][14][15][16][17][18][19] To our knowledge, this is the first study to report data on the frequency of osteosarcoma of the jaw with respect to aggressive and/or malignant pathol-ogy affecting the jaw bones. In the present series of cases, osteosarcoma of the jaw accounted for 10% of primary malignant and aggressive tumours of the jaw bones (after ameloblastoma and myxoma, which are both benign, locally aggressive odontogenic tumours), and for 8% of all malignant lesions, including metastatic and lymphoproliferative tumours.…”

“…The series of cases of osteosarcoma of the jaw reported in the literature are not large, and their results are difficult to generalize. [3][4][5][6][14][15][16][17][18][19] It is thus relevant to analyse a new series of cases that may contribute further information for the characterization of this entity. A series of 74 cases of osteosarcoma of the jaw were analysed, and the results are presented in this article.…”

Osteosarcoma of the Jaw: Classification, Diagnosis and Treatment

“…Osteosarcoma of the jaw (JOS) is extremely rare, representing about 7% of all osteosarcomas and 1% of all head and neck malignancies [1,2,[5][6][7][8][9].…”

“…Surgery has a crucial role as the ability to treat a patient rest on a combination of aggressive surgical resection and advanced reconstructive techniques. The single most important factor for deinite cure is radical resection [5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] with particular atention to achieve clear margins, a diicult task in relation to the complex anatomy of the maxillofacial region [13,14,[20][21][22][23].…”