Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona

Abstract

Background In addition to the lack of COVID-19 diagnostic tests for the whole Spanish population, the current strategy is to identify the disease early to limit contagion in the community. Aim To determine clinical factors of a poor prognosis in patients with COVID-19 infection. Design and setting Descriptive, observational, retrospective study in three primary healthcare centres with an assigned population of 100,000. Method Examination of the medical records of patients with COVID-19 infections confirmed by polymerase chain reaction. Logistic multivariate regression models adjusted for age and sex were constructed to analyse independent predictive factors associated with death, ICU admission and hospitalization. Results We included 322 patients (mean age 56.7 years, 50% female, 115 (35.7%) aged � 65 years): 123 (38.2) were health workers (doctors, nurses, auxiliaries

SARS-CoV-2 infection in patients with primary Sjögren syndrome: characterization and outcomes of 51 patients

“…With respect to the main outcomes of SARS-CoV-2 infection, the figures observed in our patients with primary SS were similar to that reported in patients with rheumatic diseases for hospitalization (44–68%) [ 19 , 20 , 28 ], need for supplemental oxygen (33%) [ 20 ], ICU admission (15–21%) [ 19 , 20 ] and mortality rate (6–9%) [ 19 , 20 , 28 ], and also similar to the figures recently reported in the Spanish general population (hospitalization rate of 49.1% and mortality rate of 5.6%, respectively) [ 32 ]. However, when we stratified the outcomes according to the presence or absence of baseline comorbidities, the figures for poor outcomes were significantly higher in primary SS patients and concomitant comorbidities.…”

“…Previous studies in patients with rheumatic diseases have reported increased odds of hospitalization in patients under corticosteroid therapy, lower odds in those treated with biologics in monotherapy, and no significant association with the use of antimalarials [ 28 ]. According to a recently published study by Sisó-Almirall et al [ 32 ], autoimmune diseases were an independent risk factor for ICU admission and death.…”

Recommendations for use of antigenic tests in the diagnosis of acute SARS-CoV-2 infection in the second pandemic wave: attitude in different clinical settings

“…In addition, with the main objective of detecting new positive cases of COVID-19 in asymptomatic phase, an ADT or a PCR or TMA will be performed after the identification of the contact. PCR or TMA are preferable in people who may be at higher risk of evolving into serious, critical or fatal disease (Table 3) [35][36][37][38][39][40], their caregivers and partners, and in health workers, or workers in social health centers or essential services. In the rest of the cases ADT may be of choice.…”

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“…Tras la vacunación, la respuesta específica de células de T parece adelantarse al menos una semana respecto a la humoral [34]. La tecnología implementada en las vacunas frente a SARS-CoV-2 es diversa e incluye virus vivos enteros atenuados e inactivados, vectores virológicos (replicativos y no replicativos que expresen un antígeno relevante), partículas similares a virus, péptidos, proteínas recombinantes, células presentadoras de antígeno y ácidos nucleicos (ADN y ARN) [35][36][37]. Las vacunas de ácidos nucleicos constituyen la alternativa de inmunización más novedosa y se sustentan en la transferencia genética para la síntesis endógena de proteínas del virus por las células del receptor sin una estimulación antigénica directa.…”

“…All authors have indicated they have no potential conflicts of interest to disclose. 7 (36,8) 84 (52,8) 91 (50,6) 0,149 Edad (años) 10 (24) 7 (16) 8 (18) 0,061 Pediátricos (≤16)…”