Prognostic factors in sinonasal sarcomas: Analysis of the surveillance, epidemiology and end result database

Abstract

This study comprises the largest analysis of patients with sinonasal sarcoma in the literature and demonstrates the impact of patient age, tumor histology, and tumor location on the overall survival of individuals with these rare malignancies.

Sinonasal fibrosarcoma: analysis of the Surveillance, Epidemiology, and End Results database

“…13 SNFS patients had a mean survival of 119.7 months and 5-year DSS rate of 77.8% in our study. Previous analysis had demonstrated that fibrosarcoma had a more grave overall 5-year survival at 23%; however, this survival rate may have been affected by a small sample size (16 cases).…”

“…Previous analysis had demonstrated that fibrosarcoma had a more grave overall 5-year survival at 23%; however, this survival rate may have been affected by a small sample size (16 cases). 4 A SEER study by Wu et al 13 showed an overall 5-year survival rate of 56.6% for "miscellaneous fibrous malignancies." It is possible that SNFS carried a better prognosis compared to other fibrous malignancies analyzed in their study, resulting in a lower survival rate compared to the present study.…”

“…Because of the rare nature of this tumor, there exists a paucity of literature evaluating its clinical characteristics. A study by Wu et al 13 previously utilized the SEER database to analyze all sarcomas of the sinonasal region. However, this study lacked specific analysis on fibrosarcomas.…”

“…12 Here, we present an epidemiologic analysis of SNFS using the U.S. National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database. Although a previous study by Wu et al 13 used the SEER database to analyze all subtype of sarcoma cases in the sinonasal region, no previous study has specifically performed an in-depth analysis of SNFS cases in the database. We analyzed 51 cases of SNFS from 18 SEER registries, representing the largest cohort of SNFS patients studied to date.…”

Novel PAX3-NCOA1 Fusions in Biphenotypic Sinonasal Sarcoma With Focal Rhabdomyoblastic Differentiation

“…1,2 Sinonasal tract sarcomas comprise less than 10% of head and neck sarcomas and tend to be more aggressive due to their proximity to the eyes and brain. 3,4 The histologic classification is an important prognostic factor, with rhabdomyosarcoma (RMS) conferring the most dismal outcome, with 30% survival rate at 5 years. 3,4 Given the rarity and wide morphologic spectrum of sinonasal sarcomas, the histologic diagnosis is often challenging, especially on limited and fragmented biopsies.…”